論文

2007年8月

Humoral immune responses against norovirus infections of children

JOURNAL OF MEDICAL VIROLOGY
  • Nobuhiro Iritani
  • ,
  • Toshiyuki Seto
  • ,
  • Hideji Hattori
  • ,
  • Katsurou Natori
  • ,
  • Naokazu Takeda
  • ,
  • Hideyuki Kubo
  • ,
  • Tsunekazu Yamano
  • ,
  • Minoru Ayata
  • ,
  • Hisashi Ogura
  • ,
  • Yoshiyuki Seto

79
8
開始ページ
1187
終了ページ
1193
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/jmv.20897
出版者・発行元
WILEY-LISS

In 2 infants with gastroenteritis associated with Norovirus (NoV), serum immunoglobulin (Ig) G, IgM, IgA, and fecal IgA antibody responses against NoV were examined by enzyme-linked immunosorbent assay using 11 different antigenic and genetic types of NoV virus-like particles expressed in insect cells. These two cases were putative primary single NoV infections, because antibodies against NoVs were not detected in acute-phase serums. In one of two cases, long-term excretion of virus RNA for 33 days was observed. Serum IgG responses demonstrated strong seroresponse to the homologous type, and weak seroresponse to the heterologous types within the genogroup. After more than 2 years, the IgG antibody titer remained high to the homologous type and low to the heterologous type within the genogroup. IgM and IgA were specific to the homologous type. IgM was short lived and the serum IgA antibody titer remained low to the homologous type for a long period. These results improve our understanding of the humoral immune response to NoV infection.

Web of Science ® 被引用回数 : 20

リンク情報
DOI
https://doi.org/10.1002/jmv.20897
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247642200021&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/jmv.20897
  • ISSN : 0146-6615
  • Web of Science ID : WOS:000247642200021

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