Kentaro Semba

Profile Information

Affiliation: Professor, Faculty of Science and Engineering School of Advanced Science and Engineering, Waseda University

Degree: 理学博士

Researcher number: 70206663
J-GLOBAL ID: 200901036690543268
researchmap Member ID: 1000185075

Research Interests

Research Areas

Awards

1988

日本癌学会奨励賞

Major Papers

107

Metastatic potentials classified with hypoxia-inducible factor 1 downstream genes in pan-cancer cell lines.

Kazuya Nakamichi, Yusuke Yamamoto, Kentaro Semba, Jun Nakayama

Genes to cells : devoted to molecular & cellular mechanisms, Dec 29, 2023
Tyrosine Kinase Inhibitor Profiling Using Multiple Forskolin-Responsive Reporter Cells.

Yamato Kasahara, Sakura Tamamura, Gen Hiyama, Motoki Takagi, Kazuya Nakamichi, Yuta Doi, Kentaro Semba, Shinya Watanabe, Kosuke Ishikawa

International journal of molecular sciences, 24(18), Sep 8, 2023
Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis.

Yuxuan Han, Shota Katayama, Mitsuru Futakuchi, Kazuya Nakamichi, Yutaro Wakabayashi, Mai Sakamoto, Jun Nakayama, Kentaro Semba

Molecular cancer research : MCR, 21(9) 908-921, Sep 1, 2023 Peer-reviewedLast authorCorresponding author
Effect of lonidamine derivatives on the inhibition of transformed cell area expansion.

Megumi Aoyama, Taiki Homma, Ryohto Koharazawa, Yoshitomo Suhara, Kentaro Semba

Biochemistry and biophysics reports, 34 101480-101480, Jul, 2023 Peer-reviewedLast authorCorresponding author
HOXB7 induces STAT3‐mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

Kazushi Azuma, Mai Sakamoto, Shota Katayama, Atsuka Matsui, Kazuya Nakamichi, Naoki Goshima, Shinya Watanabe, Jun Nakayama, Kentaro Semba

Genes to Cells, 28(4) 277-287, Jan 27, 2023 Peer-reviewed
Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding nontransformed cells.

Megumi Aoyama, Kosuke Ishikawa, Shuntaro Nemoto, Hiroyuki Hirano, Nobumoto Watanabe, Hiroyuki Osada, Shinya Watanabe, Kentaro Semba

The Journal of biological chemistry, 298(12) 102635-102635, Dec, 2022 Peer-reviewedLast authorCorresponding author
Prediction of Resistance Mutations Against Upcoming Anaplastic Lymphoma Kinase Inhibitors.

Yuta Doi, Hiroaki Tagaya, Ayaka Noge, Kentaro Semba

Targeted oncology, 17(6) 695-707, Nov, 2022 Peer-reviewedLast authorCorresponding author
Isolation of Reporter Cells That Respond to Vitamin A and/or D Using a piggyBac Transposon Promoter-Trapping Vector System.

Kosuke Ishikawa, Sakura Tamamura, Nobuhito Takahashi, Motoki Takagi, Kentaro Semba, Shinya Watanabe

International journal of molecular sciences, 23(16), Aug 19, 2022 Peer-reviewed
Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models.

Yuxuan Han, Kazushi Azuma, Shinya Watanabe, Kentaro Semba, Jun Nakayama

Clinical & experimental metastasis, 39(3) 467-477, Feb 1, 2022 Peer-reviewed
Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

Jun Nakayama, Hiroko Matsunaga, Koji Arikawa, Takuya Yoda, Masahito Hosokawa, Haruko Takeyama, Yusuke Yamamoto, Kentaro Semba

Disease models & mechanisms, 15(6), Oct 21, 2021 Peer-reviewedLast authorCorresponding author
Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto, Kentaro Semba

Cancer cell international, 23(1) 57-57, Aug 28, 2021 Peer-reviewedLast authorCorresponding author
Establishment of reporter cells that respond to glucocorticoids by a transposon-mediated promoter-trapping system.

Kosuke Ishikawa, Sakura Tamamura, Kentaro Semba, Shinya Watanabe

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 162 105819-105819, Jul 1, 2021 Peer-reviewed
The In Vivo Selection Method in Breast Cancer Metastasis.

Jun Nakayama, Yuxuan Han, Yuka Kuroiwa, Kazushi Azuma, Yusuke Yamamoto, Kentaro Semba

International journal of molecular sciences, 22(4), Feb 14, 2021 Last author
A screening system for identifying interacting proteins using biomolecular fluorescence complementation and transposon gene trap.

Honami Miyakura, Mei Fukuda, Hiroya Enomoto, Kosuke Ishikawa, Shinya Watanabe, Kentaro Semba

PloS one, 16(5) e0251240, 2021 Peer-reviewedLast author
High Sensitivity In Vivo Imaging of Cancer Metastasis Using a Near-Infrared Luciferin Analogue seMpai.

Jun Nakayama, Ryohei Saito, Yusuke Hayashi, Nobuo Kitada, Shota Tamaki, Yuxuan Han, Kentaro Semba, Shojiro A Maki

International journal of molecular sciences, 21(21), Oct 24, 2020 Peer-reviewed
Proliferative Classification of Intracranially Injected HER2-positive Breast Cancer Cell Lines

Yuka Kuroiwa, Jun Nakayama, Chihiro Adachi, Takafumi Inoue, Shinya Watanabe, Kentaro Semba

Cancers, 12(7) 1811-1811, Jul 6, 2020 Peer-reviewed
Establishment and characterization of highly osteolytic luminal breast cancer cell lines by intra-caudal arterial injection

Han Y, Nakayama J, Hayashi Y, Jeong S, Futakuchi M, Ito E, Watanabe S, Semba K

Genes to Cells, 25(2) 111-123, Feb, 2020 Peer-reviewedLast author
Genetic manipulation of the mammary gland and potential applications.

Hiroaki Tagaya, Kentaro Semba, Kosuke Ishikawa

Oncotarget, 10(42) 4253-4254, Jul 2, 2019
A method of producing genetically manipulated mouse mammary gland.

Hiroaki Tagaya, Kosuke Ishikawa, Yoshito Hosokawa, Shun Kobayashi, Yukino Ueoka, Mayuna Shimada, Yasuko Ohashi, Hirofumi Mikami, Mizuki Yamamoto, Tatsuya Ihara …

Breast cancer research : BCR, 21(1) 1-1, Jan 5, 2019 Peer-reviewed
A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes.

Kosuke Ishikawa, Yuta Kobayashi, Yutaro Wakabayashi, Shinya Watanabe, Kentaro Semba

Biology methods & protocols, 3(1) bpy003, 2018 Peer-reviewed
An in vivo screening system to identify tumorigenic genes

T. Ihara, Y. Hosokawa, K. Kumazawa, K. Ishikawa, J. Fujimoto, M. Yamamoto, T. Muramkami, N. Goshima, E. Ito, S. Watanabe …

ONCOGENE, 36(14) 2023-2029, Apr, 2017 Peer-reviewed
Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui, Jiro Fujimoto, Kosuke Ishikawa, Emi Ito, Naoki Goshima, Shinya Watanabe, Kentaro Semba

FEBS LETTERS, 590(8) 1211-1221, Apr, 2016 Peer-reviewed
Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures

Ayano Doi, Kosuke Ishikawa, Nao Shibata, Emi Ito, Jiro Fujimoto, Mizuki Yamamoto, Hatsuki Shiga, Hiromi Mochizuki, Yoshifumi Kaulamura, Naoki Goshima …

MOLECULAR ONCOLOGY, 9(2) 355-364, Feb, 2015 Peer-reviewed
Gene amplification: mechanisms and involvement in cancer.

Matsui, A, Ihara, T, Suda, H, Mikami, H, Semba, K

Biomol Concepts, 4(6) 567-582, 2013
Expression screening of 17q12-21 amplicon reveals GRB7 as an ERBB2-dependent oncogene

Makoto Saito, Yukiko Kato, Emi Ito, Jiro Fujimoto, Kosuke Ishikawa, Ayano Doi, Kentaro Kumazawa, Atsuka Matsui, Shiori Takebe, Takaomi Ishida …

FEBS LETTERS, 586(12) 1708-1714, Jun, 2012 Peer-reviewed
NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells

Noritaka Yamaguchi, Tetsunari Oyama, Emi Ito, Hitoshi Satoh, Sakura Azuma, Mitsuhiro Hayashi, Ken Shimizu, Reiko Honma, Yuka Yanagisawa, Akira Nishikawa …

CANCER RESEARCH, 68(6) 1881-1888, Mar, 2008 Peer-reviewed
FoxA1 as a lineage-specific oncogene in luminal type breast cancer

Noritaka Yamaguchi, Emi Ito, Sakura Azuma, Reiko Honma, Yuka Yanagisawa, Akira Nishikawa, Mika Kawamura, Jun-ichi Imai, Kuniaki Tatsuta, Jun-ichiro Inoue …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 365(4) 711-717, Jan, 2008
Novel clusters of highly expressed genes accompany genomic amplification in breast cancers

Emi Ito, Reiko Honma, Yuka Yanagisawa, Jun-Ichi Imai, Sakura Azuma, Tetsunari Oyama, Susumu Ohwada, Tetsu Akiyama, Nobuo Nomura, Jun-Ichiro Inoue …

FEBS LETTERS, 581(21) 3909-3914, Aug, 2007 Peer-reviewed

Misc.

Classification and Metastatic Potential Assessment based on Nuclear Receptor Expression

中道和也, 中山淳, 仙波憲太郎, 仙波憲太郎

日本がん転移学会学術集会・総会プログラム抄録集, 32nd, 2023
Functional analysis of TIE1 in highly lung metastatic breast cancer cell line

東和志, 中山淳, 仙波憲太郎, 仙波憲太郎

日本がん転移学会学術集会・総会プログラム抄録集, 32nd, 2023
Single-cell meta-analysis of public datasets in multiple myeloma patients

中道和也, 中道和也, 中山淳, 中山淳, 仙波憲太郎, 仙波憲太郎, 山本雄介

日本分子生物学会年会プログラム・要旨集(Web), 46th, 2023
Functional analysis of mutant CDH1 in invasive lobular carcinoma.

東和志, 中山淳, 中山淳, 仙波憲太郎, 仙波憲太郎

日本分子生物学会年会プログラム・要旨集(Web), 46th, 2023
The mechanism of maintenance of HER2 expression in breast cancer

片山翔太, 中山淳, 仙波憲太郎, 仙波憲太郎

日本分子生物学会年会プログラム・要旨集(Web), 46th, 2023
Evaluation of metastatic ability in NMuMG-HOXB7 cells by orthotopic transplantation

東和志, 中山淳, 仙波憲太郎, 仙波憲太郎

日本分子生物学会年会プログラム・要旨集(Web), 45th, 2022
Evaluation of metastatic ability in NMuMG-HOXSB7 cells by orthotopic transplantation

東和志, 中山淳, 仙波憲太郎, 仙波憲太郎

日本がん分子標的治療学会学術集会プログラム・抄録集, 26th, 2022
Investigation of Cancer Reclassification by the HIF1 Downstream Genes

中道和也, 中山淳, 仙波憲太郎, 仙波憲太郎

日本がん転移学会学術集会・総会プログラム抄録集, 31st, 2022
Evaluation of Metastatic Ability in NMuMG-HOXB7 Cells by Orthotopic Transplantation

東和志, 中山淳, 仙波憲太郎, 仙波憲太郎

日本がん転移学会学術集会・総会プログラム抄録集, 31st, 2022
Characterization of Cell-in-Cell structure formation in breast cancer cell lines

林祐介, 林祐介, 中山淳, 仙波憲太郎, 仙波憲太郎, 山本雄介

日本癌学会学術総会抄録集(Web), 81st, 2022
Characterization of Luminal High-Osteolytic Breast Cancer Cell Lines

韓宇軒, 韓宇軒, 中山淳, 中山淳, 二口充, 伊藤恵美, 渡邉慎哉, 仙波憲太郎, 仙波憲太郎

日本癌学会学術総会抄録集(Web), 81st, 2022
Analysis of the androgen responsiveness in breast cancer

黒岩由佳, 黒岩由佳, 黒岩由佳, 伊藤景紀, 伊藤景紀, 中山淳, 中山淳, 仙波憲太郎, 仙波憲太郎, 山本雄介

日本癌学会学術総会抄録集(Web), 81st, 2022
Spatial transcriptomics reveals the two cancer stem cell-like populations in triple-negative breast cancer

Jun Nakayama, Hiroko Matsunaga, Koji Arikawa, Takuya Yoda, Masahito Hosokawa, Haruko Takeyama, Yusuke Yamamoto, Kentaro Semba

bioRxiv, Oct 21, 2021
PHLDA3機能欠損によるAktの活性化は細胞の分化と代謝異常を引き起こし、膵臓神経内分泌腫瘍の悪性化を促進する

陳ヨ, 岩淵禎弘, 清野透, 平岡伸介, 飯田渓太, 新井康仁, 横山明彦, 岡田眞里子, 橋本真一, 仙波憲太郎 …

日本癌学会総会記事, 80回 [J4-3], Sep, 2021
同所性乳がん高転移株におけるNIKの機能解析

林祐介, 中山淳, 山本瑞生, 井上純一郎, 山本雄介, 仙波憲太郎

日本癌学会総会記事, 80回 [J10-2], Sep, 2021
乳がんにおいてアンドロゲン受容体は細胞老化を誘導する

黒岩由佳, 中山淳, 仙波憲太郎, 山本雄介

日本癌学会総会記事, 80回 [P8-7], Sep, 2021
高悪性度漿液性卵巣がんにおける受容体型チロシンキナーゼTIE1の機能解析

松山貴弥, 中山淳, 渡辺慎哉, 山本雄介, 仙波憲太郎

日本癌学会総会記事, 80回 [P10-4], Sep, 2021
Investigation of Cancer Reclassification by the HIF1 downstream genes.

中道和也, 中山淳, 仙波憲太郎, 仙波憲太郎

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
Analysis of microheterogeneity in the breast cancer orthotopic xenograft model

中山淳, 中山淳, 仙波憲太郎, 仙波憲太郎, 山本雄介

日本がん転移学会学術集会・総会プログラム抄録集, 30th, 2021
Establishment of novel brain metastasis evaluation system in HER2-positive breast cancer

黒岩由佳, 黒岩由佳, 中山淳, 中山淳, 山本雄介, 仙波憲太郎, 仙波憲太郎

日本がん転移学会学術集会・総会プログラム抄録集, 30th, 2021

Teaching Experience

Professional Memberships

Research Projects

正常―がん細胞間作用に基づくがん防御機構の化学生物学的解析

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2024

仙波憲太郎
Functional analysis of ubiquitin E3 complex scaffold protein,Cullin-3 in breast cancer cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Murakami Akari, Maekawa Masashi, Kawai Katsuhisa, Nakayama Jun, Araki Nobukazu, Semba Kentaro, Taguchi Tomohiko, Kamei Yoshiaki, Takada Yasutsugu, Higashiyama Shigeki
Screening for genes involved in efficient reprogramming directly into mammary stem cells

Apr, 2015 - Mar, 2017
Generation of mammary stem cells by direct reprogramming

Apr, 2013 - Mar, 2015
Development of experimental techniques for the analysis of amplicomics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

SEMBA Kentaro, ITO Emi, IMAI Junichi, WATANABE Shinya, WAGURI Satoshi, ISOGAI Takao, GOSHIMA Naoki
Identification and functional analysis of novel oncogenes involved in the breast cancer genesis and promotion

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

SEMBA Kentaro
Molecular mechanism of sex determination and its disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

SEMBA Kentaro, WATANABE Shinya
Molecular mechanism of sex determination and its disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

SEMBA Kentaro, WATANABE Shinya
Tリンパ球抗原レセプターに会合するチロシン燐酸化酵素Fynの機能

科学研究費助成事業, 一般研究(B), 日本学術振興会, 1991 - 1992

片桐拓也, 鈴木元, 大海忍, 仙波憲太郎, 豊田裕
srcファミリー遺伝子fynのリンホーマ並びに正常リンパ球における発現と機能
がん遺伝子の検出と機能解析
がん遺伝子の機能解析
Srcファミリ-遺伝子fynのリンホ-マ並びに正常リンパ球における発現と機能
がんの増殖と分化に関連する遺伝子の発現制御
がん遺伝子の機能解析
細胞癌化における蛋白質リン酸化
Information Exchange on Cancer Research with North American
小児腎腫瘍の発症メカニズムの解析
転写制御の異常と細胞の増殖・分化
白血病細胞における細胞骨格・転写・細胞周期の制御異常

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