石井邦明 (Kuniaki Ishii) - マイポータル

基本情報

所属: 山形大学医学部医学科薬理学講座教授

学位: 博士(医学)(東北大学)

J-GLOBAL ID: 200901013394157727
researchmap会員ID: 1000183585

外部リンク: http://www.id.yamagata-u.ac.jp/Pharmaco/Pharmacol-JP.html

研究キーワード

研究分野

ライフサイエンス / 薬理学 /

学歴

1982年 - 1986年

東北大学大学院, 医学研究科, （薬理学第二講座）
1975年 - 1981年

東北大学, 医学部, 医学科

論文

KCNQ1 is internalized by activation of α₁ adrenergic receptors.

Kurakami K, Norota I, Nasu F, Ohshima S, Nagasawa Y, Konno Y, Obara Y, Ishii K

Biochemical pharmacology 169 113628-113628 2019年11月査読有り
Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.

Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K

The Journal of biological chemistry 294(44) 16049-16061 2019年11月査読有り
Midnolin is a confirmed genetic risk factor for Parkinson's disease.

Obara Y, Sato H, Nakayama T, Kato T, Ishii K

Annals of clinical and translational neurology 6(11) 2205-2211 2019年11月査読有り
ERK5 Phosphorylates K_v4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells.

Kashino Y, Obara Y, Okamoto Y, Saneyoshi T, Hayashi Y, Ishii K

International journal of molecular sciences 19(7) 2018年7月査読有り
Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson's Disease Causative Genes.

Obara Y, Ishii K

Biological & pharmaceutical bulletin 41(1) 20-23 2018年1月査読有り
Insulin treatment augments KCNQ1/KCNE1 currents but not KCNQ1 currents, which is associated with an increase in KCNE1 expression

Minghua Wu, Yutaro Obara, Shingo Ohshima, Yoshinobu Nagasawa, Kuniaki Ishii

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 493(1) 409-415 2017年11月査読有り
Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease

Yutaro Obara, Toru Imai, Hidenori Sato, Yuji Takeda, Takeo Kato, Kuniaki Ishii

SCIENTIFIC REPORTS 7(1) 5885 2017年7月査読有り
Licochalcones extracted from Glycyrrhiza inflata inhibit platelet aggregation accompanied by inhibition of COX-1 activity

Asa Okuda-Tanino, Daiki Sugawara, Takumi Tashiro, Masaya Iwashita, Yutaro Obara, Takahiro Moriya, Chisato Tsushima, Daisuke Saigusa, Yoshihisa Tomioka, Kuniaki Ishii …

PLOS ONE 12(3) e0173628 2017年3月査読有り
ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells.

Yutaro Obara, Ryusuke Nagasawa, Wataru Nemoto, Michael J Pellegrino, Maho Takahashi, Beth A Habecker, Philip J S Stork, Osamu Ichiyanagi, Hiromi Ito, Yoshihiko Tomita …

Cellular signalling 28(3) 177-189 2016年3月査読有り
Phosphorylation of ERK5 on Thr732 Is Associated with ERK5 Nuclear Localization and ERK5-Dependent Transcription

Takuto Honda, Yutaro Obara, Arata Yamauchi, Anthony D. Couvillon, Justin J. Mason, Kuniaki Ishii, Norimichi Nakahata

PLOS ONE 10(2) e0117914 2015年2月査読有り
Is PIP2 involved in the insulin effect?

Kuniaki Ishii, Minghua Wu, Yutaro Obara

CHANNELS 8(5) 391-392 2014年9月査読有り
Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

Junji Suzuki, Kazunori Kanemaru, Kuniaki Ishii, Masamichi Ohkura, Yohei Okubo, Masamitsu Iino

NATURE COMMUNICATIONS 5 4153 2014年6月査読有り
Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1.

Wu M, Obara Y, Norota I, Nagasawa Y, Ishii K

Pflugers Archiv : European journal of physiology 466(5) 937-946 2014年5月査読有り
[Roles of ERK5 in neuronal cells].

Obara Y, Ishii K

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 141(6) 354-354 2013年6月査読有り
[Multiple functions of Gh/transglutaminase 2].

Obara Y, Ishii K

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 141(4) 225-225 2013年4月査読有り
Gα(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.

Obara Y, Yanagihata Y, Abe T, Dafik L, Ishii K, Nakahata N

Cellular signalling 25(3) 589-597 2013年3月査読有り
Is a novel SCN3B mutation commonly found in SCN5A-negative brugada syndrome patients?

Kazuya Kurakami, Kuniaki Ishii

Circulation Journal 77(4) 900-901 2013年査読有り
Endocytic Regulation of Voltage-Dependent Potassium Channels in the Heart

Kuniaki Ishii, Ikuo Norota, Yutaro Obara

JOURNAL OF PHARMACOLOGICAL SCIENCES 120(4) 264-269 2012年12月査読有り
Wortmannin Inhibits the Increase in Myofilament Ca2+ Sensitivity Induced by Cross-Talk of Endothelin-1 With Norepinephrine in Canine Ventricular Myocardium

Li Chu, Ikuo Norota, Kuniaki Ishii, Masao Endoh

JOURNAL OF PHARMACOLOGICAL SCIENCES 109(2) 193-202 2009年2月査読有り
Cardiac Ion Channel Gene Mutations in Sudden Infant Death Syndrome

Tesshu Otagiri, Kazuki Kijima, Motoki Osawa, Kuniaki Ishii, Naomasa Makita, Ryoji Matoba, Kazuo Umetsu, Kiyoshi Hayasaka

PEDIATRIC RESEARCH 64(5) 482-487 2008年11月査読有り

もっとみる

経歴

2006年 - 現在

山形大学医学部, 薬理学講座, 教授
1996年 - 2005年

山形大学医学部, 薬理学講座, 助教授
1995年 - 1996年

東北大学医学部, 病態生理学講座, 講師
1986年 - 1995年

東北大学医学部助手
1986年 - 1988年

スタンフォード大学, 内科学・薬理学, ポストドクトラフフェロー
1981年 - 1982年

東北大学医学部附属病院, 第一内科学, 研修医

MISC

Roles of ERK5 in ion channel expression in PC12 cells

Kashino Yurina, Obara Yutaro, Ishii Kuniaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 133(3) S217 2017年3月査読有り
Impact of hyperpolarization-activated Cl- current on arrhythmogenecity of rat pulmonary vein cardiomyocytes

Okamoto Yosuke, Ono Kyoichi, Takano Makoto, Ishii Kuniaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S77 2016年3月査読有り
Intra-organellar Ca2+ Signaling Imaged Using Genetically Encoded Ca2+ Indicators CEPIA

Suzuki Junji, Kanemaru Kazunori, Ishii Kuniaki, Ohkura Masamichi, Okubo Yohei, Iino Masamitsu

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S252 2016年3月査読有り
Effects of high glucose on Kv 1.5 and Kir2.1 channels

Jimbu Ryota, Nagasawa Yoshinobu, Ishii Kuniaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S104 2016年3月査読有り
ERK5 regulates catecholamine biosynthesis and homeostasis in neural cells and human adrenal medullas

Obara Yutaro, Nagasawa Ryusuke, Nemoto Wataru, Pellegrino Michael, Takahashi Maho, Habecker Beth, Stork Philip, Ichiyanagi Osamu, Ito Hiromi, Tomita Yoshihiko …

JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S141 2015年7月査読有り
Azelnidipine reduces surface expression levels of Ca(v)1.2 channel

Nasu Fumiaki, Kurakami Kazuya, Ishii Kuniaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S150 2015年7月査読有り
Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

Suzuki Junji, Kanemaru Kazunori, Ishii Kuniaki, Ohkura Masamichi, Okubo Yohei, Iino Masamitsu

JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S179 2015年7月査読有り
KCNQ1 channel does not form a complex with alpha(1) adrenergic receptor when it is internalized by the receptor activation

Kazuya Kurakami, Ikuo Norota, Yoshinobu Nagasawa, Yutaro Obara, Kuniaki Ishii

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 195P-195P 2014年査読有り
Possible involvement of PIP2 in KCNQ1/KCNE1 current inhibition by insulin

Shingo Ohshima, Yoshinobu Nagasawa, Minghua Wu, Norota Ikuo, Kuniaki Ishii

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 106P-106P 2014年査読有り
Imaging of Ca2+ dynamics within the endoplasmic reticulum and mitochondria using new GFP-based fluorescent Ca2+ indicators

Junji Suzuki, Kazunori Kanemaru, Kuniaki Ishii, Masamichi Ohkura, Yohei Okubo, Masamitsu Iino

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 92P-92P 2014年査読有り
NGF activates ERK5 in Ras and Rap1-independent manners and promotes neurite outgrowth and catecholamine biosynthesis

Yutaro Obara, Philip Stork, Beth Habecker, Kuniaki Ishii, Norimichi Nakahata

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 66P-66P 2014年査読有り
On the mechanism by which receptor activation modulates I-Ks channel - involvement of PIP2 -

Kuniaki Ishii, Shingo Ohsima, Yoshinobu Nagasawa, Kazuya Kurakami, Ikuo Norota

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 59P-59P 2014年査読有り
G alpha h/TG2 enhances adenylylcyclase 8 activity in human and rat glioma cells

Yutaro Obara, Yoshimi Yanagihata, Tomohiro Abe, Laila Dafik, Kuniaki Ishii, Norimichi Nakahata

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 27P-27P 2014年査読有り
Imaging of Ca2+ dynamics within the endoplasmic reticulum using new fluorescent Ca2+ indicators

Junji Suzuki, Kazunori Kanemaru, Kuniaki Ishii, Masamichi Ohkura, Masamitsu Iino

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 191P-191P 2013年査読有り
Internalization of KCNQ1 channel by activation of the alpha(1A) and alpha(1B) adrenergic receptor

Kurakami Kazuya, Norota Ikuo, Wu Minghua, Obara Yutaro, Ishii Kuniaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 97P 2013年査読有り
Imaging of Ca2+ dynamics within the endoplasmic reticulum using a new fluorescent Ca2+ indicator

Junji Suzuki, Kazunori Kanemaru, Kuniaki Ishii, Masamichi Ohkura, Masamitsu Iino

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 209P-209P 2012年査読有り
KCNE1 is essential for inhibition of KCNQ1/KCNE1 currents by insulin

Minghua Wu, Ikuo Norota, Kazuya Kurakami, Kuniaki Ishii

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 89P-89P 2012年査読有り
Axonal ATP signaling mediates Schwann cell myelination

Daisuke Ino, Kazunori Kanemaru, Yohei Okubo, Kuniaki Ishii, Masamichi Ohkura, Masamitsu Iino

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 73P-73P 2012年査読有り
Bidirectional roles of brain 2-arachidonoylglycerol in bombesin-induced activation of central sympatho-adrenomedullary outflow in rats

Daisuke Ino, Kazunori Kanemaru, Yohei Okubo, Kuniaki Ishii, Masamichi Ohkura, Masamitsu Iino

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 73P-73P 2012年査読有り
Augmentation of KCNQ1/KCNE1 currents by insulin treatment

Minghua Wu, Ikuo Norota, Kuniaki Ishii

JOURNAL OF PHARMACOLOGICAL SCIENCES 115 262P-262P 2011年査読有り

もっとみる

書籍等出版物

Permeation of voltage-dependent pottossium channels

Potossium ion channels ; Their molecular structure, function and diseases. ed. by Y. Kurachi et al. Academic Press 1999年
Chapter 4 Permeation of Voltage-Dependent Potassuim Channels

(担当:分担執筆)

Current Topics in Membranes and Transport 1999年

石井邦明

基本情報

研究キーワード

研究分野

学歴

論文

経歴

MISC

書籍等出版物

担当経験のある科目(授業)

所属学協会

メニュー