2020年4月1日
Total Syntheses of Marrubiin and Related Labdane Diterpene Lactones
Molecules
- ,
- ,
- ,
- ,
- 巻
- 25
- 号
- 7
- 開始ページ
- 1610
- 終了ページ
- 1610
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/molecules25071610
- 出版者・発行元
- MDPI AG
Total syntheses of the labdane diterpene lactones marrubiin, marrulibacetal, desertine, marrulibacetal A, marrubasch F, cyllenine C, marrulanic acid, and marrulactone are described. The trans-decalin moiety of these molecules was constructed in a stereoselective manner by a Pauson-Khand reaction, and the resultant cyclopentenone was oxidatively cleaved for formation of the lactone ring. Elongation of the side chain at C9 was achieved by an epoxide-opening reaction with a variety of nucleophiles, and the functional group manipulations completed the syntheses of these natural products. Stereochemistries of desertine could be established by the transformations.
- ID情報
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- DOI : 10.3390/molecules25071610
- eISSN : 1420-3049