Jan 1, 2019
Risk of developing type 2 diabetes according to blood pressure levels and presence or absence of hypertensive treatment: the Saku study
Hypertension Research
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- Volume
- 42
- Number
- 1
- First page
- 105
- Last page
- 113
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1038/s41440-018-0121-6
- Publisher
- NATURE PUBLISHING GROUP
© 2018, The Japanese Society of Hypertension. The aim was to investigate the risk of developing type 2 diabetes according to blood pressure (BP) levels and presence or absence of hypertensive treatment. This 5-year cohort study comprised 3508 Japanese adults aged 30–74 years without diabetes who had undergone a medical checkup including a 75-g oral glucose tolerance test (OGTT) between April 2008 and March 2009 at Saku Central Hospital. Participants receiving antihypertensive treatment were categorized into controlled hypertension (< 140/90 mmHg) or uncontrolled hypertension (≥ 140/90 mmHg) groups. Participants not receiving antihypertensive treatment were categorized: optimal BP (< 120/80 mmHg), normal BP (120–129/80–84 mmHg), high-normal BP (130–139/85–89 mmHg), grade I hypertension (140–159/90–99 mmHg), and grade II/III hypertension (≥ 160/100 mmHg). Hazard ratios and 95% confidence intervals for the incidence of type 2 diabetes as defined by the 75-g OGTT were estimated using multivariable-adjusted Cox proportional hazard models in reference to optimal BP. During an average of 4.4 years of follow-up, 295 participants developed type 2 diabetes. Those with high-normal BP, grade I hypertension, grade II/III hypertension, and uncontrolled hypertension were at significantly higher risk for developing type 2 diabetes, with hazard ratios (95% confidence intervals) of 1.53 (1.03–2.29), 1.53 (1.02–2.32), 2.19 (1.01–4.77), and 1.81 (1.10–2.99), respectively. In conclusion, compared with those with optimal BP, individuals with BP ≥ 130/85 mmHg not receiving antihypertensive treatment and uncontrolled hypertensives with BP ≥ 140/90 mmHg receiving antihypertensive treatment were at a significantly higher risk for developing type 2 diabetes.
- Link information
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- DOI
- https://doi.org/10.1038/s41440-018-0121-6
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30393378
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000455031100013&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056117896&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85056117896&origin=inward
- ID information
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- DOI : 10.1038/s41440-018-0121-6
- ISSN : 0916-9636
- eISSN : 1348-4214
- Pubmed ID : 30393378
- SCOPUS ID : 85056117896
- Web of Science ID : WOS:000455031100013