MISC

2011年

Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance

INTERNAL MEDICINE
  • Keita Inoue
  • ,
  • Fuminao Takeshima
  • ,
  • Koichiro Kadota
  • ,
  • Aya Yoda
  • ,
  • Yoichi Tatsuta
  • ,
  • Yuki Nagaura
  • ,
  • Sumako Yoshioka
  • ,
  • Seiko Nakamichi
  • ,
  • Kazuhiko Nakao
  • ,
  • Yoshiyuki Ozono

50
7
開始ページ
707
終了ページ
712
記述言語
英語
掲載種別
DOI
10.2169/internalmedicine.50.4600
出版者・発行元
JAPAN SOC INTERNAL MEDICINE

Background Tobacco smoking is a major risk factor for atherosclerotic and cardiovascular disease. Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease.
Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance.
Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use.
Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4 +/- 1.0 mu g/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8 +/- 0.9 mu g/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4 +/- 0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study.
Conclusion Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.50.4600
CiNii Articles
http://ci.nii.ac.jp/naid/130000650043
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000289999000008&DestApp=WOS_CPL
ID情報
  • DOI : 10.2169/internalmedicine.50.4600
  • ISSN : 0918-2918
  • CiNii Articles ID : 130000650043
  • Web of Science ID : WOS:000289999000008

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