TSUKUBA Takayuki

J-GLOBAL         Last updated: Oct 12, 2018 at 13:36
 
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Name
TSUKUBA Takayuki
Affiliation
Nagasaki University
Section
Graduate School of Biomedical Sciences, Medical and Dental Sciences
Job title
Professor
ORCID ID
http://orcid.org/0000-0003-3322-1339

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
2007
   
 
 Professor,Medical and Dental Sciences,Medical and Dental Sciences,Graduate School of Biomedical Sciences,Nagasaki University
 
1994
 - 
2000
 Research Associate
 
1997
 - 
1999
 Researcher
 
2000
 - 
2007
 Associate Professor
 

Education

 
 
 - 
1994
Graduate School, Division of Dental Research, Kyushu University
 
 
 - 
1990
Faculty of Dentistry, Nagasaki University
 

Published Papers

 
Rutaecarpine attenuates osteoclastogenesis by impairing macrophage colony stimulating factor and receptor activator of nuclear factor κ-B ligand-stimulated signalling pathways.
Fukuma Y, Sakai E, Komaki S, Nishishita K, Okamoto K, Tsukuba T.
Clin Exp Pharmacol Physiol.   45(8) 863-865   Aug 2018   [Refereed]
Transcription factor EB influences invasion and migration in oral squamous cell carcinomas.
Sakamoto H, Yamashita K, Okamoto K, Kadowaki T, Sakai E, Umeda M, Tsukuba T.
24(5) 741-748   Jul 2018   [Refereed]
Takii R, Kadowaki T, Tsukuba T, Yamamoto K.
Eur J Pharmacol.   824 48-56   Apr 2018   [Refereed]
Dihydroartemisinin represses osteoclastogenesis of bone marrow macrophages through reduced NFATc1 expression and impaired phosphorylation of IκBα.
Komaki S, Sakai E, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T.
Biomed Res.   39(4) 169-177   2018   [Refereed]
Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion.
Narahara H, Sakai E, Yamaguchi Y, Narahara S, Iwatake M, Okamoto K, Yoshida N, Tsukuba T.
J Cell Physiol.      2018   [Refereed]
Rab44, a novel large Rab GTPase, negatively regulates osteoclast differentiation by modulating intracellular calcium levels followed by NFATc1 activation.
Yamaguchi Y, Sakai E, Okamoto K, Kajiya H, Okabe K, Naito M, Kadowaki T, Tsukuba T.
Cell Mol Life Sci.   75(1) 33-48   Jan 2018   [Refereed]
The dental resin monomers HEMA and TEGDMA have inhibitory effects on osteoclast differentiation with low cytotoxicity.
Inamitsu H, Okamoto K, Sakai E, Nishishita K, Murata H, Tsukuba T.
J Appl Toxicol.   37(7) 817-824   Jul 2017   [Refereed]
Yamashita K, Iwatake M, Okamoto K, Yamada SI, Umeda M, Tsukuba T
Oral Dis.   23 518-525   May 2017   [Refereed]
Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.
Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T.
FASEB J.   31(9) 4011-4022   2017   [Refereed]
Zaitsu Y, Iwatake M, Sato K, Tsukuba T.
Microbes Infect.   18(9) 565-571   Sep 2016   [Refereed]
Klionsky DJ, Abdelmohsen K,--- Tsukuba T et al.
Autophagy.   12 1-222   Jan 2016   [Refereed]
Yoneshima E, Okamoto K, Sakai E, Nishishita K, Yoshida N, Tsukuba T
J Cell Physiol.   231 1321-1333   2016   [Refereed]
Uchino K, Okamoto K, Sakai E, Yoneshima E, Iwatake M, Fukuma Y, Nishishita K, Tsukuba T.
Phytother Res.   29(11) 1714-1721   Nov 2015   [Refereed]
Yashima Y, Okamoto K, Sakai E, Iwatake M, Fukuma Y, Nishishita K, Tsukuba T.
Biometals.   28(4) 725-732   Aug 2015   [Refereed]
Iwatake M, Okamoto K, Tanaka T, Tsukuba T.
Mol Cell Biochem   28 725-732   Aug 2015   [Refereed]
Fukuma Y, Sakai E, Nishishita K, Okamoto K, Tsukuba T.
Biofactors.   41(4) 222-231   Jul 2015   [Refereed]
Iwatake M, Okamoto K, Tanaka T, Tsukuba T.
Phytother Res.   29(6) 917-924   Jun 2015   [Refereed]
Shimada-Sugawara M, Sakai E, Okamoto K, Fukuda M, Izumi T, Yoshida N, Tsukuba T.
Sci Rep.   5 9620   2015   [Refereed]

Misc

 
Isolation and characterization of recombinant human cathepsin E expressed in Chinese hamster ovary cells.
Tsukuba T, Hori H, Azuma T, Takahashi T, Taggart RT, Akamine A, Ezaki M, Nakanishi H, Sakai H, Yamamoto K.
268(10) 7276-7282   1993

Research Grants & Projects

 
Proteolysis by Endosome Lysosome System
Basic Science Research Program
Project Year: 1991   
new functions of endosome/lysosome system
Cooperative Research
Project Year: 1991