2010 - 2012
The elucidation of molecular mechanisms of amelogenesis by epitherial-specific Runx knockout mouse
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 22390390
- Japan Grant Number (JGN)
- JP22390390
- Grant amount
-
- (Total)
- 19,370,000 Japanese Yen
- (Direct funding)
- 14,900,000 Japanese Yen
- (Indirect funding)
- 4,470,000 Japanese Yen
Targeted deletion of Runx genes has revealed distinct roles for these proteins in development. Here, we report that epithelial Runx genes are involved in regulation of ameloblastdifferentiation. We analyzed the functional role of Cbfb and Runx1 in the enamel formation invivo, using a conditional genetic approach in which the Cbfb and Runx1 gene was inactivated in mouse epithelial cells(K14-Cre/Cbfbfl/fl, K14-Cre/Runx1 fl/fl). We found that mice deficient in epithelial Cbfb and Runx1 resulted in enamel aplasia in the incisors and in hypoplasia in the molars. The present results provide the genetic evidence that Runx1 and Cbfb genes function in the enamel formation in developing molar and incisors.
- Link information
- ID information
-
- Grant number : 22390390
- Japan Grant Number (JGN) : JP22390390