論文

2009年6月

Reduced ability of hemagglutinin of the CAM-70 measles virus vaccine strain to use receptors CD46 and SLAM

VACCINE
  • Seiichi Kato
  • ,
  • Shinji Ohgimoto
  • ,
  • Luna Bhatta Sharma
  • ,
  • Sekiko Kurazono
  • ,
  • Minoru Ayata
  • ,
  • Katsuhiro Komase
  • ,
  • Makoto Takeda
  • ,
  • Kaoru Takeuchi
  • ,
  • Toshiaki Ihara
  • ,
  • Hisashi Ogura

27
29
開始ページ
3838
終了ページ
3848
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.vaccine.2009.04.010
出版者・発行元
ELSEVIER SCI LTD

The CAM-70 measles Virus (MV) vaccine strain is Currently used for vaccination against measles. We examined the fusion-inducing ability of the CAM-70 hemagglutinin (H) protein and found that it was impaired in both CD46- and signaling lymphocyte activation molecule (SLAM)-expressing cells. We also generated recombinant MVs possessing H genes derived from the CAM-70 strain. The CAM-70 H protein impaired viral growth in both CD46- and SLAM-expressing cells. In peripheral blood lymphocytes (PBL) and monocyte-derived dendritic cells (Mo-DC), the CAM-70 strain did not grow efficiently. Infection with recombinant MVs revealed that impaired growth of the CAM-70 strain was attributed to the H gene only partly in PBL and largely in Mo-DC. Thus, impaired fusion-inducing ability of the H protein may be one of the underlying molecular mechanisms resulting in the attenuation of the CAM-70 strain. (C) 2009 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1016/j.vaccine.2009.04.010
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000267581300006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.vaccine.2009.04.010
  • ISSN : 0264-410X
  • Web of Science ID : WOS:000267581300006

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