NAKAYAMA Toshinori

J-GLOBAL         Last updated: Nov 11, 2019 at 09:25
 
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Name
NAKAYAMA Toshinori
Affiliation
Chiba University
Section
School of Medicine
Job title
Chiba University
Degree
Doctor of Medicine(The University of Tokyo)
Research funding number
50237468

Research Areas

 
 

Published Papers

 
Ichikawa T, Hirahara K, Kokubo K, Kiuchi M, Aoki A, Morimoto Y, Kumagai J, Onodera A, Mato N, Tumes DJ, Goto Y, Hagiwara K, Inagaki Y, Sparwasser T, Tobe K, Nakayama T
Nature immunology      Oct 2019   [Refereed]
Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A
European journal of immunology   49(10) 1457-1973   Oct 2019   [Refereed]
Ihara F, Sakurai D, Takami M, Kamata T, Kunii N, Yamasaki K, Iinuma T, Nakayama T, Motohashi S, Okamoto Y
Cancer immunology, immunotherapy : CII      Oct 2019   [Refereed]
Kimura MY, Koyama-Nasu R, Yagi R, Nakayama T
Seminars in immunopathology   41(3) 349-358   May 2019   [Refereed]
Hirahara K, Shinoda K, Morimoto Y, Kiuchi M, Aoki A, Kumagai J, Kokubo K, Nakayama T
Frontiers in immunology   10 570   Mar 2019   [Refereed]
Hirahara K, Aoki A, Morimoto Y, Kiuchi M, Okano M, Nakayama T
Seminars in immunopathology   41(3) 339-348   May 2019   [Refereed]
Tumes D, Hirahara K, Papadopoulos M, Shinoda K, Onodera A, Kumagai J, Yip KH, Pant H, Kokubo K, Masahiro K, Aoki A, Obata-Ninomiya K, Tokoyoda K, Endo Y, Kimura MY, Nakayama T
The Journal of allergy and clinical immunology      Mar 2019   [Refereed]
Harada K, Ihara F, Takami M, Kamata T, Mise N, Yoshizawa H, Hishiki T, Saito T, Terui K, Nakata M, Komatsu S, Ikeuchi T, Nakayama T, Yoshida H, Motohashi S
Cancer science   110(3) 888-902   Mar 2019   [Refereed]
Pillai MR, Mihi B, Ishiwata K, Nakamura K, Sakuragi N, Finkelstein DB, McGargill MA, Nakayama T, Ayabe T, Coleman ML, Bix M
PloS one   14(2) e0211244   2019   [Refereed]
Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K
Drug design, development and therapy   13 555-568   2019   [Refereed]
Makita Y, Kunii N, Sakurai D, Ihara F, Motohashi S, Suzuki A, Nakayama T, Okamoto Y
BMC cancer   18(1) 1254   Dec 2018   [Refereed]
Wada T, Hirahara K, Aoki A, Morimoto Y, Kiuchi M, Kumagai J, Okano M, Kokubo K, Kato M, Fukano C, Ohashi-Doi K, Nakayama T
Journal of immunological methods   465 53-60   Dec 2018   [Refereed]
Takami M, Cunha C, Motohashi S, Nakayama T, Iwashima M
European journal of immunology   48(12) 1938-1943   Dec 2018   [Refereed]
Tanaka K, Kanesaka Y, Takami M, Suzuki A, Hosokawa H, Onodera A, Kamata T, Nagato K, Nakayama T, Yoshino I, Motohashi S
Biochemical and biophysical research communications   506(1) 27-32   Nov 2018   [Refereed]
Mita Y, Kimura MY, Hayashizaki K, Koyama-Nasu R, Ito T, Motohashi S, Okamoto Y, Nakayama T
International immunology   30(12) 559-567   Nov 2018   [Refereed]
Hirahara K, Mato N, Hagiwara K, Nakayama T
Journal of leukocyte biology   104(5) 895-901   Nov 2018   [Refereed]
Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H
Allergology international : official journal of the Japanese Society of Allergology   68(1) 17-25   Oct 2018   [Refereed]
Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou HK, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T
Nature communications   9(1) 4231   Oct 2018   [Refereed]
Obata-Ninomiya K, Ishiwata K, Nakano H, Endo Y, Ichikawa T, Onodera A, Hirahara K, Okamoto Y, Kanuka H, Nakayama T
Proceedings of the National Academy of Sciences of the United States of America   115(42) E9849-E9858   Oct 2018   [Refereed]
Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy.
Ihara F, Sakurai D, Yonekura S, Iinuma T, Yagi R, Sakurai T, Ito T, Matsuura A, Morimoto Y, Arai T, Suzuki S, Katayama K, Nakayama T, Okamoto Y.
Allergy   73(9) 1823-1832   Sep 2018   [Refereed]

Misc

 
肺移植の拒絶反応における免疫チェックポイント分子を用いた免疫寛容の誘導に向けての基礎研究
海寳 大輔, 鈴木 秀海, 椎名 裕樹, 田中 教久, 山本 高義, 坂入 祐一, 和田 啓伸, 中島 崇裕, 木内 政宏, 本橋 新一郎, 中山 俊憲, 吉野 一郎
移植   54(総会臨時) 263-263   Sep 2019
【アレルギーの分子細胞機構】エフェクター、メモリーTh2細胞の誘導と維持のエピジェネティクス
小久保 幸太, 小野寺 淳, 中山 俊憲
臨床免疫・アレルギー科   72(2) 117-121   Aug 2019
【新時代が始まった-アレルギー疾患研究 疾患多様性を理解し病態の層別化に基づく治療を実現する】(第1章)アレルギーのメカニズム研究 免疫細胞とサイトカインなど アレルギー性気道炎症の病態形成におけるPathogenic Th2細胞の多様な役割
青木 亜美, 平原 潔, 中山 俊憲
実験医学   37(10) 1561-1566   Jun 2019
CD4陽性T細胞(ヘルパーT細胞;Th細胞)は外来異物に対する宿主防御機構として獲得免疫応答の中心を担う一方、多くのアレルギー疾患の発症や病態形成に関与している。かつては1型Th細胞(Th1)と2型Th細胞(Th2)の不均衡がアレルギー疾患をはじめとする慢性炎症疾患の発症メカニズムとして理解されてきた。しかし近年、Th細胞が多様なサブセットと可塑性を有することが明らかになるにあたり、古典的なTh1/Th2バランス破綻モデルではアレルギー疾患の発症機序を十分説明することができないことがわかっ...
専門医のためのアレルギー学講座 免疫学における基礎と新たな展開 病原性Th細胞
森本 侑樹, 平原 潔, 中山 俊憲
アレルギー   68(3) 138-143   May 2019
【医療の近未来予想図】 若手研究者・研究医の活躍が拓く未来医療 千葉大学での「治療学」研究の推進と人材育成
中山 俊憲
日本医事新報   (4958) 49-49   May 2019
異所性結膜リンパ濾胞構造を伴う実験的アレルギー性結膜炎モデルの作成
横山 美樹子, 平原 潔, 中山 俊憲, 海老原 伸行
日本眼科学会雑誌   123(臨増) 248-248   Mar 2019
【呼吸器病学TOPICS 2018-19】 アレルギー・免疫・炎症 線維化誘導-病原性ヘルパーT細胞による気道周囲の線維化誘導機構
平原 潔, 森本 侑樹, 中山 俊憲
分子呼吸器病   23(1) 10-12   Mar 2019
慢性好酸球性副鼻腔炎における線維化誘導 病原性ヘルパーT細胞による組織線維化誘導機構
平原 潔, 森本 侑樹, 中山 俊憲
鼻アレルギーフロンティア   19(1) 20-22   Feb 2019
【免疫と代謝(イムノメタボリズム)】 脂肪酸代謝によるT細胞分化のユニークな制御
遠藤 裕介, 中山 俊憲
炎症と免疫   27(1) 14-18   Dec 2018
近年、脂肪組織のみならず、がんや炎症病態などの疾患局所においても代謝-免疫システムのクロストークの重要性が明らかとなっている。免疫細胞のなかでもT細胞は、分化段階によって細胞サイズ・増殖能・サイトカイン産生などの細胞特性が劇的に変化することから、代謝の影響を最も強く受ける細胞の一つである。本稿では、T細胞の分化・機能獲得における代謝、とりわけ「脂肪酸代謝」の重要性を概説し、そのユニークな作用について論じる。また筆者らが発見したT細胞分化を司る脂肪酸代謝メタボリックリプログラミングの分子制御...

Conference Activities & Talks

 
Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells
NAKAYAMA Toshinori
6th Pediatric Allergy and Asthma Meeting   17 Oct 2019   
Pathogenic tissue resident CD4 T cells in lung fibrosis [Invited]
NAKAYAMA Toshinori
9th International Conference on Autoimmunity   13 Oct 2019   
IL-25, 33, TSLP [Invited]
NAKAYAMA Toshinori
10 Aug 2019   
Pathogenesis and fibrosis of alergic airway inflammation induced by Pathogenic Th 2 cells [Invited]
NAKAYAMA Toshinori
The 40th Annual meeting of the Japanese Society of Inflammation and Regeneration   16 Jul 2019   
Pathogenesis and fibrosis of asthma by memory-type pathogenic Th2 cells
NAKAYAMA Toshinori
Asthma Seminar for emerging talents   25 Jun 2019   
From the Vewpoint of Adaptive Immunity
NAKAYAMA Toshinori
SANOFI Asthma Forum   23 Jun 2019   
Pathogenic Th2 (Tpath2) cells in the airway: Fibrosis-inducing Tpath2 cells
NAKAYAMA Toshinori
University of Southern California   22 Apr 2019   
Pathogenic Th2 (Tpath2) cells in airway inflammation: fibrosis-inducing Tpath2 cells
NAKAYAMA Toshinori
Keystone Symposia on Molecular and Cellular Biology   24 Mar 2019   
Memory-type pathogenic Th2 (Tpath2) cells in the airway: a fibrosis-inducing Tpath2 cell subset [Invited]
NAKAYAMA Toshinori
Severe Asthma Expert Meeting Embassy of Sweden   24 Mar 2019   
Pathogenesis and fibrosis of asthma by memory-type pathogenic Th2 cells [Invited]
NAKAYAMA Toshinori
Asthma Seminar for emerging talents   14 Mar 2019   
Memory type pathogenic Th2 (Tpath2) cells in airway inflammation: Distinction between Tpath2 cells and ILC2 [Invited]
NAKAYAMA Toshinori
3rd cMAV CU-UCSD Symposium   14 Feb 2019   
Epigenetics in the induction and maintenance of effector and memory Th2 cells
NAKAYAMA Toshinori
12 Dec 2018   
Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells
NAKAYAMA Toshinori
32nd Symposium of the Collegium Internationale Allergologium   2 Oct 2018   
Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells.
NAKAYAMA Toshinori
Immunochemistry and Immunobiology Gordon Research Conference   13 Jun 2018   
Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation
NAKAYAMA Toshinori
The 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS 2017)   30 Oct 2017   
Keynote lecture: Memory-type pathogenic Th2 (Tpath2) cells in airway inflammation [Invited]
NAKAYAMA Toshinori
5th Anniversary of the Japan Center for Health Professions Education and Research in Japan Week   3 May 2017   
Memory type pathogenic Th2 cells in airway inflammation
NAKAYAMA Toshinori
The Inaugural Chiba University - UCSD Symposium on Mucosal Immunology, Allergy and Vaccines: Impact on Mucosal Diseases and Global Health   21 Feb 2017   
難治性アレルギ−疾患発症のメカニズム [Invited]
NAKAYAMA Toshinori
SCIENTIFIC EXCHANGE MEETING IN TOKYO   16 Feb 2017   
Generation and maintenance of pathogenic Th2 (Tpath2) cells in chronic allergic airway inflammation [Invited]
NAKAYAMA Toshinori
The 19th Takeda Science Foundation Symposium on Bioscience   20 Jan 2017   
Pathogenic Th2 (Tpath2) cells in airway inflammation: Fibrosis inducing Tpath2 cells.
NAKAYAMA Toshinori
31st Symposium of the Collegium Internationale Allergologium   8 Apr 2016   

Research Grants & Projects

 
Regulation of memory T cell generation and function by fatty acid metabolism
MEXT/Japan Society for the Promotion of Science: 
Project Year: Jun 2018 - Mar 2022    Investigator(s): NAKAYAMA Toshinori
Generation and Maintenance of Pathogenic Immunological Memory and its Regulation
MEXT/Japan Society for the Promotion of Science: 
Project Year: May 2014 - Mar 2019    Investigator(s): Toshinori Nakayama
in vivo live imaging of infiltrated lymphocytes into the lung and liver
MEXT/Japan Society for the Promotion of Science: 
Project Year: 2011 - 2012    Investigator(s): NAKAYAMA Toshinori