論文

査読有り 筆頭著者 責任著者 本文へのリンクあり
2007年12月

カルニチンの代謝および中枢神経系への作用-カルニチン欠損マウスを用いて-

ビタミン
  • 吉田剛一郎
  • ,
  • 堀内正久
  • ,
  • 小林圭子
  • ,
  • 佐伯武頼

81
12
開始ページ
601
終了ページ
610
記述言語
日本語
掲載種別
研究論文(学術雑誌)
DOI
10.20632/vso.81.12_601
出版者・発行元
公益社団法人 日本ビタミン学会

In this review, we summarize our recent reports: the roles of carnitine in the general metabolism and the central nervous system, and the effects of carnitine administration to the fasted carnitine-deficient juvenile visceral steatosis (JVS) mice. Fasting reduced locomotor activity (LA) of JVS mice. Single carnitine administration caused an increase of the reduced LA and the fat expenditure, and the effects were prolonged for at least two days after the administration, although the carnitine concentration in blood and tissues returned to the original carnitine-deficient level. In JVS mice, fasting also caused a decreased percentage of c-Fos positive orexin neurons in the lateral hypothalamus (ameliorated by carnitine administration) and a reduced orexin-A concentration in the cerebrospinal fluid. These results suggest that the low tissue carnitine level of JVS mice is not the sole rate-limiting factor of general fatty acid oxidation, and the reduced LA in fasted JVS mice is related to the inhibition of orexin neuronal activity.

リンク情報
DOI
https://doi.org/10.20632/vso.81.12_601 本文へのリンクあり
CiNii Articles
http://ci.nii.ac.jp/naid/110006532819
CiNii Books
http://ci.nii.ac.jp/ncid/AN00207833
URL
http://id.ndl.go.jp/bib/9314616
URL
http://search.jamas.or.jp/link/ui/2008133378
ID情報
  • DOI : 10.20632/vso.81.12_601
  • ISSN : 0006-386X
  • CiNii Articles ID : 110006532819
  • CiNii Books ID : AN00207833

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