Yasutoshi Koga

Profile Information

Affiliation: Associate Professor, School of Medicine, School of Medicine, Department of Pediatrics and Child Health, Kurume University

Degree: (BLANK)

J-GLOBAL ID: 200901012718053206
researchmap Member ID: 1000180669

External link: http://www.med.kurume-u.ac.jp/med/ped/group/index.html

Research Interests

Research Areas

Research History

Mar, 2008 - Present

Professor, Department of Pediatrics and Child Health, Kurume University
Oct, 2003 - Feb, 2008

Associate Professor, Department of Pediatrics and Child Health, Kurume University
Apr, 1996 - Sep, 2003

assistant professor, Department of Pediatrics and Child Health, Kurume University
Jul, 1993 - Mar, 1995

Associate Professor, Department of Neurology, College of Physicians and Surgeons, Columbia University
Apr, 1989 - Jun, 1993

Post-doctoral research fellow, Department of Neurology, College of Physicians and Surgeons, Columbia University
Jul, 1987 - Mar, 1989

Post-doctoral research fellow, Division of Ultrastructural Research, Neuroscience Research Center, Nationa Center of Neurology and Psychiatry
Apr, 1984 - Jun, 1987

research fellow, Department of Pediatrics and Child Health, Kurume University

Education

Apr, 1980 - Mar, 1984

Medicine, Medicine, Graduate School of Kurume University
- 1984

Graduate School, Division of Medicine, Kurume University
Apr, 1974 - Mar, 1980

School of Medicine, School of Medicine, Kurume University
- 1980

Faculty of Medicine, Kurume University

Committee Memberships

Awards

Jun, 2014

Kelsey Wright Award, New biomarker GDF15 for diagnosis of mitochondrial disorders., United Mitochondrial Disease Foundation

KOGA Yasutoshi
Jan, 2010

award of Fukuoka Medical Association, L-arginine therapy for MELAS, Fukuoka Medical Association

KOGA Yasutoshi
2008

best research awards, Molecular Pathology of Mitochondrial Disorders, Japanese Society of Mitochondrial Research and Medicine

KOGA Yasutoshi
2008

Kersy Wright Award, L-arginine therapy for MELAS, United Mitochondrial Disease Foundation

KOGA Yasutoshi
2000

国際神経筋学会
1992

New York Academy of Medicine (USA), David-Warfield Fellowship
1989

Muscular Dystrophy Association (USA), Post-doctoral Research Fellowship
1989

Research Fellow for Abroad, Molecular Pathology of Mitochondrial Disorders, Uehara Memorial Research Foundation

KOGA Yasutoshi
1984

日本先天代謝異常学会

Papers

Developmental delay and failure to thrive in a 7-month-old baby boy with spontaneous transient Graves' thyrotoxicosis: A case report

Shuichi Yatsuga, Tomoko Saikusa, Takako Sasaki, Kikumi Ushijima, Miyuki Kitamura, Junko Nishioka, Yasutoshi Koga

Journal of Medical Case Reports, 10(1) 219, Oct 8, 2016 Peer-reviewed
Mitochondrial diseases

Grainne S. Gorman, Patrick F. Chinnery, Salvatore DiMauro, Michio Hirano, Yasutoshi Koga, Robert McFarland, Anu Suomalainen, David R. Thorburn, Massimo Zeviani, Douglass M. Turnbull

NATURE REVIEWS DISEASE PRIMERS, 2 1-22, Oct, 2016 Peer-reviewed
L-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS

Miyuki Kitamura, Shuichi Yatsuga, Toshi Abe, Nataliya Povalko, Reo Saiki, Kikumi Ushijima, Yushiro Yamashita, Yasutoshi Koga

JOURNAL OF NEUROLOGY, 263(8) 1666-1668, Aug, 2016 Peer-reviewed
Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes

Takaaki Murakami, Yoko Ueba, Yuya Shinoto, Yasutoshi Koga, Daita Kaneda, Tomonobu Hatoko, Tomoko Kato, Shin Yonemitsu, Seiji Murol, Shogo Okil

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 239(2) 89-94, Jun, 2016 Peer-reviewed
Pyruvate Improved Insulin Secretion Status in a Mitochondrial Diabetes Mellitus Patient

Takeshi Inoue, Nobuyuki Murakami, Tadayuki Ayabe, Yuji Oto, Ichizo Nishino, Yu-ichi Goto, Yasutoshi Koga, Ryoichi Sakuta

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101(5) 1924-1926, May, 2016 Peer-reviewed
Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes

Takaaki Murakami, Yuya Shinoto, Shin Yonemitsu, Seiji Muro, Shogo Oki, Yasutoshi Koga, Yu-ichi Goto, Daita Kaneda

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 238(4) 311-316, Apr, 2016 Peer-reviewed
ADHD-like behavior in a patient with hypothalamic hamartoma

Koujyu Katayama, Yushiro Yamashita, Shuichi Yatsuga, Yasutoshi Koga, Toyojiro Matsuishi

BRAIN & DEVELOPMENT, 38(1) 145-148, Jan, 2016 Peer-reviewed
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

Shuichi Yatsuga, Yasunori Fujita, Akiko Ishii, Yoshihiro Fukumoto, Hajime Arahata, Tatsuyuki Kakuma, Toshio Kojima, Masafumi Ito, Masashi Tanaka, Reo Saiki …

ANNALS OF NEUROLOGY, 78(5) 814-823, Nov, 2015 Peer-reviewed
New TRPM6 mutation and management of hypomagnesaemia with secondary hypocalcaemia

Koujyu Katayama, Nataliya Povalko, Shuichi Yatsuga, Junko Nishioka, Tatsuyuki Kakuma, Toyojiro Matsuishi, Yasutoshi Koga

BRAIN & DEVELOPMENT, 37(3) 292-298, Mar, 2015 Peer-reviewed
Cdk5rap1-Mediated 2-Methylthio Modification of Mitochondrial tRNAs Governs Protein Translation and Contributes to Myopathy in Mice and Humans

Fan-Yan Wei, Bo Zhou, Takeo Suzuki, Keishi Miyata, Yoshihiro Ujihara, Haruki Horiguchi, Nozomu Takahashi, Peiyu Xie, Hiroyuki Michiue, Atsushi Fujimura …

CELL METABOLISM, 21(3) 428-442, Mar, 2015 Peer-reviewed
GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

Yasunori Fujita, Masafumi Ito, Toshio Kojima, Shuichi Yatsuga, Yasutoshi Koga, Masashi Tanaka

MITOCHONDRION, 20 34-42, Jan, 2015 Peer-reviewed
Efficacy of pyruvate therapy in patients with mitochondrial disease: A semi-quantitative clinical evaluation study

Tatsuya Fujii, Fumihito Nozaki, Keiko Saito, Anri Hayashi, Yutaka Nishigaki, Kei Murayama, Masashi Tanaka, Yasutoshi Koga, Ikuko Hiejima, Tomohiro Kumada

MOLECULAR GENETICS AND METABOLISM, 112(2) 133-138, Jun, 2014 Peer-reviewed
[The treatment of mitochondrial disorders, present and future].

Koga Y

Nihon rinsho. Japanese journal of clinical medicine, 72(1) 175-184, Jan, 2014 Peer-reviewed
Glycogenic hepatopathy and non-alcoholic fatty liver disease in type 1 diabetes patients

Mamoru Saikusa, Shuichi Yatsuga, Tatsuyuki Tonan, Yasutoshi Koga

Pediatrics International, 55(6) 806-807, 2013 Peer-reviewed
MELAS: a nationwide prospective cohort study of 96 patients in Japan.

Yatsuga S, Povalko N, Nishioka J, Katayama K, Kakimoto N, Matsuishi T, Kakuma T, Koga Y, Taro Matsuoka for, MELAS Study …

Biochimica et biophysica acta, 1820(5) 619-624, May, 2012 Peer-reviewed
Molecular pathology of MELAS and L-arginine effects.

Koga Y, Povalko N, Nishioka J, Katayama K, Yatsuga S, Matsuishi T

Biochimica et biophysica acta, 1820(5) 608-614, May, 2012 Peer-reviewed
Biochemistry of mitochondria, life and intervention 2010.

Koga Y, Tanaka M, Ohta S, Wei YH

Biochimica et biophysica acta, 1820(5) 551-552, May, 2012 Peer-reviewed
Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1 alpha gene

Yasutoshi Koga, Nataliya Povalko, Koujyu Katayama, Noriko Kakimoto, Toyojiro Matsuishi, Etsuo Naito, Masashi Tanaka

BRAIN & DEVELOPMENT, 34(2) 87-91, Feb, 2012 Peer-reviewed
Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA

Masamichi Ikawa, Kenichiro Arakawa, Tadanori Hamano, Miwako Nagata, Yasunari Nakamoto, Masaru Kuriyama, Yasutoshi Koga, Makoto Yoneda

EUROPEAN NEUROLOGY, 67(4) 232-237, 2012 Peer-reviewed
A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves disease: A case report

Shuichi Yatsuga, Yuji Hiromatsu, Shigekazu Sasaki, Hirotoshi Nakamura, Koju Katayama, Junko Nishioka, Yasutoshi Koga

Journal of Medical Case Reports, 6 246, 2012 Peer-reviewed

Misc.

314

【小児疾患診療のための病態生理 3 改訂第5版】筋疾患ミトコンドリア病分子病態と創薬の最前線

古賀靖敏

小児内科, 48(増刊) 540-550, Nov, 2016
MELAS脳卒中様発作時のL-アルギニン療法は早期投与ほど予後を改善する

喜多村美幸, 八ツ賀秀一, 佐々木孝子, 牛嶋規久美, 齊木玲央, 古賀靖敏, 山下裕史朗

日本小児科学会雑誌, 120(10) 1567-1567, Oct, 2016
【先天代謝異常症-エキスパートによる最新情報-】各疾患の進歩ミトコンドリア病の治療

古賀靖敏

小児科診療, 79(6) 797-803, Jun, 2016
急性血液浄化・腹膜透析を行った乳児致死型ミトコンドリア心筋症の新生児症例

江崎拓也, 田中征治, 財津亜友子, 島さほ, 木下正啓, 岩田欧介, 前野泰樹, 八ツ賀秀一, 古賀靖敏, 山下裕史朗

日本小児腎臓病学会雑誌, 29(1Suppl.) 114-114, Jun, 2016
ジストロフィン遺伝子解析(MLPA法)でレアバリアントによるエクソン22の増幅不良を認めた1例

喜多村美幸, 八ツ賀秀一, 佐々木孝子, 古賀靖敏, 李知子, 竹島泰弘

日本小児科学会雑誌, 120(5) 937-937, May, 2016
ミトコンドリア病創薬の最前線

古賀靖敏

脳と発達, 48(Suppl.) S183-S183, May, 2016
【小児慢性疾患の成人期移行の現状と問題点】神経・筋疾患ミトコンドリア脳筋症全科を巻き込む体制、「もう赤ひげは要らない」体制づくり

古賀靖敏

小児科臨床, 69(4) 735-741, Apr, 2016
【小児の症候群】神経・精神ミトコンドリアDNA枯渇症候群

古賀靖敏

小児科診療, 79(増刊) 141-142, Apr, 2016
小児内分泌疾患におけるFGF21の検討

八ツ賀秀一, 佐々木孝子, 西岡淳子, 牛嶋規久美, 喜多村美幸, 古賀靖敏

日本内分泌学会雑誌, 92(1) 322-322, Apr, 2016
日本人ミトコンドリア脳筋症患者において先行する糖尿病は認知機能低下に影響する

村上隆亮, 波床朋信, 加藤朋子, 米光新, 武呂誠司, 隠岐尚吾, 古賀靖敏, 金田大太

糖尿病, 59(Suppl.1) S-152, Apr, 2016
MELAS脳卒中様発作超急性期のLアルギニン静注療法は症状とMRI異常を改善する

喜多村美幸, 八ツ賀秀一, 佐々木孝子, 牛嶋規久美, 齊木玲央, 古賀靖敏

日本小児科学会雑誌, 120(2) 337-337, Feb, 2016
ピルビン酸ナトリウム治療評価における新規バイオマーカーGDF-15の有用性

古賀靖敏, 八ツ賀秀一, 西岡淳子, 佐々木孝子, 齋木玲央, 牛嶋規久美, 喜多村美幸, 田中雅嗣

日本小児科学会雑誌, 120(2) 337-337, Feb, 2016
リンパ球性下垂体後葉炎が原因で尿崩症を呈したと考えられる小児の2例

佐々木孝子, 岩元二郎, 一ノ瀬英世, 牛嶋規久美, 喜多村美幸, 片山幸樹, 八ツ賀秀一, 西岡淳子, 古賀靖敏

日本小児科学会雑誌, 120(2) 345-345, Feb, 2016
愛情遮断症候群により可逆性の成長ホルモン分泌低下を来したと思われる9歳男児

牛嶋規久美, 八ツ賀秀一, 佐々木孝子, 喜多村美幸, 古賀靖敏

日本小児科学会雑誌, 120(2) 346-346, Feb, 2016
TSH異常高値マクロTSH血症と診断した4歳男児

西岡淳子, 八ツ賀秀一, 早田峰子, 佐々木孝子, 牛嶋規久美, 喜多村美幸, 中島正幸, 古賀靖敏, 山下裕史朗

日本小児科学会雑誌, 120(2) 349-349, Feb, 2016
高度肥満から虐待が疑われ迅速に対応できた3歳女児例

八ツ賀秀一, 家村明子, 須田正勇, 松石登志哉, 佐々木孝子, 西岡淳子, 古賀靖敏, 山下裕史朗

日本小児科学会雑誌, 120(2) 398-398, Feb, 2016
メラノコルチン2型受容体(MC2R)異常によるACTH不応症の男児の一例

冨田舞, 天野直子, 鳴海覚志, 長谷川奉延, 岡田純一郎, 久野正, 佐々木孝子, 八ツ賀秀一, 牛嶋規久美, 古賀靖敏

日本小児科学会雑誌, 120(2) 474-474, Feb, 2016
C3303T変異による乳児致死型ミトコンドリア心筋症の一例

島さほ, 木下正啓, 七種護, 岩田欧介, 前野泰樹, 江崎拓也, 田中征治, 八ツ賀秀一, 古賀靖敏, 山下裕史朗

日本小児科学会雑誌, 120(2) 484-484, Feb, 2016
新生児期の頻脈を契機に甲状腺ホルモン不応症と診断した一例

進藤亮太, 岡田純一郎, 田中祥一朗, 多々良一彰, 佐々木孝子, 八ツ賀秀一, 古賀靖敏, 久野正

日本小児科学会雑誌, 120(2) 487-487, Feb, 2016
ピルビン酸ナトリウムによるミトコンドリア病に合併した高乳酸血症治療薬の開発

古賀靖敏

臨床評価, 43(2) 450-453, Jan, 2016

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