中尾一彦 (Kazuhiko Nakao) - マイポータル

基本情報

所属: 長崎大学大学院医歯薬学総合研究科医療科学専攻教授

学位: 博士(医学)(長崎大学)

J-GLOBAL ID: 200901010543369962
researchmap会員ID: 1000185828

外部リンク: http://www.med.nagasaki-u.ac.jp/gastro/index.html

研究キーワード

研究分野

ライフサイエンス / 消化器内科学 /

経歴

2009年 - 現在

長崎大学大学院医歯薬学総合研究科（医学系）教授
2009年 - 2014年

Professor,Graduate School of Biomedical Science,Graduate School of Biomedical Sciences,Nagasaki University

学歴

- 1983年

長崎大学, 医学部
- 1983年

長崎大学

委員歴

論文

246

PNPLA3 as a liver steatosis risk factor following living-donor liver transplantation for hepatitis C

Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Hidetaka Shibata, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi, Kazuhiko Nakao

Hepatology Research 48(3) E335-E339 2020年2月査読有り
Hepatitis C virus-related symptoms, but not quality of life, were improved by treatment with direct-acting antivirals

Tatsuki Ichikawa, Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Yasuhide Motoyoshi, Hiroshi Akahoshi, Satomi Nakamura, Junpei Nakamura, Youichi Takahashi, Tetsurou Honda …

Hepatology Research 48(3) E232-E239 2020年2月査読有り
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial.

Kudo M, Ueshima K, Ikeda M, Torimura T, Tanabe N, Aikata H, Izumi N, Yamasaki T, Nojiri S, Hino K …

Gut 69(8) 1492-1501 2019年12月査読有り
Response to Lenvatinib Is Associated with Optimal RelativeDose Intensity in Hepatocellular Carcinoma: Experience in Clinical Settings.

Ryu Sasaki, Masanori Fukushima, Masafumi Haraguchi, Satoshi Miuma, Hisamitsu Miyaaki, Masaaki Hidaka, Susumu Eguchi, Satoshi Matsuo, Kazuaki Tajima, Toshihisa Matsuzaki …

Cancers 11(11) 2019年11月10日査読有り
Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression.

Yuko Akazawa, Ryoma Nakashima, Katsuya Matsuda, Koji Okamaoto, Ran Hirano, Hiroko Kawasaki, Satoshi Miuma, Hisamitsu Miyaaki, Harmeet Malhi, Seigo Abiru …

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 32(7) 997-1007 2019年7月査読有り
A novel method for rapid detection of a Helicobacter pylori infection using a γ-glutamyltranspeptidase-activatable fluorescent probe.

Akashi T, Isomoto H, Matsushima K, Kamiya M, Kanda T, Nakano M, Onoyama T, Fujii M, Akada J, Akazawa Y …

Scientific reports 9(1) 9467-9467 2019年7月1日査読有り
Bacteroides in colonic mucosa-associated microbiota affects the development of minimal hepatic encephalopathy in patients with cirrhosis.

Masafumi Haraguchi, Satoshi Miuma, Hiroshi Masumoto, Tatsuki Ichikawa, Yasuko Kanda, Ryu Sasaki, Masanori Fukushima, Hisamitsu Miyaaki, Naota Taura, Kazuhiko Nakao

Hepatology international 13(4) 482-489 2019年7月査読有り
Identification of human herpes virus 1 encoded microRNAs in biopsy samples of lower esophageal sphincter muscle during peroral endoscopic myotomy for esophageal achalasia.

Ikebuchi Y, Kanda T, Ikeda H, Yoshida A, Sakaguchi T, Urabe S, Minami H, Nakao K, Kuwamoto S, Inoue H …

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 32(1) 136-142 2019年7月査読有り
Carotid Intima-media Thickness and Small Dense Low-density Lipoprotein Cholesterol Increase after One Year of Treatment with Direct-acting Antivirals in Patients with Hepatitis C Virus Infection.

Tatsuki Ichikawa, Hisamitsu Miyaaki, Satoshi Miuma, Yasuhide Motoyoshi, Syouhei Narita, Satomi Toda, Youichi Takahashi, Tetsurou Honda, Hiroyuki Yajima, Ryouhei Uehara …

Internal medicine (Tokyo, Japan) 58(9) 1209-1215 2019年5月1日査読有り
Direct-acting antiviral agents do not increase the incidence of hepatocellular carcinoma development: a prospective, multicenter study.

Ide T, Koga H, Nakano M, Hashimoto S, Yatsuhashi H, Higuchi N, Nakamuta M, Oeda S, Eguchi Y, Shakado S …

Hepatology international 13(3) 293-301 2019年5月査読有り
Predictors of hepatocellular carcinoma recurrence associated with the use of direct-acting antiviral agent therapy for hepatitis C virus after curative treatment: A prospective multicenter cohort study.

Nakano M, Koga H, Ide T, Kuromatsu R, Hashimoto S, Yatsuhashi H, Seike M, Higuchi N, Nakamuta M, Shakado S …

Cancer medicine 8(5) 2646-2653 2019年5月査読有り
A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.

Ryosuke Tateishi, Koji Uchino, Naoto Fujiwara, Tetsuo Takehara, Takeshi Okanoue, Masataka Seike, Hitoshi Yoshiji, Hiroshi Yatsuhashi, Masahito Shimizu, Takuji Torimura …

Journal of gastroenterology 54(4) 367-376 2019年4月査読有り
Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background

Arisa Yamashita, Tatsuo Inamine, Shota Suzuki, Sayaka Fukuda, Miki Unoike, Yuka Kawafuchi, Haruhisa Machida, Hajime Isomoto, Kazuhiko Nakao, Kazuhiro Tsukamoto

Immunology Letters 207 64-72 2019年3月査読有り
Changes in serum LDL, PCSK9 and microRNA-122 in patients with chronic HCV infection receiving Daclatasvir/Asunaprevir.

Tatsuki Ichikawa, Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Yasuhide Motoyoshi, Hiroshi Akahoshi, Junpei Nakamura, Youichi Takahashi, Tetsurou Honda, Hiroyuki Yajima …

Biomedical reports 10(3) 156-164 2019年3月査読有り
Early Gastric Cancer with Diffuse Lanthanum Deposition.

Tabuchi M, Takeshima F, Akazawa Y, Nakao K

Internal medicine (Tokyo, Japan) 58(3) 447-448 2019年2月査読有り
Risk Factors and Clinical Course for Liver Steatosis or Nonalcoholic Steatohepatitis after Living Donor Liver Transplantation

Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Hidetaka Shibata, Ryu Sasaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi, Kazuhiko Nakao

Transplantation 103(1) 109-112 2019年1月1日査読有り
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

Hitomi Y, Ueno K, Kawai Y, Nishida N, Kojima K, Kawashima M, Aiba Y, Nakamura H, Kouno H, Kouno H …

Scientific reports 9(1) 102 2019年1月査読有り
The Long-term Efficacy of Sodium Glucose Co-transporter 2 Inhibitor in Patients with Non-alcoholic Fatty Liver Disease.

Mio Yamashima, Hisamitsu Miyaaki, Satoshi Miuma, Hidetaka Shibata, Ryu Sasaki, Masafumi Haraguchi, Masanori Fukushima, Kazuhiko Nakao

Internal medicine (Tokyo, Japan) 58(14) 1987-1992 2019年査読有り
Anti-ganglionic AChR antibodies in Japanese patients with motility disorders.

Mukaino A, Minami H, Isomoto H, Hamamoto H, Ihara E, Maeda Y, Higuchi O, Okanishi T, Kokudo Y, Deguchi K …

Journal of gastroenterology 53(12) 1227-1240 2018年12月査読有り
The role of pancreatic juice cytology in the diagnosis of pancreatic intraductal papillary mucinous neoplasm.

Mohammed Tag-Adeen, Eisuke Ozawa, Kumi Ogihara, Shinichi Iwatsu, Yuko Akazawa, Ken Ohnita, Tomohiko Adachi, Yorihisa Sumida, Kazuhiko Nakao

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 110(12) 775-781 2018年12月査読有り

もっとみる

MISC

Relationship between Regulatory T Cells and the Combination of Pegylated Interferon and Ribavirin for the Treatment of Chronic Hepatitis Type C

Motohisa Akiyama, Tatuki Ichikawa, Hisamitsu Miyaaki, Yasuhide Motoyoshi, Shigeyuki Takeshita, Eisuke Ozawa, Satoshi Miuma, Hidetaka Shibata, Naota Taura, Kazuhiko Nakao

INTERVIROLOGY 53(3) 154-160 2010年
Study of liver-targeted regulatory T cells in hepatitis B and C virus in chronically infected patients

Hisamitsu Miyaaki, Huijuan Zhou, Tatsuki Ichikawa, Kazuhiko Nakao, Hidetaka Shibata, Shigeyuki Takeshita, Motohisa Akiyama, Eisuke Ozawa, Satoshi Miuma, Katsumi Eguchi

LIVER INTERNATIONAL 29(5) 702-707 2009年5月
Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis

Mariko Kusaba, Kazuhiko Nakao, Takashi Goto, Daisuke Nishimura, Hiroshi Kawashimo, Hidetaka Shibata, Yasuhide Motoyoshi, Naota Taura, Tatsuki Ichikawa, Keisuke Hamasaki …

JOURNAL OF HEPATOLOGY 47(4) 546-555 2007年10月
Antiangiogenic property of pigment epithelium-derived factor in hepatocellular carcinoma

K Matsumoto, H Ishikawa, D Nishimura, K Hamasaki, K Nakao, K Eguchi

HEPATOLOGY 40(1) 252-259 2004年7月
Bone marrow engraftment in a rodent model of chemical carcinogenesis but no role in the histogenesis of hepatocellular carcinoma.

Ishikawa H, Nakao K, Matsumoto K, Nishimura D, Ichikawa T, Hamasaki K, Eguchi K

Gut 53 884-889 2004年
Bone marrow engraftment in a rodent model of chemical carcinogenesis but no role in the histogenesis of hepatocellular carcinoma.

Ishikawa H, Nakao K, Matsumoto K, Nishimura D, Ichikawa T, Hamasaki K, Eguchi K

Gut 53 884-889 2004年
Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells

S Abiru, K Nakao, T Ichikawa, K Migita, M Shigeno, M Sakamoto, H Ishikawa, K Hamasaki, K Nakata, K Eguchi

HEPATOLOGY 35(5) 1117-1124 2002年5月
Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults

American Journal of Gastroenterology 97/7, 1796-1801 2002年
Association between nonalcoholic fatty liver, markers of obesity, and serum leptin level in young adults

American Journal of Gastroenterology 97/7, 1796-1801 2002年
Gerany Igeraniol, an intermediate product in meralonate pathway, induces apoptotic cell death in human hepatoma cells; death receptor-independent activation of caspase-8 with down-regulation of BCl-xL expression

Ichikawa T, Nakao K, Nakata K, Hamasaki K, Takeda Y, Kajiya Y, Higashi S, Ohkubo K, Kato Y, Ishii N …

Japanese Journal of Cancer Research 92/9, 918-925 2001年
Gerany Igeraniol, an intermediate product in meralonate pathway, induces apoptotic cell death in human hepatoma cells; death receptor-independent activation of caspase-8 with down-regulation of BCl-xL expression

Japanese Journal of Cancer Research 92/9, 918-925 2001年
Gerany Igeraniol, an intermediate product in meralonate pathway, induces apoptotic cell death in human hepatoma cells; death receptor-independent activation of caspase-8 with down-regulation of BCl-xL expression

Japanese Journal of Cancer Research 92/9, 918-925 2001年
p48 (ISGF-32) is involved in interferon-α-induced suppression of hepatitis B virus enhancer-1 activity

Nakao K, Nakata K, Yamashita M, Tamada Y, Hamasaki K, Ishikawa H, Kato Y, Eguchi K, Ishii N

The Journal of Biological chemistry 274(40) 28075-28078 1999年10月
p48 (ISGF-3 gamma) is involved in interferon-alpha-induced suppression of hepatitis B virus enhancer-1 activity

K Nakao, K Nakata, M Yamashita, Y Tamada, K Hamasaki, H Ishikawa, Y Kato, K Eguchi, N Ishii

JOURNAL OF BIOLOGICAL CHEMISTRY 274(40) 28075-28078 1999年10月
Activation of Caspase-8 in Transforming Growth Factor-β-Induced Apoptosis of Human Hepatoma Cells

Hepatology 5/30,1215-1222 1999年
Effect of simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on α-fetoprotein gene expression through interaction with the ras-mediated pathway

Journal of Hepatology 30/5,904-910 1999年
Utilization of variant-type of human α-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma

Gene Therapy 6/4,465-470 1999年
Activation of Caspase-8 in Transforming Growth Factor-β-Induced Apoptosis of Human Hepatoma Cells

Hepatology 5/30,1215-1222 1999年
Effect of simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on α-fetoprotein gene expression through interaction with the ras-mediated pathway

Journal of Hepatology 30/5,904-910 1999年
Utilization of variant-type of human α-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma

Gene Therapy 6/4,465-470 1999年

もっとみる

講演・口頭発表等

早期胃癌に対するESD治療後の長期経過の検討

日本消化器内視鏡学会 2010年
慢性肝疾患診療の今日

日本医療薬学会年会 2009年

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

肝細胞アポトーシス機構の研究

2000年
Biochemical pathways leading to apotosis of hepatocytes

2000年
肝細胞におけるインターフェロンシグナル伝達の解析

1999年
Analysis of Interteron Signaling pathway in human hepatocytes

1999年
肝癌に対する新規治療法の開発

1995年
The development of the new therapy for the liver cancer

1995年