2008年2月
Brain maturation-related spike localization in Panayiotopoulos syndrome: Magnetoencephalographic study
PEDIATRIC NEUROLOGY
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- 巻
- 38
- 号
- 2
- 開始ページ
- 104
- 終了ページ
- 110
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.pediatrneurol.2007.08.020
- 出版者・発行元
- ELSEVIER SCIENCE INC
Focal spike activities in Panayiotopoulos syndrome involve all brain regions in electroencephalography, and commonly reveal multiple foci, often through occipital predominance. To investigate correlations between developmental brain maturation and spike origin in Panayiotopoulos syndrome, we evaluated age-related or duration-related magnetoencephalographic spike localization in 25 patients with Panayiotopoulos syndrome. Regarding age at examination, patients with frontal spikes were significantly older than patients with spikes on rolandic, parieto-occipital, or calcarine sulci. Occipital spikes were classified into two subgroups, located at the calcarine sulcus and parieto-occipital sulcus. Both calcarine and parieto-occipital localizations were seen in patients around the same age. Follow-up magnetoencephalography was performed on three patients, and demonstrated shifting localization or disappearance of magnetoencephalographic spikes. These results suggest that the location of spike discharges is not directly related to seizure symptoms, but instead indicates maturation-related cortical hyperexcitability in patients with Panayiotopoulos syndrome. (c) 2008 by Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.pediatrneurol.2007.08.020
- ISSN : 0887-8994
- Web of Science ID : WOS:000252792800005