Ichiro Nishikata

Profile Information

Degree: 博士（医学）(宮崎大学)

Researcher number: 50253844
J-GLOBAL ID: 200901009225134974
researchmap Member ID: 1000176162

Research Interests

Research Areas

Research History

Apr, 2015 - Present

School of Medical Life Sciences Department of Medical Life Sciences, Kyushu University of Health and Welfare
Apr, 2007 - Mar, 2015

Faculty of Medicine School of Medicine, University of Miyazaki
Oct, 2003 - Mar, 2007

Faculty of Medicine School of Medicine, University of Miyazaki
Apr, 1993 - Sep, 2003

助手, 生化学第一講座, 宮崎医科大学

Papers

Clinical significance of soluble CADM1 as a novel marker for adult T-cell leukemia/lymphoma.

Nakahata S, Syahrul C, Nakatake A, Sakamoto K, Yoshihama M, Nishikata I, Ukai Y, Matsuura T, Kameda T, Shide K …

Haematologica, 105(2) 532-542, Feb 13, 2020 Peer-reviewed
Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB

Sarkar B, Nishikata I, co, Nakahata S, Ichikawa T, Shiraga T, Saha H. R, Fujii M, Tanaka Y, Shimoda K …

Scientific Reports, 9(1) Article number:3491(1)-Article number:3491(14), Mar 5, 2019 Peer-reviewed
Increased plasma caveolin-1 levels are associated with progression of prostate cancer among Japanese men.

Sugie S, Mukai S, Tsukino H, Toda Y, Yamauchi T, Nishikata I, Kuroda Y, Morishita K, Kamoto T

Anticancer Research, 33(5) 1893-1898, May, 2013 Peer-reviewed
Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation.

Nishikata I, Nakahata S, Saito Y, Kaneda K, Ichihara E, Yamakawa N, Morishita K

Oncogene, 30(40) 4194-4207, Oct 6, 2011 Peer-reviewed
Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2

Akiko Shimahara, Norio Yamakawa, Ichiro Nishikata, Kazuhiro Morishita

Journal of Biological Chemistry, 285(22) 16967-16977, May 28, 2010 Peer-reviewed
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

Hiromi Yuasa, Yuichi Oike, Atsushi Iwama, Ichiro Nishikata, Daisuke Sugiyama, Archibald Perkins, Michael L. Mucenski, Toshio Suda, Kazuhiro Morishita

EMBO Journal, 24(11) 1976-1987, Jun 1, 2005 Peer-reviewed
Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia.

Sasaki, H, Nishikata, I, Shiraga, T, Akamatsu, E, Fukami, T, Hidaka T, Kubuki, Y, Okayama, A, Hamada, K, Okabe, H …

Blood, 105(3) 1204-1213, Feb 1, 2005 Peer-reviewed
Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells.

Yoshida, M, Nosaka, K, Yasunaga, J-I, Nishikata, I, Morishita, K, Matsuoka, M

Blood, 103(7) 2753-2760, Apr 1, 2004 Peer-reviewed
A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation.

Nishikata, I, Sasaki, H, Iga, M, Tateno, Y, Imayoshi, S, Asou, N, Nakamura, T, Morishita, M

Blood, 102(9) 3323-3332, Nov 1, 2003 Peer-reviewed
Analysis of hepatitis C virus (HCV) RNA in the lesions of lichen planus in patients with chronic hepatitis C: Detection of anti-genomic- as well as genomic-strand HCV RNAs in lichen planus lesions

Motoki Kurokawa, Tomonori Hidaka, Hidenori Sasaki, Ichiro Nishikata, Kazuhiro Morishita, Mitsuru Setoyama

Journal of Dermatological Science, 32(1) 65-70, 2003 Peer-reviewed
Earlier detection of human immunodeficiency virus type 1 p24 antigen and immunoglobulin G and M antibodies to p17 antigen in seroconversion serum panels by immune complex transfer enzyme immunoassays.

Hashida, S, Ishikawa, S, Hashinaka, K, Nishikata, I, Oka, S, Ishikawa, E

Clinical and Diagnostic Laboratory Immunology, 7(6) 872-881, Nov, 2000 Peer-reviewed
Recombinant p51 as antigen in an immune complex transfer enzyme immunoassay of immunoglobulin G antibody to human immunodeficiency virus type 1

K Hashinaka, S Hashida, Nishikata, I, A Adachi, S Oka, E Ishikawa

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 7(6) 967-976, Nov, 2000 Peer-reviewed
Earlier detection of human immunodeficiency virus type 1 p24 antigen and immunoglobulin G and M antibodies to p17 antigen in seroconversion serum panels by immune complex transfer enzyme immunoassays

S Hashida, S Ishikawa, K Hashinaka, Nishikata, I, S Oka, E Ishikawa

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 7(6) 872-881, Nov, 2000 Peer-reviewed
Immune complex transfer enzyme immunoassay for antibody IgM to HIV-1 p17 antigen

S Hashida, S Ishikawa, Nishikata, I, K Hashinaka, S Oka, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 12(6) 329-336, 1998 Peer-reviewed
Optimal conditions of immune complex transfer enzyme immunoassay for p24 antigen of HIV-1

S Hashida, S Ishikawa, K Hashinaka, Nishikata, I, A Saito, A Takamizawa, H Shinagawa, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 12(2) 115-120, 1998 Peer-reviewed
Optimal conditions of immune complex transfer enzyme immunoassays for antibody IgGs to HIV-1 using recombinant p17, p24, and reverse transcriptase as antigens

S Hashida, S Ishikawa, K Hashinaka, Nishikata, I, S Oka, K Shimada, A Saito, A Takamizawa, H Shinagawa, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 12(2) 98-107, 1998 Peer-reviewed
Immune complex transfer enzyme immunoassay for antibody IgG to HIV-1 gp41 antigen using synthetic peptides as antigens

S Hashida, S Ishikawa, K Hashinaka, Nishikata, I, S Oka, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 12(4) 197-204, 1998 Peer-reviewed
Shortening of the window period in diagnosis of HIV-1 infection by simultaneous detection of p24 antigen and antibody IgG to p17 and reverse transcriptase in serum with ultrasensitive enzyme immunoassay

S Hashida, K Hashinaka, Nishikata, I, S Oka, K Shimada, A Saito, A Takamizawa, H Shinagawa, E Ishikawa

JOURNAL OF VIROLOGICAL METHODS, 62(1) 43-53, Oct, 1996 Peer-reviewed
Earlier diagnosis of HIV-1 infection by simultaneous detection of p24 antigen and antibody IgGs to p17 and reverse transcriptase in serum with enzyme immunoassay

S Hashida, K Hashinaka, Nishikata, I, A Saito, A Takamizawa, H Shinagawa, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 10(4) 213-219, 1996 Peer-reviewed
Ultrasensitive and more specific enzyme immunoassay (immune complex transfer enzyme immunoassay) for p24 antigen of HIV-1 in serum using affinity-purified rabbit anti-p24 Fab' and monoclonal mouse anti-p24 Fab'

S Hashida, K Hashinaka, Nishikata, I, A Saito, A Takamizawa, H Shinagawa, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 10(5) 302-307, 1996 Peer-reviewed

Misc.

白血病化に関係する新規zinc finger protein MEL1の単離と機能解析

第23回日本分子生物学会年会講演要旨集, 341, 2000
Isolation and characterization of a novel zinc finger protein, MEL1, which is associated with leukemogenesis

341, 2000
Preparations of recombinant HIV-1 p66 antigen to improve the specificity of immune complex transfer enzyme immunoassay of antibody IgG to HIV-1 reverse transcriptase

K Hashinaka, Nishikata, I, S Hashida, A Adachi, S Oka, E Ishikawa

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 14(4) 169-179, 2000
体液中の微量のニコチン及びコチニンの定量法開発に関する研究-酵素免疫測定法による検討-

石川栄治, 西片一朗, 橋田誠一

日本喫煙科学財団研究年報, 836-843, Mar, 1994
Development of methods for the detection of nicotine and cotinine at low concentration in body fluids -application of enzyme immunoassay-

Smoking Research Foundation Annual Reserach Report, 866, 1994
Deveropment of PROBLOT HTLV-I for Detection of Anti-HTLV-I Antibody

The Journal of Clinical Laboratory Instruments and Reagents, 16(3) 579-583, Jun, 1993
HTLV-I抗体検出用プロブロットHTLV-Iの開発

臨床検査機器・試薬, 16(3) 579, 1993

Presentations

Down-regulation of p47 induces high expression of CADM1 via the NF -kB pathway in adult T-cell leukemia/lymphoma.

Dec 3, 2019
新規腫瘍マーカー候補としての前立腺がん特異的エクソソームの解析

西片一朗

第57回日本臨床化学会年次学術集会, Oct 8, 2017, 一般社団法人・日本臨床化学会
カベオリン1（CAV1)含有エクソソームは前立腺がんの新規腫瘍マーカー候補である

西片一朗, 大澤幸希光, 西森誠, 宮本朋幸, 薬師寺宏匡, 大野節代, 大野英治

第63回日本臨床検査医学会学術集会, Sep 4, 2016, 一般社団法人・日本臨床検査医学会
Promoteosomal degradation of p47 by HTLV-1 Tax with prpmoter methylation enhannced CADM1 expression in ATL cells

Morishita K, Nishikata I, Nakahata S, Ichikawa T, Fujii M, Iha H, Tanaka Y

The 74th Annual Meeting of the Japanese Cancer Association, Oct 8, 2015, The Japanese Cancer Association
血中CADM1/TSLC1測定によるATL診断法の開発

中武彩子, 小林行治, 中畑新吾, 西片一朗, 岩永正子, 相良康子, 北中明, 天野正宏, 前田宏一, 末岡栄三朗, 瀬戸山充, 岡山昭彦, 宇都宮與, 下田和哉, 渡邉俊樹, 森下和広

第1回HTLV-1学会総会, Aug 24, 2014, HTLV-1学会
ATL細胞におけるCADM1高発現に必須なFN-kB活性化には新規制御因子p47の発現低下が関係する

西片一朗, 市川朝永, 中畑新吾, 藤井雅寛, 伊波英克, 白神俊幸, 田中勇悦, 井上純一郎, 森下和広

第1回HTLV-1学会総会, Aug 24, 2014, HTLV-1学会
血中CADM1/TSLC1測定によるATL診断法の開発

中武彩子, 小林行治, 西片一朗, 中畑新吾, 岩永正子, 相良康子, 北中明, 天野正弘, 前田宏一, 末岡栄三朗, 瀬戸山充, 岡山昭彦, 宇都宮與, 下田和哉, 渡邉俊樹, 森下和広

第6回HTLV-1研究会集会, Aug 24, 2013, HTLV-1研究会
ATL細胞におけるCADM1高発現はHTLV-1Taxを含むNF-kB活性化に依存する

西片一朗, 市川朝永, 中畑新吾, 藤井雅寛, 伊波英克, 白神俊幸, 田中勇悦, 森下和広

第6回HTLV-1研究会集会, Aug 24, 2013, HTLV-1研究会
T細胞特異的TSLC1 TgマウスはATL様病態を示す

市川朝永, 中畑新吾, 山口良二, 西片一朗, 森下和広

第4回HTLV-1研究会集会, Sep 18, 2011, HTLV-1研究会
急性骨髄性白血病の原因遺伝子EVI1によるGATA-2転写活性化の機能解析

島原明子, 山川哲生, 齊藤祐介, 西片一朗, 森下和広

日本分子生物学会第9回春季シンポジウム, May 11, 2009, 日本分子生物学会
EVI1依存性GATA-2発現を伴う急性骨髄性白血病の機能解析

島原明子, 山川哲生, 西片一朗, 森下和広

第31回日本分子生物学会年会, Dec, 2008, 日本分子生物学会
EVI1依存性GATA-2発現を伴う急性骨髄性白血病の機能解析

島原明子, 山川哲生, 西片一朗, 森下和広

第30回日本分子生物学会年会, Dec 12, 2007, 日本分子生物学会
白血病細胞におけるEVI1遺伝子依存性GATA-2転写調節

島原明子, 山川哲生, 西片一朗, 森下和広

日本分子生物学会2006フォーラム, Dec 8, 2006, 日本分子生物学会
EVI1高発現白血病細胞におけるGATA-2遺伝子の転写活性化機構の検討

島原明子, 西片一朗, 森下和広

第28回日本分子生物学会年会, Dec 7, 2005, 日本分子生物学会
EVI1/MEL1遺伝子群によるGATA-2遺伝子調節と白血病発症機構の解析

西片一朗, 湯浅博美, 尾池雄一, 須田年生, 森下和広

第27回日本分子生物学会年会, Dec 10, 2004, 日本分子生物学会
MEL1Sによる骨髄細胞分化阻害のHDAC阻害剤Trichostatin Aによる回復

西片一朗, 佐々木秀法, 阿野仁志, 森下和広

第26回日本分子生物学会年会, Dec 10, 2003, 日本分子生物学会
t(1;3)(p36;q21)を伴うAMLでは主にPR domain を欠いたMEL1が発現している

西片一朗, 佐々木秀法, 阿野仁志, 森下和広

第25回日本分子生物学会年会, Dec 11, 2002, 日本分子生物学会
白血病化に関する新規zinc finger protein MEL1 の単離と機能解析

西片一朗, 森下和広

第23回日本分子生物学会年会, Dec 13, 2000, 日本分子生物学会

Teaching Experience

生化学 (九州保健福祉大学)

Professional Memberships

Research Projects

Analysis of ATL leukemogenesis through breakage of defense mechanism of HTLV-1 infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Kazuhiro Morishita, TANIWAKI Masfumi, NAKAHATA Shingo, ICHIKAWA Tomonaga, KANEDA Kazuko, NISHIKATA Ichiro
Pathologic analysis of Adult T-cell leukemia/lymphoma (ATL) usung TSLC1/CAV1, novel secreting proteins related to exosome

Grants‐in‐Aid for Scientific Research of Priority Area from the Ministry of Education, Culture, Sports, Science and Technology in Japan, Grant-in-Aid for Scientific Research (C), The Japan Society for the Promotion of Science, 2013 - 2015

Ichiro Nishikat, Kazuhiro Morishi
Molecular analysis of leukemogenesis of adult-T cell leukemia by genomic abnormalities

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

MORISHITA Kazuhiro, TANIWAKI Masafumi, NAKAHATA Shingo, NISHIKATA Ichiro
超高感度マルチ発光 ELISA 法応用した翻訳後修飾 SUMO 化多重同時評価システムの構築

地域イノベーション創出総合支援事業重点地域研究開発推進プログラム, 平成21年度「シーズ発掘試験」, 独立行政法人科学技術振興機構, 2009 - 2009

西片一朗
Evi1遺伝子群による細胞接着を介した白血病幹細胞維持機構の解明

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

森下和広, 山川哲生, 中畑新吾, 西片一朗
Analysis of leukemogenesis by MELS in MEL-EVI1 gene family

Grants‐in‐Aid for Scientific Research of Priority Area from the Ministry of Education, Culture, Sports, Science and Technology in Japan, Grant-in-Aid for Scientific Research (C), The Japan Society for the Promotion of Science, 2006 - 2007

Ichiro Nishikat, Kazuhiro Morishi
ルシフェラーゼ融合 p53 と His タグ p53 蛋白質を組み合わせ超高感度 p53-Dual ELISA 法の開発とがん診断への応用

地域イノベーション創出総合支援事業重点地域研究開発推進プログラム, 平成18年度「シーズ発掘試験」, 独立行政法人科学技術振興機構, 2006 - 2006

西片一朗
EVI1遺伝子群によるGATA2転写制御と白血病発症機構の解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

森下和広, 西片一朗, 白神俊幸
Analysis leukemogenesis by the expression of EVI1/MEL1S, the PR domain-defective proteins, in EVI1/MEL1 gene family

Grants‐in‐Aid for Scientific Research of Priority Area from the Ministry of Education, Culture, Sports, Science and Technology in Japan, Grant-in-Aid for Scientific Research (C), The Japan Society for the Promotion of Science, 2004 - 2005

Ichiro Nishikat, Toshiyuki Shiraga, Kazuhiro Morishi
Studies for the Practical Use of Novel and Ultrasensitive Enzyme Immunoassay (Immune Complex Transfer Enzyme Immunoassay) of Anti-HTLV-I IgG Using Synthetic Peptides as Antigens

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1996 - 1997

HASHIDA Seiichi, NISHIKATA Ichiro
超高感度酵素免疫測定法の開発とその応用
白血病化に関係する新規zinc finger protein MEL1の単離と機能解析
Development and application of ultrasensitive enzyme immunoassay
Isolation and charactarization of a novel zinc finger protein, MEL1. associated with leukemogenesis.

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Research Interests

Research Areas

Research History

Papers

Misc.

Presentations

Teaching Experience

Professional Memberships

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