2000年6月
Interaction between norepinephrine release and intrarenal angiotensin II formation during renal nerve stimulation in dogs
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
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- 巻
- 35
- 号
- 6
- 開始ページ
- 831
- 終了ページ
- 837
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1097/00005344-200006000-00001
- 出版者・発行元
- LIPPINCOTT WILLIAMS & WILKINS
We examined possible interactions between intrarenal angiotensin II (ANG II) formation and norepinephrine (NE) release during renal sympathetic nerve stimulation (RNS) in anesthetized dogs. During 10 min of continuous RNS (1.5-2 Hz), the ANG II formation rates (ANG II-FR) and NE secretion rates (NE-SR) were determined at 1 and 10 min. Under control conditions, almost the same extent of increase in the NE-SR was observed at 1 and 10 min of RNS, whereas a significant increase in ANG TI-FR was observed at 10 min but not at 1 min. During intrarenal arterial infusion of enalaprilat or losartan, the increase in NE-SR and reduction in renal blood flow at 10 min of RNS were suppressed, whereas the NE release and vasoconstriction responses at 1 min remained unaffected. The RNS-induced increases in ANG II-FR were completely abolished during infusion of enalaprilat. These results suggest that NE release on continuous RNS is enhanced by concomitantly formed ANG II, and this interaction depends on the time-related changes in intrarenal ANG II formation during RNS in the canine kidney.
- リンク情報
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- DOI
- https://doi.org/10.1097/00005344-200006000-00001
- CiNii Articles
- http://ci.nii.ac.jp/naid/80011760373
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10836714
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000087135600001&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1097/00005344-200006000-00001
- ISSN : 0160-2446
- CiNii Articles ID : 80011760373
- PubMed ID : 10836714
- Web of Science ID : WOS:000087135600001