TSUZUKI Teruhisa

J-GLOBAL         Last updated: Feb 28, 2019 at 18:19
 
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Name
TSUZUKI Teruhisa
URL
http://www.med.kyushu-u.ac.jp/biophys/
Affiliation
Kyushu University
Job title
Professor
Degree
Doctor of Science(Kyushu University), Master of Science(Kyushu University)

Research Areas

 
 

Academic & Professional Experience

 
1982
 - 
1990
Kumamoto University Medical School, Research Associate
 
1988
 - 
1992
Howard Hughes Medical Institute, University of Utah,(USA)Research Associate
 
1992
 - 
1998
Medical Institute of Bioregulation, Kyushu University, Associate Professor
 
1998
 - 
2000
Faculty of Medicine, Kyushu University, Professor
 
2000
   
 
- Faculty of Medical Sciences, Kyushu University, Professor
 

Education

 
 
 - 
1981
Graduate School of Science, Biology(Molecular Genetics), Kyushu University
 
 
 - 
1975
Faculty of Science, Kyushu University
 

Awards & Honors

 
Nov 2017
JEMS Award, The Japanese Environmental Mutagen Society
 
May 2014
Prevention of Oxidative Tumorigenesis by DNA Repair Enzymes: Implication in Human Cancer, AARR Award (Medicine), Asian Association for Radiation Research
 

Published Papers

 
Takuro Isoda, Yoshimichi Nakatsu, Kazumi Yamauchi, Jingshu Piao, Takashi Yao, Hiroshi Honda, Yusaku Nakabeppu, Teruhisa Tsuzuki
International Journal of Biological Sciences   10(8) 940-947   Aug 2014   [Refereed]
Mizuki Ohno, Kunihiko Sakumi, Ryutaro Fukumura, Masato Furuichi, Yuki Iwasaki, Masaaki Hokama, Toshimichi Ikemura, Teruhisa Tsuzuki, Yoichi Gondo, Yusaku Nakabeppu
Scientific Reports      Apr 2014   [Refereed]
Jingshu Piao, Yoshimichi Nakatsu, Mizuki Ohno, Ken-ichi Taguchi, Teruhisa Tsuzuki
International Journal of Biological Sciences   10(1) 73-79   Jan 2014   [Refereed]
Teik-How Lim, Ryosuke Fujikane, Shiori Sano, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, and Masumi Hidaka
DNA Repair   11 259-266   Jan 2012   [Refereed]
Sanada M, Hidaka M, Takagi Y, Takano TY, Nakatsu Y, Tsuzuki T, Sekiguchi M.
Carcinogenesis   28(12) 2657-2663   Dec 2007   [Refereed]
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption
Sakumi, K., Tominaga, Y., Furuichi, M., Xu, P. Tsuzuki, T., Sekiguchi, M. and Nakabeppu, Y.
Cancer Res.   63(5) 902-905   Mar 2003   [Refereed]
Egashira, A., Yamauchi, K., Yoshiyama, K., Kawate, H., Katsuki, M., Sekiguchi, M., Sugimachi, K., Maki, H. and Tsuzuki, T.
DNA Rerair   1(11) 881-893   Oct 2002   [Refereed]
Tsuzuki, T., Egashira, A., Igarashi, H., Iwakuma, T., Nakatsuru, Y., Tominaga, Y., Kawate, H., Nakao, K., Nakamura, K., ide, F., Kura, S., Nakabeppu, Y., Katsuki, M., Ishikawa, T. and Sekiguchi, M.
Proc. Natl. Acad. Sci. USA   98(20) 11456-11461   Sep 2001   [Refereed]
Tsuzuki, T. and Rancourt, D. E.
Nucl. Acids Res.   26(4) 988-993   Jan 1998   [Refereed]
Igarashi, H., Tsuzuki, T., Kakuma, T., Tominaga, Y. and Sekiguchi, M.
J. Biol. Chem.   272(6) 3766-3772   Feb 1997   [Refereed]
Tsuzuki, T., Fujii, Y., Sakumi, K., Tominaga, Y., Nakao, K., Sekiguchi, M., Matsushiro, A., Yoshimura, Y. and Morita, T.
Proc. Natl. Acad. Sci. USA   93(13) 6236-6240   Jun 1996   [Refereed]
Tsuzuki, T., Sakumi, K., Shiraishi, A., Kawate, H., Igarashi, H., Iwakuma, T., Tominaga, Y., Zhang, S., Shimizu, S., Ishikawa, T., Nakamura, K., Nakao, K., Katsuki, M. and Sekiguchi, M.
Carcinogenesis   17(6) 1215-1220   Jun 1996   [Refereed]

Misc

 
Teik-How Lim, Ryosuke Fujikane, Shiori Sano, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, and Masumi Hidaka
DNA Repair   11(3) 259-266   Jan 2012   [Refereed]
Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice.
Tsuzuki, T., Piao, J., Isoda, T., Sakumi, K., Nakabeppu, Y., Nakatsu, Y.
Health Physics   100(3) 293-294   Mar 2011   [Refereed]
Komori, K., Takagi, Y., Sanada, M., Lim, T.-H., Nakatsu, Y., Tsuzuki, T., Sekiguchi, M., and Hidaka, M.
Oncogene   28 1142-1150   Jan 2009   [Refereed]
Sanada M, Hidaka M, Takagi Y, Takano TY, Nakatsu Y, Tsuzuki T, Sekiguchi M.
Carcinogenesis   28(12) 2657-2663   Dec 2007   [Refereed]
Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., Maki, H., Nakabeppu, Y. and Tsuzuki, T.
Cancer Res.   67(14) 6599-6604   Jul 2007
A new locus of ┣DBEscherichia coli(/)-┫DB that determines sensitivity to bacteriophage 'jointly worked'
J. Bacteriol.   138(3) 1038-1040   1979
Lambda bacteriophage-mediated transduction of ColE1 deoxyribonucleic acid having a lambda bacteriophage-cohesive end site : Selection of packageable-length deoxyribonucleic acid. 'jointly worked'
J. Bacteriol.   139(3) 738-747   1979
Presence of mitochondrial-DNA-like sequences in the human nuclear DNA. 'jointly worked'
Gene   25(2-3) 223-229   1983
Structure of the human prealbumin gene. 'jointly worked'
J. Biol. Chem.   260(22) 12224-12227   1985
Familial amyloidotic polyneuropathy diagnosed by cloned human prealbumin cDNA. 'jointly worked'
Neurology   36(2) 298-301   1986
Isolation and characterization of the human ornithine transcarbamylase gene : Structure of the 5' -end region. 'jointly worked'
J. Biochem.   100(3) 717-725   1986
Cloning and sequence analysis of cDNAs encoding mammalian cytosolic malate dehydrogenase : amino acid sequences of mammalian and bacterial malate dehydrogenase. 'jointly worked'
J. Biol. Chem.   262(31) 15127-15131   1987
Structure of the human ornithine transcarbamylase gene.
J. Biochem.   103(2) 302-308   1988
Structural organization of the human ornithine trans carbamylase gene. 'jointly worked'
J. Inherit. Metab. Dis.   11(337-340)    1988
Structure of the ornithine transcarbamylase (OTC) gene and DNA diagnosis of OTC deficiency. 'jointly worked'
Clin. Chim. Acta   185(3) 283-290   1989
Regulatory regions of the mitochondrial and cytosolic isoenzyme genes participating in the malate-aspartate shuttle. 'jointly worked'
J. Biol. Chem.   265(3) 1293-1299   1990
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. 'jointly worked'
J. Biol. Chem.   268(31) 23524-23530   1993
DNA-repair methyltransferase as a molecular device for preventing mutation and cancer. 'jointly worked'
J. Cancer Res. Clin. Oncol.   122(4) 199-206   1996
Methylnitrosourea-induced tumorigenesis in MGMT gene-knockout mice. 'jointly worked'
Cancer Res.   67 2415-2418   1997
Presence of Potential Nickel-Responsive Element(s)in the Mouse ┣DBMTHI(/)-┫DB Promoter. 'jointly worked'
Annals of Clinical & Laboratory Science   31(1) 91-98   2001
Proc. Natl. Acad. Sci. USA   98(20) 11456-11461   2001

Books etc

 
Oxidative DNA damege-induced intestinal tumorigenesis
TSUZUKI Teruhisa, OHNO Mizuki, NAKATSU, Yoshimichi (Part:Joint Work)
Apr 2015   
The genes involved in the repair of alkylated DNA in ┣DBEscherichia coli(/)-┫DB K-12. 'jointly worked'
Cellular responses to DNA damage Alan R. Liss   1983   
Molecular pathogenesis of familial amyloidotic polyneuropathy. 'jointly worked'
Molecular Genetics in Developmental Neurology. Japan Scientific Societies Press   1986   
Spontaneous tumorigenesis and mutagenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
International Congress Series   2002   

Conference Activities & Talks

 
Oxidative stress-induced intestinal tumors in Mutyh-deficient mice treated with low doses of potassium bromate.
TSUZUKI Teruhisa
4th Asian Conference on Environmental Mutagen   10 Dec 2014   
Oxidative stress-induced intestinal tumors in Mutyh-deficient mice treated with low doses of potassium bromate.
TSUZUKI Teruhisa
5th US-Japan DNA Repair Meeting   29 Oct 2014   
Current Issues of Radiation Risk Education in Japanese Universtities, especially Medical Schools
TSUZUKI Teruhisa
FMU-IAEA International Academic Conference, Radiation, Health, and Society: Post-Fukushima Implications for Health Professional Education   23 Nov 2013   
Oxidative stress-induced tumorigenesis in the small intestines of Mutyh-deficient mice: the effect of low-level exposure to KBrO3
TSUZUKI Teruhisa
11th International Conference on Environmental Mutagens   6 Nov 2013   
Oxidative stress-induced tumorigenesis in the small intestine of Mutyh-deficient mice: the effect of low-level exposure to KBrO3
TSUZUKI Teruhisa
5 Oct 2013   
Prevention of Oxidative Tumorigenesis by DNA Repair Enzymes: Implication in Human Cancer
TSUZUKI Teruhisa
The 3rd Asian Congress of Radiation Research (ACRR 2013)   13 May 2013   
Prevention of Oxidative Mutagenesis by DNA Repair Enzymes: Implication in Human Cancer
TSUZUKI Teruhisa
2nd Asian Conference on Environmental Mutagens: Harmonize Gene & Environment   Dec 2010   
Oxidative stress-induced tumorigenesis in the small intestine of various types of DNA repair-deficient mice
TSUZUKI Teruhisa
10th International Conference on Environmental Mutagens (ICEM)   Aug 2009   
Plenary Lecture: Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis
9th European Biological Inorganic Chemistry Conference   2008   

Works

 
Radiation Induced DNA Damage and Its Defence Mechanism
1999
Exploiting Bacteriophage Genetics for High Throughput Functional Genomics
1996

Research Grants & Projects

 
Molecular Mechanism for Maintenance of Genetic Information
Grant-in-Aid for Scientific Research
Project Year: 1992   
Oxygen-induced DNA Damage and Its Repair Mechanisms
Grant-in-Aid for Scientific Research
Project Year: 1992   
Development of an Efficient System for Gene Targeting
Grant-in-Aid for Scientific Research
Project Year: 1990   
Radiation Induced DNA Damage and Its Defense Mechanism
Grant-in-Aid for Promotion of Private Scientific Research
Project Year: 1999   
Exploiting Bacteriophage Genetics for High Throughput Functional Genomics
Radiation Induced DNA Damage and Its Defense Mechanism
Grant-in-Aid for Promotion of Private Scientific Research
Project Year: 1999   
Radiation Induced DNA Damage and Its Defence Mechanism
Project Year: 2001 - 2003

Patents

 
Bacteriophage Vectors Generated by Bacteriophage/Plasmid Recombination
US 6,335,185