Masato Okada

Profile Information

Affiliation: Professor, Research Institute for Microbial Diseases, Osaka University

Degree: D.Sc.(Osaka University)

Researcher number: 10177058
J-GLOBAL ID: 200901010189604800
researchmap Member ID: 1000185885

External link: http://www.biken.osaka-u.ac.jp/kenkyu/gan/hatugan.html

Research Interests

Research Areas

Research History

Nov, 2000 - Present

Professor, Department of oncogene research, Research Institute for Microbial Diseases, Osaka University
Aug, 1996 - Oct, 2000

Associate professor, Division of protein metabolism, Institute for Protein Research, Osaka University
Apr, 1985 - Jul, 1996

Research assistant, Division of protein research, Institute for Protein Research, Osaka University

Education

Apr, 1983 - Mar, 1985

Department of biological sciences, Graduate School of Science, Osaka University
Apr, 1981 - Mar, 1983

Department of Biological Sciences, Graduate School of Science, Osaka University
Apr, 1976 - Mar, 1981

Chemistry, Faculty of Science, Kyoto University

Awards

1995

日本生化学会奨励賞

岡田雅人
1994

日本癌学会奨励賞

岡田雅人

Papers

151

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses.

Masako Kohyama, Tatsuya Suzuki, Wataru Nakai, Chikako Ono, Sumiko Matsuoka, Koichi Iwatani, Yafei Liu, Yusuke Sakai, Atsushi Nakagawa, Keisuke Tomii, Koichiro Ohmura, Masato Okada, Yoshiharu Matsuura, Shiro Ohshima, Yusuke Maeda, Toru Okamoto, Hisashi Arase

International immunology, Sep 2, 2022 Peer-reviewed
Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition.

Kentaro Kajiwara, Ping-Kuan Chen, Yuichi Abe, Satoru Okuda, Shunsuke Kon, Jun Adachi, Takeshi Tomonaga, Yasuyuki Fujita, Masato Okada

Current biology : CB, 32(16) 3460-3476, Aug 22, 2022 Peer-reviewed
LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.

Emi Fujibayashi, Satomi Mukai, Kosuke Torigata, Yumi Ando, Toshihiro Uchihashi, Masami Nozaki, Susumu Tanaka, Masato Okada, Mikihiko Kogo, Hiroshi Nojima, Norikazu Yabuta

Scientific reports, 12(1) 12363-12363, Jul 20, 2022 Peer-reviewed
Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses.

Tomokazu Tamura, Shiho Torii, Kentaro Kajiwara, Itsuki Anzai, Yoichiro Fujioka, Kisho Noda, Shuhei Taguwa, Yuhei Morioka, Rigel Suzuki, Yuzy Fauzyah, Chikako Ono, Yusuke Ohba, Masato Okada, Takasuke Fukuhara, Yoshiharu Matsuura

PLoS pathogens, 18(6) e1010593, Jun 1, 2022 Peer-reviewed
SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.

Naoyuki Kawase, Atsuya Sugihara, Kentaro Kajiwara, Michio Hiroshima, Kanako Akamatsu, Shigeyuki Nada, Kunio Matsumoto, Masahiro Ueda, Masato Okada

The Journal of biological chemistry, 298(3) 101630-101630, Mar 1, 2022 Peer-reviewed
The Ragulator complex serves as a substrate-specific mTORC1 scaffold in regulating the nuclear translocation of transcription factor EB.

Tetsuya Kimura, Yoshitomo Hayama, Daisuke Okuzaki, Shigeyuki Nada, Masato Okada

The Journal of biological chemistry, 298(3) 101744-101744, Mar 1, 2022 Peer-reviewed
d-Serine Mediates Cellular Proliferation for Kidney Remodeling.

Atsushi Hesaka, Yusuke Tsukamoto, Shigeyuki Nada, Masataka Kawamura, Naotsugu Ichimaru, Shinsuke Sakai, Maiko Nakane, Masashi Mita, Daisuke Okuzaki, Masato Okada, Yoshitaka Isaka, Tomonori Kimura

Kidney360, 2(10) 1611-1624, Oct 28, 2021 Peer-reviewed
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.

Yafei Liu, Wai Tuck Soh, Jun-Ichi Kishikawa, Mika Hirose, Emi E Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, Sumiko Matsuoka, Kanako Akamatsu, Makoto Matsuda, Chikako Ono, Shiho Torii, Kazuki Kishida, Hui Jin, Wataru Nakai, Noriko Arase, Atsushi Nakagawa, Maki Matsumoto, Yukoh Nakazaki, Yasuhiro Shindo, Masako Kohyama, Keisuke Tomii, Koichiro Ohmura, Shiro Ohshima, Toru Okamoto, Masahiro Yamamoto, Hironori Nakagami, Yoshiharu Matsuura, Atsushi Nakagawa, Takayuki Kato, Masato Okada, Daron M Standley, Tatsuo Shioda, Hisashi Arase

Cell, 184(13) 3452-3466, Jun 24, 2021 Peer-reviewed
The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Takeshi Nakatani, Kohei Tsujimoto, Jeong Hoon Park, Tatsunori Jo, Tetsuya Kimura, Yoshitomo Hayama, Hachiro Konaka, Takayoshi Morita, Yasuhiro Kato, Masayuki Nishide, Shyohei Koyama, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

Nature Communications, 12(1), Jun 1, 2021 Peer-reviewed
CDCP1 promotes compensatory renal growth by integrating Src and Met signaling

Kentaro Kajiwara, Shotaro Yamano, Kazuhiro Aoki, Daisuke Okuzaki, Kunio Matsumoto, Masato Okada

Life Science Alliance, 4(4), Apr 1, 2021 Peer-reviewed
Src mediates TGF-β-induced intraocular pressure elevation in glaucoma

Teruhisa Tsukamoto, Kentaro Kajiwara, Shigeyuki Nada, Masato Okada

Journal of Cellular Physiology, 234(2) 1730-1744, Feb, 2021 Peer-reviewed
β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Woei Yaw Chee, Yuriko Kurahashi, Junhyeong Kim, Kyoko Miura, Daisuke Okuzaki, Tohru Ishitani, Kentaro Kajiwara, Shigeyuki Nada, Hideyuki Okano, Masato Okada

Communications Biology, 4(1), Dec 1, 2020 Peer-reviewed
Genetic dissection of ragulator structure and function in amino acid-dependent regulation of mTORC1

Shigeyuki Nada, Masato Okada

Journal of Biochemistry, 168(6) 621-632, Dec 1, 2020 Peer-reviewed
Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity

Yao Yao, Sungki Hong, Takayuki Ikeda, Hiroyuki Mori, Ormond A. MacDougald, Shigeyuki Nada, Masato Okada, Ken Inoki

Molecular Cell, 80(3) 437-4.51E+08, Nov 5, 2020 Peer-reviewed
Atg5-mediated autophagy controls apoptosis/anoikis via p53/Rb pathway in naked mole-rat fibroblasts

Junhyeong Kim, Woei Yaw Chee, Norikazu Yabuta, Kentaro Kajiwara, Shigeyuki Nada, Masato Okada

Biochemical and Biophysical Research Communications, 528(1) 146-153, Jul 12, 2020 Peer-reviewed
Ubiquitination of Src promotes its secretion via small extracellular vesicles

Kentaro Tanaka, Yuko Ito, Kentaro Kajiwara, Shigeyuki Nada, Masato Okada

Biochemical and Biophysical Research Communications, 525(1) 184-191, Apr, 2020 Peer-reviewed
P18/lamtor1-mtorc1 signaling controls development of mucin-producing goblet cells in the intestine

Shizuka Ito, Shigeyuki Nada, Daisuke Yamazaki, Tetsuya Kimura, Kentaro Kajiwara, Hiroaki Miki, Masato Okada

Cell Structure and Function, 45(2) 93-105, 2020 Peer-reviewed
CDCP1 controls compensatory renal growth by integrating Src and Met signaling

Kajiwara K, Aoki K, Okuzaki D, Matsumoto K, Okada M

bioRxiv, Oct, 2019
Lysosomal protein Lamtor1 controls innate immune responses via nuclear translocation of transcription factor EB

Yoshitomo Hayama, Tetsuya Kimura, Yoshito Takeda, Shigeyuki Nada, Shohei Koyama, Hyota Takamatsu, Sujin Kang, Daisuke Ito, Yohei Maeda, Masayuki Nishide, Satoshi Nojima, Hana Sarashina-Kida, Takashi Hosokawa, Yuhei Kinehara, Yasuhiro Kato, Takeshi Nakatani, Yoshimitsu Nakanishi, Takeshi Tsuda, Taro Koba, Masato Okada, Atsushi Kumanogoh

Journal of Immunology, 200(11) 3790-3800, Jun 1, 2018 Peer-reviewed
Rheb localized on the Golgi membrane activates lysosomelocalized mTORC1 at the Golgi-lysosome contact site

Feike Hao, Kazuhiko Kondo, Takashi Itoh, Sumiko Ikari, Shigeyuki Nada, Masato Okada, Takeshi Noda

Journal of Cell Science, 131(3), Feb 1, 2018 Peer-reviewed

Misc.

A novel intragenic enhancer regulates TGF-β-induced SRC expression.

野下創史, 野下創史, 久保祐貴, 久保祐貴, 西田裕毅, 西田裕毅, 奥崎大介, 岡田雅人

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
Spatiotemporal regulation of Src signaling in compensatory renal growth

梶原健太郎, 山野荘太郎, 青木一洋, 奥崎大介, 松本邦夫, 岡田雅人

日本細胞生物学会大会(Web), 73rd, 2021
CDCP1細胞外領域の構造基盤の解明

杉本楓, 赤松香奈子, 松田真, 梶原健太郎, 山下栄樹, 中川敦史, 岡田雅人

日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
ハダカデバネズミ細胞におけるオートファジーの機能解析

KIM Junhyeong, 名田茂之, 岡野栄之, 三浦恭子, 岡田雅人

日本細胞生物学会大会(Web), 71st ROMBUNNO.1P‐314 (WEB ONLY), 2019
ハダカデバネズミ細胞を用いた老化におけるFOXOの機能解析

Kim Junhyeong, 名田成之, 森俊介, 岡野栄之, 三浦恭子, 岡田雅人

生命科学系学会合同年次大会, 2017年度 [2P-0976], Dec, 2017
髄鞘形成におけるリソソーム膜タンパク質LAMTOR1の役割

砂堀毅彦, 名田茂之, 岡田雅人, 内山安男, 小池正人

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 122nd 147, 2017
Ragulator‐Rag GTPase複合体形成の構造基盤

中井昌弘, 岡田雅人, 名田茂之, 小川輝, 北村絢香, 中井友和, 中川敦史, 山下栄樹, 米原涼, 中山敬一, 中津海洋一

日本生化学会大会(Web), 90th ROMBUNNO.1P‐0130 (WEB ONLY), 2017
Ragulatorの構造とRagとの複合体形成機構

名田茂之, 米原涼, 中井昌弘, 北村彩佳, 小川輝, 山下栄樹, 中川敦史, 岡田雅人

日本生化学会大会(Web), 90th ROMBUNNO.1AW07‐6 (WEB ONLY), 2017
The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition

Y. Komiya, Y. Onodera, M. Kuroiwa, S. Nomimura, Y. Kubo, J. M. Nam, K. Kajiwara, S. Nada, C. Oneyama, H. Sabe, M. Okada

Oncogenesis, 5(9), Sep 12, 2016
IL-4はLamtor1を足場としてmTORC1を活性化し、LXRを介してM2マクロファージを分化させる

木村哲也, 名田成之, 岡田雅人, 熊ノ郷淳

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [2T特p-01(2P1150)], Dec, 2015
【知る・見る・活かす!シグナリング研究2015 シグナル伝達の要素発見から時空間ダイナミクスへ】 (第2章)シグナリングから見た生命現象その破綻と疾患の理解脂質ラフトによるSrcの空間的制御とがん進展

小根山千歳, 岡田雅人

実験医学, 33(10) 1580-1585, Jun, 2015 Invited
Paxillinを標的とするmiR-27bを介したSrcによるがん悪性化の制御(miR-27b controls c-Src-induced tumor progression by targeting Paxillin)

浅井麗伊, 奥崎大介, 池田純一郎, 森井英一, 岡田雅人, 小根山千歳

日本癌学会総会記事, 73回 J-1080, Sep, 2014
乳癌において変異p53がリガンド反応性の間葉型浸潤分子装置を創出する機序(TP53 alterations generate Arf6-based mesenchymal invasion pathway that is activated by RTKs and TGFβ1 in breast cancer)

橋本あり, 橋本茂, 杉野弘和, 吉河歩, 及川司, 小野寺康仁, 半田悠, 大塚勇太郎, 岩見昴亮, 小根山千歳, 岡田雅人, 福田光則, 佐邊壽孝

日本癌学会総会記事, 73回 J-2077, Sep, 2014
microRNAを介したmTORC2制御とがん形質発現(MicroRNA-mediated mTORC2 upregulation promotes tumor progression)

小根山千歳, 鬼頭頼子, 浅井麗伊, 角元恭子, 奥崎大介, 池田純一郎, 森井英一, 岡田雅人

日本癌学会総会記事, 72回 112-112, Oct, 2013
癌放射線治療への分子生物学的アプローチ変異p53が放射線抵抗性に根幹的な間葉型浸潤経路を創出する機構(Toward the improvement of radiotherapy: Approaches from the molecular biological point of view Mechanisms by which oncogenic mutant-p53 generates mesenchymal invasive pathway pivotal to a radiation resis

佐邊壽孝, 橋本あり, 橋本茂, 小野寺康仁, 及川司, Nam Jin-Min, 小根山千歳, 杉野弘和, 吉河歩, 大塚勇太郎, 半田悠, 芳野正修, 岡田雅人

日本癌学会総会記事, 72回 64-64, Oct, 2013
p53変異によるGEP100-Arf6-AMAP1経路の活性化と乳癌の浸潤形質獲得

橋本茂, 橋本あり, 小根山千歳, 吉河歩, 杉野弘和, 半田悠, 芳野正修, 大塚勇太郎, 小野寺康仁, 岡田雅人, 佐邊壽孝

日本生化学会大会(Web), 86th, 2013
C末端SrcキナーゼのSH2ドメインとCsk‐binding protein(Cbp)/phosphoprotein associated with glycosphingolipid microdomains(PAG)との間の新しい相互作用様式の発見

田中宏明, 赤木謙一, 小根山千歳, 田中雅千, 佐々木優一, 狩野孝, LEE Young‐Ho, 横川大輔, DOBENECKER Marc‐Werner, 中川敦史, 岡田雅人, 池上貴久

日本分子生物学会年会プログラム・要旨集(Web), 36th 1P-0078 (WEB ONLY), 2013
Regulation of the Src family kinases by Csk

Masato Okada

International Journal of Biological Sciences, 8(10) 1385-1397, Nov 1, 2012
Srcがん形質発現におけるmicroRNAを介したmTORC2制御(MicroRNA-mediated upregulation of mTORC2 promotes Src-induced tumorigenesis)

小根山千歳, 鬼頭頼子, 浅井麗伊, 角元恭子, 奥崎大介, 池田純一郎, 森井英一, 岡田雅人

日本癌学会総会記事, 71回 230-230, Aug, 2012
マイクロRNAはARFGEF1を標的とすることで、Srcによるがん悪性化を制御する(MicroRNA-mediated downregulation of ARFGEF1 controls Src-induced tumor progression)

浅井麗伊, 奥崎大介, 池田純一郎, 森井英一, 岡田雅人, 小根山千歳

日本癌学会総会記事, 71回 268-268, Aug, 2012

Books and Other Publications

医学のあゆみ「Srcによる細胞競合とがん進展」

梶原健太郎, 岡田雅人

医歯薬出版, Aug, 2020
タンパク質科学イラストレイテッド

竹縄忠臣, 岡田雅人, 小谷武徳, 伊東文祥 (Role: Contributor)

羊土社, Nov, 2005
リン酸化による修飾と機能発現

笠井篤子, 岡田雅人 (Role: Contributor)

メディカルドゥ, Jul, 2005
探索から機能解析へ向かうプロテオミクス時代のタンパク質研究

岡田雅人, 宮崎香

羊土社, Sep, 2002
タンパク質実験ノート（上・下）

岡田雅人, 宮崎香

羊土社, Sep, 1999
タンパク実験の進めかた

岡田雅人, 宮崎香

羊土社, Oct, 1998

Presentations

104

Src がん遺伝子産物の機能と制御 ― 電気泳動によるタンパク質化学からのアプローチ ―

岡田雅人

第70回日本電気泳動学会シンポジウム, Sep, 2020
アミノ酸依存的mTORC1栄養シグナルの制御と機能

名田茂之、伊藤静夏、山崎大輔、三木裕明、岡田雅人

第93回日本生化学会大会, Sep, 2020
Inactivation of Src family kinases by Csk contributes to germinal center maintenance.

松本侑真、井上毅、黒崎知博

第42回日本分子生物学会, Dec, 2019
HGF依存的な浸潤現象におけるCDCP1の役割

河瀬直之、杉原充哉、岡田雅人

第42回日本分子生物学会, Dec, 2019
The interconnection between β-catenin and Lipid Droplets in Naked Mole Rat: The Nexus for Cellular Metabolism and Senescence

Woei-Yaw Chee、Junhyeong Kim、Kyoko Miura、Tohru Ishitani、Masato Okada

第42回日本分子生物学会, Dec, 2019
肝細胞におけるLamtor1遺伝子の役割と脂質代謝への影響

池口弘太郎、木村哲也、岡田雅人

第42回日本分子生物学会, Dec, 2019
TGF-β１刺激がもたらすがん原遺伝子SRCの転写活性化機構の解明

野下創史、久保祐貴、西田裕毅、岡田雅人

第42回日本分子生物学会, Dec, 2019
腸管上皮におけるp18-mTORC1シグナル経路の生理機能の解析

伊藤静夏、名田茂之、岡田雅人

第42回日本分子生物学会, Dec, 2019
The interconnection between β-catenin and lipid droplets in naked mole rat: the nexus for cellular metabolism and senescence

Woei-Yaw Chee

清華大学ー大阪大学・国際学生シンポジュウム, Oct, 2019
The transmembrane glycoprotein CDCP1 controls HGF-dependent cancer cell invasion

Naoyuki Kawase, Masato Okada

清華大学ー大阪大学・国際学生シンポジュウム, Oct, 2019
The interconnection between β-catenin and lipid droplets in naked mole rat: the nexus for cellular metabolism and senescence

Woei-Yaw Chee

27th FAOBMB & 44th MSBMB Conference 2019, Aug, 2019
mTORC1シグナル制御の分子基盤とその破綻による病態解明

岡田雅人

新学術領域「数理シグナル」領域推進会議, Jun, 2019
The interconnection between β-catenin and Lipid Droplets in Naked Mole Rat: The Nexus for Cellular Metabolism and Senescence

Woei-Yaw Chee

第586回微研集談会, Jun, 2019
TGF-β１刺激がもたらすがん原遺伝子c-SRCの転写活性化機構の解明

野下創史

先端モデル動物支援プラットフォーム「若手支援技術講習会」, May, 2019
がん進展制御におけるSrcおよびmTORシグナルの役割

岡田雅人

がん進展制御研究所セミナーにて特別講演, Mar, 2019
Molecular basis for the regulation of mTORC1 nutrient signaling

Masato Okada

「数理シグナル」第1回国際シンポジウム, Feb, 2019
膜貫通タンパク質Rsp1はHGF依存性のがん細胞の浸潤を制御する

河瀬直之, 梶原健太郎, 岡田雅人

第12回若手研究フォーラム, Feb, 2019
Prevention of Obesity by Macrophages

Tetsuya Kimura, Masato Okada

第40回 IFReCコロキウム, Dec, 2018
The Conundrum of Naked-mole-rat, a species with both Strong Senescence mechanism and Major Oncogenic pathway

Woei-Yaw Chee、Junhyeong Kim、Shigeyuki Nada、Kyoko Miura、Masato Okada

第41回日本分子生物学会, Nov, 2018
がん発展におけるSrcチロシンキナーゼの立ち位置

岡田雅人

第91回日本生化学会大会, Sep, 2018

Teaching Experience

128

2020

Host Defense B (Cancer Biology)
2020

Host Defense A (Cancer Biology)
2019

Cell Biology B Ｈ
2019

Cell Biology B
2019

Advanced Lecture of Bioscience E1
2019

Advanced Lecture of Bioscience E1 (S)
2018

Literature Survey in Biology
2018

Special Biological Experiments in Laboratory
2018

Seminar for Advanced Researches
2018

Semestral Seminar
2018

Cell Biology B Ｈ
2018

Cell Biology B
2018

Seminar for Advanced Researches Research in Signal Transduction
2018

Semestral Seminar on Signal Transduction
2017

Semestral Seminar on Signal Transduction
2017

Seminar for Advanced Researches Research in Signal Transduction
2017

Advanced Lecture of Bioscience E1
2017

Semestral Seminar
2017

Advanced Lecture of Bioscience E1 (S)
2017

Cell Biology B

Professional Memberships

Research Projects

発生・分化におけるチロシンキナーゼの役割解析

その他の研究制度, 1991
蛋白質リン酸化の生理的役割

その他の研究制度, 1991
Functional analysis of protein tyrosine kinases in development and differentiation

The Other Research Programs
Physiological Roles of Protein Phosphorylation

The Other Research Programs

Profile Information

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Research History

Education

Awards

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Misc.

Books and Other Publications

Presentations

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