HAMAKUBO Takao

J-GLOBAL         Last updated: Sep 27, 2018 at 14:14
 
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Name
HAMAKUBO Takao
Affiliation
Nippon Medical School
Job title
professor
Degree
(BLANK)

Research Areas

 

Education

 
 
 - 
1987
Graduate School, Division of Medicine, Kyoto University
 
 
 - 
1982
Faculty of Medicine, Kyoto University
 

Published Papers

 
Akiba H, Ikeuchi E, Ganbat J, Fujikawa H, Arai-Kusano O, Iwanari H, Nakakido M, Hamakubo T, Shimomura Y, Tsumoto K
Journal of structural biology      Aug 2018   [Refereed]
Kobayashi M, Ohsugi M, Sasako T, Awazawa M, Umehara T, Iwane A, Kobayashi N, Okazaki Y, Kubota N, Suzuki R, Waki H, Horiuchi K, Hamakubo T, Kodama T, Aoe S, Tobe K, Kadowaki T, Ueki K
Molecular and cellular biology   38(16)    Aug 2018   [Refereed]
Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S
Nature structural & molecular biology   25(7) 570-576   Jul 2018   [Refereed]
Miyanabe K, Yamashita T, Abe Y, Akiba H, Takamatsu Y, Nakakido M, Hamakubo T, Ueda T, Caaveiro JMM, Tsumoto K
Biochemistry   57(28) 4177-4185   Jul 2018   [Refereed]
Miyanabe K, Akiba H, Kuroda D, Nakakido M, Kusano-Arai O, Iwanari H, Hamakubo T, Caaveiro JMM, Tsumoto K
Journal of biochemistry   164(1) 65-76   Jul 2018   [Refereed]

Misc

 
工藤翔太, 岩成宏子, 浜窪隆雄, 児玉龍彦, 松浦正, 須藤幸夫, 津本浩平, 津本浩平
日本蛋白質科学会年会プログラム・要旨集   12th 60   May 2012
湯村恭平, 宇井美穂子, 岡本未央, 土井洋文, 杉山暁, 浜窪隆雄, 児玉龍彦, 津本浩平
日本蛋白質科学会年会プログラム・要旨集   12th 106   May 2012
小林正稔, 大杉満, 笹子敬洋, 小林直樹, 岩根亜弥, 粟澤元晴, 岡崎由希子, 堀内恵子, 浜窪隆雄, 児玉龍彦, 戸辺一之, 植木浩二郎, 門脇孝
糖尿病   55(Supplement 1) S.188   Apr 2012
湯村恭平, 宇井美穂子, 岡本未央, 土井洋文, 杉山暁, 浜窪隆雄, 児玉龍彦, 津本浩平
日本化学会講演予稿集   92nd(3) 1059   Mar 2012
橘敬祐, 橘敬祐, 竹内健太郎, 稲田大彦, 杉本研, 石本憲司, 田中十志也, 楽木宏実, 浜窪隆雄, 酒井寿郎, 児玉龍彦, 沢村達也, 沢村達也, 土井健史
日本薬理学会近畿部会プログラム・要旨集   121st 82   2012

Books etc

 
猪飼篤, 伏見譲, 卜部格, 上野川修一, 中村春木, 浜窪隆雄
朝倉書店   Jul 2008   ISBN:4254171285
児玉 龍彦, 浜窪 隆雄 (Part:Joint Work)
講談社   Jun 1997   ISBN:4062571765

Conference Activities & Talks

 
Flow Cytometric Detection of Asparagine Synthetase Protein in Leukemia Cell:Indication for L Asparaginese Therapy
oshiyuki Kitoh, Kou Suchan Gao Siqiang, Masahito Tsurusawa, Hidefumi Kato, Yasuto Shimomura ,Tosinori Hori, Kimiyoshi Sakaguchi, Hirose Miwa, Takao Hamakubo
2013 European Academy of Paediatrics Educational Congress&Mastercourse   19 Sep 2013   
The live cell imaging of GPCR signaling
HAMAKUBO Takao
12 Jun 2013   Vanderbilt University
The WTAP complex is a novel RNA processing factor required for cell cycle progression
Keiko Horiuchi
Gordon conference, The biology of post-transcriptional gene regulation   17 Jul 2012   
Proteomic analysis of circulating pentraxin3 (PTX3) complexes in sepsis revealed the PTX3-NETs complex formation: Implication of new protectiveroles against sepsis
Kenji Daigo, Naotaka Yamaguchi, Takeshi Kawamura, Koichi Matsubara, Shuying Jiang, Riuko Ohashi, Yukio Sudou, Makoto Naito, Kenji Inoue, and Takao Hamakubo
9th International Conference on Innate Immunity   Jun 2012   
Functional Roles of GATA2 in Vascular Biology
Yasuharu Kanki, Shuichi Tsutsumi, Takahide Kohro, Imari Mimura, Takao Hamakubo, Hiroyuki Aburatani, Tatsuhiko Koadama, Takashi Minami
第34回 日本分子生物学会年会   
Design and preparation of core-sreptavidin-fusion antibody for pretargeting drug delivery
Kyohei Yumura, Mihoko Ui, Hirohumi Doi, Akira Sugiyama, Takao Hamakubo, Tatsuhiko Kodama, Kouhei Tsumoto
第34回 日本分子生物学会年会   
放射線免疫療法を指向した抗P-cadherin抗体の物理化学的解析
工藤 翔太, 宮房 孝光, 岩成 宏子, 浜窪 隆雄, 児玉 龍彦, 松浦 正, 須藤 幸夫, 津本 浩平
第34回 日本分子生物学会年会   
A methpd of generating antibodies against exogenously administered self-antigen by manipulating CD4+CD25+ regulatory T cells
Hiroko Iwanari, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Nobuchika Suzuki, Tatsuhiko Kodama, Takao Hamakubo, Toshiko Sakihama
第34回 日本分子生物学会年会   
赤血球膜陰イオン交換輸送体(eAE1)膜ドメインの構造解析に向けた抗体の利用
荒川 隆俊, 小林 貴美, 岩成 宏子, 日野 智也, 名倉 淑子, 波多江 日成子, 隈 博幸, Cameron Alexander, 浜窪 隆雄, 濱崎 直孝, 岩田 想, 小林 拓也, 村田 武士
第84回日本生化学会大会   
Proteomic analysis of pentraxin3 (PTX3) complexes in serum and plasma from septic patients reveals that the neutrophil extracellular traps components are the new PTX3 ligands.
Kenji Daigo, N. Yamaguchi, T. Kawamura, Y. Sudou, K. Inoue, T. Hamakubo
Eleventh International Symposium on Mass Spectrometry in the Health & Life Sciences: Molecular & Cellular Proteomics   
次世代バイオマーカー医薬を目指した抗体作製について [Invited]
浜窪隆雄
第7回ナノバイオ国際シンポジウム   
GATA2 occupancies differ from each cell type, which is correlated with epigenetic modifications and gene expression profiles in cell-type specific manner
Kanki Y,Tsutsumi S,Jiang S,Mimura I,Wada Y,Ihara S,Naito M,Hamakubo T,Aburatani H,Minami T,Kodama T,
BMB2010   
Molecular basis of G−protein coupled inactivation by an allosteric antibody
日野智也,荒川 孝俊,寿野千代,岩成宏子,中田淑子,新井修,キャメロン アレクサンダー,ウェヤンド シモーネ,小林貴美,小林拓也,浜窪隆雄,岩田想,村田武士
BMB2010   
Expression of Angiotensin ? type 2 receptor in dendritic cells
Fujimoto A,Kodama T,Hamakubo,T ,Chiba J
BMB2010   
Expression and purification of Angiotensin receptor type2 and production of structure recognition antibody for structural biology
浅田秀基,小林貴美,白石充典,島村達郎,植村智子,辻本浩一,飛田直美,中根崇智,岩成宏子,新井修,穐本智,中川清,浜窪隆雄,岩田想,小林拓也
BMB2010   
Expression and in vitro characterization of anti-Epiregulin scFv-Fc
田代晋也,宮房孝光,佐野恵海子,吉田賢二,平田裕一,浜窪隆雄,児玉龍彦,津本浩平
BMB2010   
Core streptavidin-fusion-antibody for Pretargeting Drug Delivery
YumuraK, Ui M,Doi H,Sugiyama A,Hamakubo T, Kodama T, Tsumoto K,
BMB2010   
三量体Gタンパク質活性化とRGS相互作用のFRETによる生細胞イメージング
増田一之,北上純一,井原茂男,小笹徹,児玉龍彦,浜窪隆雄
BMB2010   
The role of the G13~RH-RhoGEF signal pathway in differentiation of human myeloid HL60 leukemia cells
Suzuki N,Kawamura T,Iwanari H,Mochizuki Y,Hamakubo T,Kozasa
BMB2010   
Identification of specific phosphorylation sites on p115RhoGEF
Christina R. Chow, Suzuki N,Kawamura T,Hamakubo T, Kozasa T
BMB2010   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(S))
Project Year: 2008 - 2011    Investigator(s): Takao HAMAKUBO
(抄録なし)
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2008    Investigator(s): Sigeo IHARA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2008    Investigator(s): Toshiko SAKIHAMA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2006 - 2007    Investigator(s): Takao HAMAKUBO
Transcription factors or membrane receptor proteins (e. g., the G protein-coupled receptor [GPCR]) are considered to precisely regulate physiological processes by forming complexes with a number of proteins. As the amounts of these proteins, which...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Takao HAMAKUBO
Membrane proteins such as peptide transporter G-protein coupled receptors (BLT1, CCR2, CCR5, Edg1, AT1a, AT2, D1, D5) and their complex (reoeptor-Gs-adenylyl cyclase) or active γ-secretase complex (presenillin-APH1-nicastrin-PEN2) have been succes...

Patents

 
特許4551326 : ペプチドトランスポーターの輸送活性を阻害する抗体
児玉 龍彦・浜窪 隆雄・斎藤 良一・山田 良樹
課題】PepT1およびPepT2の癌細胞増殖への関与は不明であり、PepT1およびPepT2の機能を阻害することにより癌細胞の増殖に影響を与え、ペプチドトランスポーターの輸送活性を阻害する抗体、及び該抗体を有効成分とする細胞増殖抑制剤を提供する。
【解決手段】PepTに結合する抗体がペプチドトランスポーターの輸送活性阻害能を有することが見出された。これらの抗体は、細胞増殖抑制剤として、例えば癌の治療や予防への利用が可能である。