関政幸 (Masayuki Seki) - マイポータル

基本情報

学位: 薬学博士(東京大学)

J-GLOBAL ID: 200901037570288457
researchmap会員ID: 1000183965

外部リンク: http://db.tohoku.ac.jp/whois/detail/b074a71bf612ce8ce9c7cd88f1529112.html

研究キーワード

研究分野

経歴

2000年 - 2002年

東北大学大学院薬学研究科講師
2002年

- 東北大学大学院薬学研究科助教授
1995年 - 2000年

東北大学大学院薬学研究科助手
1992年 - 1995年

英国オックスフォード大学ヒューマンフロンティア・ポストドクター
1990年 - 1992年

東京大学大学院薬学系研究科および理化学研究所（和光）日本学術振興会がん特別研究員
1989年 - 1990年

東京大学薬学系研究科日本学術振興会特別研究員
東北大学大学院薬学研究科生命薬科学専攻生命情報薬学講座遺伝子制御薬学分野, 准教授

学歴

論文

WRNIP1 Controls the Amount of PrimPol.

Akari Yoshimura, Mizuho Oikawa, Hitomi Jinbo, Yuri Hasegawa, Takemi Enomoto, Masayuki Seki

Biological & pharmaceutical bulletin 42(5) 764-769 2019年査読有り
The role of WRNIP1 in genome maintenance

Akari Yoshimura, Masayuki Seki, Takemi Enomoto

CELL CYCLE 16(6) 515-521 2017年査読有り
Simultaneous depletion of WRNIP1 and RAD52 restores resistance to oxidative stress

Yoshimura Akari, Yabe Haruna, Akatani Miho, Seki Masayuki, Enomoto Takemi

Fundamental Toxicological Sciences (Web) 4(1) 1‐7(J‐STAGE)-7 2017年
Excess Cdt1 inhibits nascent strand elongation by repressing the progression of replication forks in Xenopus egg extracts

Yuta Nakazaki, Takashi Tsuyama, Masayuki Seki, Mikiko Takahashi, Takemi Enomoto, Shusuke Tada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 470(2) 405-410 2016年2月査読有り
WRNIP1 functions upstream of DNA polymerase η in the UV-induced DNA damage response.

Yoshimura A, Kobayashi Y, Tada S, Seki M, Enomoto T

Biochemical and biophysical research communications 452(1) 48-52 2014年9月査読有り
Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells

Yuki Tamari, Hisakatsu Nawata, Eri Inoue, Akari Yoshimura, Hanako Yoshii, Genro Kashino, Masayuki Seki, Takemi Enomoto, Masami Watanabe, Keizo Tano

FREE RADICAL RESEARCH 47(1) 1-7 2013年1月査読有り
WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain

Hironoshin Nomura, Akari Yoshimura, Takato Edo, Shin-ichiro Kanno, Syusuke Tada, Masayuki Seki, Akira Yasui, Takemi Enomoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 417(4) 1145-1150 2012年1月査読有り
Functional relationship between Claspin and Rad17

Akari Yoshimura, Motomu Akita, Yoshifumi Hosono, Takuya Abe, Masahiko Kobayashi, Ken-ichi Yamamoto, Shusuke Tada, Masayuki Seki, Takemi Enomoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 414(2) 298-303 2011年10月査読有り
Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication

Katsuyuki Ishikawa, Tatsuya Ohsumi, Shusuke Tada, Ryo Natsume, Lena Rani Kundu, Naohito Nozaki, Toshiya Senda, Takemi Enomoto, Masami Horikoshi, Masayuki Seki

GENES TO CELLS 16(10) 1050-1062 2011年10月査読有り
The Histone Chaperone Facilitates Chromatin Transcription (FACT) Protein Maintains Normal Replication Fork Rates

Takuya Abe, Kazuto Sugimura, Yoshifumi Hosono, Yasunari Takami, Motomu Akita, Akari Yoshimura, Shusuke Tada, Tatsuo Nakayama, Hiromu Murofushi, Katsuzumi Okumura …

JOURNAL OF BIOLOGICAL CHEMISTRY 286(35) 30504-30512 2011年9月査読有り
Werner Interacting Protein 1 Promotes Binding of Werner Protein to Template-Primer DNA

Makoto Kanamori, Masayuki Seki, Akari Yoshimura, Toshiki Tsurimoto, Shusuke Tada, Takemi Enomoto

BIOLOGICAL & PHARMACEUTICAL BULLETIN 34(8) 1314-1318 2011年8月査読有り
Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

Mayumi Ohkawa, Yoshiya Ohno, Kazue Masuko, Akiko Takeuchi, Kentaro Suda, Akihiro Kubo, Rieko Kawahara, Shogo Okazaki, Toshiyuki Tanaka, Hideyuki Saya …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 406(4) 649-655 2011年3月査読有り
Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex

Lena R. Kundu, Yuji Kumata, Naoko Kakusho, Saori Watanabe, Asako Furukohri, Shou Waga, Masayuki Seki, Hisao Masai, Takemi Enomoto, Shusuke Tada

NUCLEIC ACIDS RESEARCH 38(16) 5409-5418 2010年9月査読有り
Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication

Takashi Ohuchi, Masayuki Seki, Kazuto Kugou, Shusuke Tada, Kunihiro Ohta, Takemi Enomoto

DNA REPAIR 8(6) 690-696 2009年6月査読有り
Physical and functional interaction between WRNIP1 and RAD18

Akari Yoshimura, Masayuki Seki, Makoto Kanamori, Satoshi Tateishi, Toshiki Tsurimoto, Shusuke Tada, Takemi Enomoto

GENES & GENETIC SYSTEMS 84(2) 171-178 2009年4月査読有り
KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation

Takuya Abe, Masamichi Ishiai, Yoshifumi Hosono, Akari Yoshimura, Shusuke Tada, Noritaka Adachi, Hideki Koyama, Minoru Takata, Shunichi Takeda, Takemi Enomoto …

CELLULAR SIGNALLING 20(11) 1978-1985 2008年11月査読有り
A novel role for Rad17 in homologous recombination

Katsuaki Nishino, Eri Inoue, Shunya Takada, Takuya Abe, Motomu Akita, Akari Yoshimura, Shusuke Tada, Masahiko Kobayashi, Ken-ichi Yamamoto, Masayuki Seki …

GENES & GENETIC SYSTEMS 83(5) 427-431 2008年10月査読有り
Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIalpha.

Makoto Otsuki, Masayuki Seki, Eri Inoue, Takuya Abe, Yoshiyasu Narita, Akari Yoshimura, Shusuke Tada, Yutaka Ishii, Takemi Enomoto

Biochimica et biophysica acta 1782(2) 75-81 2008年2月
Functional interactions between BLM and XRCC3 in the cell

Makoto Otsuki, Masayuki Seki, Eri Inoue, Akari Yoshimura, Genta Kato, Saki Yamanouchi, Yoh-ichi Kawabe, Shusuke Tada, Akira Shinohara, Jun-ichiro Komura …

JOURNAL OF CELL BIOLOGY 179(1) 53-63 2007年10月査読有り
Vertebrate POLQ and POL beta cooperate in base excision repair of oxidative DNA damage

Michio Yoshimura, Masaoki Kohzaki, Jun Nakamura, Kenjiro Asagoshi, Eiichiro Sonoda, Esther Hou, Rajendra Prasad, Samuel H. Wilson, Keizo Tano, Akira Yasui …

MOLECULAR CELL 24(1) 115-125 2006年10月査読有り

MISC

134

RecQ ヘリカーゼとゲノム安定性維持機構

関政幸

東北薬科大学研究誌 60 1-11 2013年12月
Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2

Hirohito Endo, Yu Nakabayashi, Satoshi Kawashima, Takemi Enomoto, Masayuki Seki, Masami Horikoshi

GENES TO CELLS 17(1) 65-81 2012年1月
Embryonic Lethality in Mice Lacking Mismatch-Specific Thymine DNA Glycosylase Is Partially Prevented by DOPS, a Precursor of Noradrenaline

Yusuke Saito, Tetsuya Ono, Naoki Takeda, Takehiko Nohmi, Masayuki Seki, Takemi Enomoto, Tetsuo Noda, Yoshihiko Uehara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 226(1) 75-83 2012年1月
“RecQLS ヘリガーゼのDNA クロスリンク修復における役割”

細野嘉史, 関政幸, 阿部拓也, 石合正道, 武田俊一, 石井裕, 高田穣, 榎本武美

第35回日本分子生物学会年会 2012年12月 2012年査読有り
Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation

Satoshi Kawashima, Yu Nakabayashi, Kazuko Matsubara, Norihiko Sano, Takemi Enomoto, Kozo Tanaka, Masayuki Seki, Masami Horikoshi

EMBO JOURNAL 30(16) 3353-3367 2011年8月
The role of SNM1 family nucleases in etoposide-induced apoptosis

Yoshifumi Hosono, Takuya Abe, Masamichi Ishiai, Minoru Takata, Takemi Enomoto, Masayuki Seki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 410(3) 568-573 2011年7月
Biphasic chromatin binding of FACT during DNA replication.

Kundu, L. R, Seki, M, Watanabe, N, Murofusi H, Furukohri, A, Waga, S, Score A. J, Blow, J. J, Horikoshi, M, nomoto, T …

Biochim. Biophys. Acta 8313(6) 1129-1136 2011年6月
The N-terminal region of RECQL4 lacking the helicase domain is both essential and sufficient for the viability of vertebrate cells Role of the N-terminal region of RECQL4 in cells

Takuya Abe, Akari Yoshimura, Yoshifumi Hosono, Shusuke Tada, Masayuki Seki, Takemi Enomoto

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1813(3) 473-479 2011年3月
Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination

Hirohito Endo, Satoshi Kawashima, Lui Sato, Mong Sing Lai, Takemi Enomoto, Masayuki Seki, Masami Horikoshi

GENES TO CELLS 15(9) 945-958 2010年9月
「DNA ヘリカーゼRECQL5 のDNA 組換え・修復における機能の解析」

細野嘉史, 阿部卓也, 石合正道, 多田周右, 武田俊一, 高田穣, 関政幸, 榎本武美

第33 回日本分子生物学会年会 2010 年12 月 2010年査読有り
Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants

Makoto Sakamoto, Shuhei Noguchi, Satoshi Kawashima, Yusuke Okada, Takemi Enomoto, Masayuki Seki, Masami Horikoshi

GENES TO CELLS 14(11) 1271-1330 2009年11月
Repression of Nascent Strand Elongation by Deregulated Cdt1 during DNA Replication in Xenopus Egg Extracts

Takashi Tsuyama, Saori Watanabe, Ayako Aoki, Yunje Cho, Masayuki Seki, Takemi Enomoto, Shusuke Tada

MOLECULAR BIOLOGY OF THE CELL 20(3) 937-947 2009年2月
Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2

Shunya Takada, Eri Inoue, Keizo Tano, Hanako Yoshii, Takuya Abe, Akari Yoshimura, Motomu Akita, Shusuke Tada, Masami Watanabe, Masayuki Seki …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379(2) 233-238 2009年2月
Nuclear localization of Rad52 is pre-requisite for its sumoylation

Takashi Ohuchi, Masayuki Seki, Takemi Enomoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 372(1) 126-130 2008年7月
Rad52 sumoylation and its involvement in the efficient induction of homologous recombination

Takashi Ohuchi, Masayuki Seki, Dana Branzei, Daisuke Maeda, Ayako Ui, Hideaki Ogiwara, Shusuke Tada, Takemi Enomoto

DNA REPAIR 7(6) 879-889 2008年6月
Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase III α.

Otsuki, M, Seki, M, Inoue, E, Abe. T, Narita, Y, Yoshimura, A, Tada, S, Ishii, Y, nomoto, T

Biochim. Biophys. Acta 1782(2) 75-81 2008年2月
Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability

Tomoko Hayashi, Masayuki Seki, Eri Inoue, Akari Yoshimura, Yumiko Kusa, Shusuke Tada, Takemi Enomoto

Genes and Genetic Systems 83(1) 95-100 2008年
Ctf18 is required for homologous recombination-mediated double-strand break repair

Hideaki Ogiwara, Takashi Ohuchi, Ayako Ui, Shusuke Tada, Takemi Enomoto, Masayuki Seki

NUCLEIC ACIDS RESEARCH 35(15) 4989-5000 2007年8月
Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion

Mong Sing Lai, Masayuki Seki, Ayako Ui, Takemi Enomoto

EMBO REPORTS 8(7) 685-690 2007年7月
The INO80 chromatin remodeling complex functions in sister chromatid cohesion

Hideaki Ogiwara, Takemi Enomoto, Masayuki Seki

CELL CYCLE 6(9) 1090-1095 2007年5月