TSUTSUMI Yasuo

J-GLOBAL         Last updated: Aug 9, 2019 at 02:40
 
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Name
TSUTSUMI Yasuo
Affiliation
Osaka University
Section
Graduate School of Pharmaceutical Sciences Advanced Pharmaco-science
Job title
Professor

Research Areas

 
 

Published Papers

 
Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells.
Diao Y.Y, Li H.Y, Fu Y.H, Jiang H.L, Tsutsumi Y, Wei Q.C, Gao J.Q.
Int. J. Nanomedicine.      Sep 2011   [Refereed]
Narimatsu S, Yoshioka Y, Morishige T, Yao X, Tsunoda S, Tsutsumi Y, Nishimura MI, Mukai Y, Okada N, Nakagawa S.
Biochem. Biophys. Res. Commun      Oct 2011   [Refereed]
Narimatsu S, Yoshioka Y, Watanabe H, Masano T, Morishige T, Yao X, Tanabe A, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S.
Cytokine      Nov 2011   [Refereed]
Kitagaki M, Isoda K, Kamada H, Kobayashi T, Tsunoda S, Tsutsumi Y, Niida T, Kujiraoka T, Ishigami N, Ishihara M, Matsubara O, Ohsuzu F, Kikuchi M.
J. Atheroscler. Thromb.      Dec 2011   [Refereed]
Relation analysis between intracellular distribution of nanomateriarls, ROS generation and DNA damage.
Yoshida T, Yoshikawa T, Tsutsumi Y.
Yakugaku Zasshi      Dec 2011   [Refereed]

Misc

 
Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency.
Br. J. Cancer (British Journal of Cancer)   71 963-968   1995
Isolation and properties of tumor-derived endothelial cells from rat KMT-17 fibrosarcoma
Jpn. J. Cancer Res. (Japanese Journal of Cancer Research)   86 193-201   1995
Tumor-conditioned medium increases macromolecular permeability of endothelial cell monolayer
Cancer Letters   89 7-14   1995
Chemical modification of natural human tumor necrosis factor-α with polyethylene glycol increases its anti-tumor potency
Jpn. J. Cancer Res. (Japanese Journal of Cancer Research)   85 9-12   1994

Books etc

 
PEGylation of TNF-α drastically increases its anti-tumor potency.
Progress in Drug Delivery System (]G0002[) : Biiomedical Research Foundation, Tokyo   1993   
Biological Effects of Fibrous and Particulate Substances
Hirai T, Yoshioka Y, Higashisaka K, Tsutsumi Y (Part:Joint Work)
Springer   Jan 2016   ISBN:978-4-431-55732-6
Reproductive and developmental effects of nanomaterials
Morishita Y, Yoshioka Y, Higashisaka K, Tsutsumi Y (Part:Joint Work)
Springer   Jan 2016   ISBN:978-4-431-55731-9

Conference Activities & Talks

 
MicroRNA as a biomarker for the safety analysis of nanomaterials
SOT2012   Mar 2012   
The effect of in utero exposure to amorphous nanosilica particles on neonatal immune function and neurological function
SOT2012   Mar 2012   
Size-dependent aggravating-effect of amorphous silica nanoparticles on atopic dermatitis
SOT2012   Mar 2012   
Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles
SOT2012   Mar 2012   
Effect of surface properties of nanosilica on their in vitro safety
Jan 2012   
Development of biomarkers using a proteomics analysis toward ensuring safety of nanomaterials
Jan 2012   
Fundamental assessment for clarification of Relationship between Asian dust and influenza infection-1; Potential immunotoxicity of Asian dust for the future risk-analysis
SETAC North America 32nd Annual Meeting   Nov 2011   
Promotion of antigen-specific IgE production by intranasally-administrated nanosilica particles in mice
SETAC North America 32nd Annual Meeting   Nov 2011   
Fundamental assessment for clarification of Relationship between Asian dust and influenza infection-2; Biodistribution and inflammatory effects of Asian dust for the future risk-analysis
SETAC North America 32nd Annual Meeting   Nov 2011   
Safety analysis of silica particle for development of nanomedicine ~Developmental toxicity on placenta~
Nov 2011   
Safety evaluation of amorphous silica nanoparticles following intranasal exposure: Potential applications for nanoparticle-based intranasal drug delivery
Nov 2011   
Development of biomarkers of nanomaterials toward newly strategies ensuring safety and efficacy of nanomedicine
Nov 2011   
Creation of mouse TNFR2-selective TNF mutant using phage display system
9th Joint Meeting of ICS-ISICR   Oct 2011   
Biological and structural characterization of human TNFR2-selective TNF mutants
9th Joint Meeting of ICS-ISICR   Oct 2011   
Proteomic profiling of proteins associated with metastasis in colorectal cancer cell lines
Oct 2011   
The intradermal injections of amorphous nanosilica particles size-dependently aggravate the atopic dermatitis
Oct 2011   
Functional analysis of a novel breast cancer related protein, ephrin receptor A10
The 2011 European Multidisciplinary Cancer Congress   Sep 2011   
Possibility of Ephrin receptor A10 as a drug target in triple negative breast cancer
The 2011 European Multidisciplinary Cancer Congress   Sep 2011   
The relationship between oxysterol binding protein like 5 and calumenin during lymph node metastasis
The 2011 European Multidisciplinary Cancer Congress   Sep 2011   
The search for a biomarker of hepatic injury expressed by sinusoidal endothelial cells
HUPO2011   Sep 2011   
Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif
HUPO2011   Sep 2011   
Expression of Annexin A4 is related to cisplatin-susceptibility in mesothelioma cells
HUPO2011   Sep 2011   
Systemic distribution of amorphous nanosilica following topical application
EuroTox2011   Aug 2011   
Development of biomarkers for ensuring safety of nanomaterials
EuroTox2011   Aug 2011   
In vitro evaluation of the embryotoxic potency of amorphous nanosilica
EuroTox2011   Aug 2011   
Postnatal effects of prenatal treatment of amorphous nanosilica
EuroTox2011   Aug 2011   
Effect of surface properties of nanosilica on their in vitro safety
EuroTox2011   Aug 2011   
The safety assessment of amorphous nanosilica following dermal exposure
EuroTox2011   Aug 2011   
Solution of the Structure of the TNF-TNFR2 Complex
International Union of Crystallography (IUCr) 2011   Aug 2011   
Creation of TNFR1-selective mutant TNF with antagonistic activity.
XXIII Congress of the International Society of Thrombosis and Haemostasis   Jul 2011   
Toxico-proteomic analysis and identification of biomarkers for nano-safety science
Jun 2011   

Works

 
Creation of functional antibodeis
2002

Research Grants & Projects

 
Molecular Design of Multi-Functional Hybrid Drug
Development of Targeting Therapy for Cancer
Study on drug delivery system for vaccine
Creation of functional muteins

Patents

 
Tumor-tissue endothelium-specific monoclonal antibody
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Intracellular delivery vector
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