2000年4月
Effect of particles and interface conditions on fibrous tissue interposition between bone and implant. A particle challenge model in rabbit
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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- 巻
- 11
- 号
- 4
- 開始ページ
- 255
- 終了ページ
- 259
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1023/A:1008936830622
- 出版者・発行元
- SPRINGER
Interposed fibrous tissue at bone-implant interfaces was quantitatively measured in the presence or absence of polyethylene (PE) or alumina particles. Three different conditions of the interface were designed by implanting a pre-polymerized polymethylmethacrylate (PMMA) plug (plug group), a doughy PMMA (injection group) and a hydroxyapatite (HA) plug (HA group) in the hole drilled at the intercondylar notch of rabbit knees. PE (170 +/- 18 mu m) or alumina particles (88 +/- 26 mu m) were repeatedly administered into the knee joints at one month intervals (six times). All animals were sacrificed seven months after the implantation. The bone-implant interface was histomorphometrically examined using undecalcified ground sections. In the plug group, the PE particles significantly increased the extent of the interposed fibrous tissue (p < 0.05), while the alumina particles showed no effect. In contrast, both particles showed no significant effects in the injection and the HA groups. These results indicate that both particle characteristics and conditions of the bone-implant interface affected particle-induced fibrous tissue interposition. The loose PMMA plug with PE particles induced the greatest amount of fibrous tissue interposition. (C) 2000 Kluwer Academic Publishers.
- リンク情報
- ID情報
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- DOI : 10.1023/A:1008936830622
- ISSN : 0957-4530
- eISSN : 1573-4838
- Web of Science ID : WOS:000085623900009