Makio Saeki

Profile Information

Affiliation: Graduate School of Medical and Dental Sciences, Oral Life Science, Niigata University

Degree: Doctor of Philosophy(Osaka University)

Researcher number: 30273692
J-GLOBAL ID: 200901025551854869
researchmap Member ID: 1000185990

External link: http://www.dent.niigata-u.ac.jp/pharmacology/pharmacology.html

Papers

Involvement of Rab11 in osteoblastic differentiation: Its up-regulation during the differentiation and by tensile stress.

Lay Thant, Yoshito Kakihara, Masaru Kaku, Megumi Kitami, Kohei Kitami, Masaru Mizukoshi, Takeyasu Maeda, Isao Saito, Makio Saeki

Biochemical and biophysical research communications, 624 16-22, Jul 19, 2022
Cell-Based Double-Screening Method to Identify a Reliable Candidate for Osteogenesis-Targeting Compounds

Sho Fukuyasu, Hiroki Kayashima, Akihito Moribayashi, Shu Matsuoka, Atsuhiro Nagasaki, Hiroko Okawa, Hirofumi Yatani, Makio Saeki, Hiroshi Egusa

Biomedicines, 10(2) 426-426, Feb 11, 2022
Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Keiichiro Okamoto, Mana Hasegawa, Kajita Piriyaprasath, Yoshito Kakihara, Makio Saeki, Kensuke Yamamura

Japanese Dental Science Review, 57 231-241, Nov, 2021
Effects of rice fermented extracts, "Sake Lees", on the functional activity of odontoblast-like cells (KN-3 cells).

Keiichiro Okamoto, Yoshito Kakihara, Naoto Ohkura, Aiko Tohma, Ayako Washio, Chiaki Kitamura, Yuichiro Noiri, Kensuke Yamamura, Makio Saeki

Odontology, 110(2) 254-261, Sep 8, 2021
メカニカルストレス下における歯根膜細胞外基質タンパクのプロテオーム解析

Thant Lay, 加来賢, 柿原嘉人, 水越優, 北見恩美, 北見公平, 小林大記, 吉田豊, 魚島勝美, 齋藤功 …

日本結合組織学会学術大会プログラム・抄録集, 53回 137-137, Jun, 2021
HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma

Akihiko Nakamura, Yoshito Kakihara, Akinori Funayama, Kenta Haga, Toshihiko Mikami, Daiki Kobayashi, Yutaka Yoshida, Kenji Izumi, Tadaharu Kobayashi, Makio Saeki

Biochemical and Biophysical Research Communications, 557 294-301, Jun, 2021
Identification and characterization of R2TP in the development of oral squamous cell carcinoma

Tetsuo Kiguchi, Yoshito Kakihara, Manabu Yamazaki, Kouji Katsura, Kenji Izumi, Jun-ichi Tanuma, Takashi Saku, Ritsuo Takagi, Makio Saeki

Biochemical and Biophysical Research Communications, 548 161-166, Apr, 2021
HEATR1はPontin/Reptinを安定化させmTORシグナル経路を介してOSCC細胞の増殖を正に制御する

中村彬彦, 柿原嘉人, 船山昭典, 小林正治, 佐伯万騎男

新潟歯学会雑誌, 50(2) 111-111, Dec, 2020
Reptinは胎仔上皮におけるDNA損傷応答を介して器官形成を制御する

目黒史也, 柿原嘉人, 川崎真依子, 川崎勝盛, 丹原惇, トゥラカナン・スッパラック, 工藤武久, 山田茜, 前田健康, 多部田康一 …

新潟歯学会雑誌, 50(2) 115-116, Dec, 2020
R2TP/PAQosome as a promising chemotherapeutic target in cancer.

Yoshito Kakihara, Tetsuo Kiguchi, Atsushi Ohazama, Makio Saeki

The Japanese dental science review, 56(1) 38-42, Dec, 2020 Peer-reviewed
IFT20 is critical for collagen biosynthesis in craniofacial bone formation.

Hiroyuki Yamaguchi, Masahiko Terajima, Megumi Kitami, Jianbo Wang, Li He, Makio Saeki, Mitsuo Yamauchi, Yoshihiro Komatsu

Biochemical and biophysical research communications, Sep 26, 2020
リボソーム合成関連因子HEATR1は、Pontin/Reptin complexと共に口腔扁平上皮癌進展に寄与する

中村彬彦, 木口哲郎, 高木律男, 船山昭典, 小林正治, 柿原嘉人, 佐伯万騎男

日本口腔科学会雑誌, 69(2) 132-132, Jul, 2020
リボソーム合成関連因子HEATR1は、Pontin/Reptin complexと共に口腔扁平上皮癌進展に寄与する

中村彬彦, 木口哲郎, 高木律男, 船山昭典, 小林正治, 柿原嘉人, 佐伯万騎男

日本口腔科学会雑誌, 69(2) 132-132, Jul, 2020
ROCK inhibitors enhance bone healing by promoting osteoclastic and osteoblastic differentiation.

Juri Nakata, Yosuke Akiba, Jun Nihara, Lay Thant, Kaori Eguchi, Hiroko Kato, Kenji Izumi, Mariko Ohkura, Masanori Otake, Yoshito Kakihara …

Biochemical and biophysical research communications, Mar 17, 2020 Peer-reviewed
Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.

Yurie Yamada, Supaluk Trakanant, Jun Nihara, Takehisa Kudo, Kenji Seo, Makio Saeki, Masayuki Kurose, Daisuke Matsumaru, Takeyasu Maeda, Atsushi Ohazama

Neuroscience, 432 229-239, Feb 28, 2020 Peer-reviewed
Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats.

Shimizu S, Nakatani Y, Kakihara Y, Taiyoji M, Saeki M, Takagi R, Yamamura K, Okamoto K

Bioscience, Biotechnology, and Biochemistry, 84(1) 159-170, Jan, 2020 Peer-reviewed
口腔扁平上皮癌における新規分子シャペロンR2TPの機能解析

柿原嘉人, 木口哲郎, 高木律男, 佐伯万騎男

有病者歯科医療, 28(6) 424-424, Dec, 2019
Pontin-Reptin complexは、リボソーム合成関連因子HEATR1を安定化することで口腔扁平上皮癌進展に寄与する

中村彬彦, 木口哲郎, 船山昭典, 柿原嘉人, 佐伯万騎男

Journal of Oral Biosciences Supplement, 2019 161-161, Oct, 2019
Bmp signaling in molar cusp formation.

Fumiya Meguro, Thantrira Porntaveetus, Maiko Kawasaki, Katsushige Kawasaki, Akane Yamada, Yoshito Kakihara, Makio Saeki, Koichi Tabeta, John A Kessler, Takeyasu Maeda …

Gene expression patterns : GEP, 32 67-71, Jun, 2019 Peer-reviewed
口腔扁平上皮癌における新規分子シャペロンR2TPの機能解析

柿原嘉人, 木口哲郎, 高木律男, 佐伯万騎男

歯科薬物療法, 38(2) 121-121, Mar, 2019

Research Projects

低酸素微小環境を標的としたコルジセピン誘導体による口腔がん治療の検討

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

佐伯万騎男, 柿原嘉人, 小林正治
口腔扁平上皮癌におけるR2TPのターゲット解析と治療標的としての可能性の検討

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

柿原嘉人, 佐伯万騎男, 荒井雅吉, 船山昭典
Elucidation of mechanism on congenital abnormality in the maxillofacial region focusing on DNA repair mechanism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

MAEDA TAKEYASU
Elucidation of fate path and regulatory factors of periodontal ligament tissue stem cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Masaru Kaku
Challenges to development of "bioregenerative therapy"

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2020

Ohazama Atsushi
Analysis of the molecular mechanism of the mechanical stress response in osteoblasts through primary cilia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Kakihara Yoshito
Study for elucidating indiction mechanism of stem cells by manipulation molecule

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Ohazama Atsushi
難治性口腔扁平上皮癌におけるセツキシマブ耐性ループ仮説の検証

基盤C, 2018 - 2020

佐伯万騎男
Golgi-localized Fam20C phosphorylation and osteocyte functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Toyosawa Satoru, SAEKI MAKIO, SATO SUNAO, USAMI YU
Establishment of iPS cell-based bone tissue engineering using small molecule compounds

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Egusa Hiroshi, YATANI Hirofumi, MATSUMOTO Takuya, SAEKI Makio
Development of the new method to control the resorption of alveolar bone, targeting receptor acting on bone - nervous system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

YATANI HIROFUMI, EGUSA Hiroshi
Role of Monad-interacting complex on tumorigenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SAEKI Makio
Ultramicrostructural analysis of biomineralization processes of DMP1

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

TOYOSAWA Satoru, YASUDA Hidehiro, MIURA Ichirou, ISHIMOTO Takuya, SAEKI Makio, USA Yu, KAGAWA Ryousuke
Reguratiion for invasion of OSCC by reptin

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

NAKAHARA Hirokazu
Trial research of fibrous dysplasia model transplanted with GNAS1 mutant cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2012

TOYOSAWA Satoru, SAEKI Makio, SATO Jun, USAMI Yu
Development of cell-based screening system for identifying osteogenesis-targeting compounds

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2010 - 2012

YATANI Hirofumi, EGUSA Hiroshi, SAEKI Makio, FUKUYASU Sho
Analysis of bone regeneration using small-molecule harmine and Id2-knockout mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011

EGUSA Hiroshi, YATANI Hirofumi, SAEKI Makio, YOKOTA Yoshifumi
Elucidation of the mechanism of biomineralization with acidic phosphoprotein from molecular evolution studies

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

TOYOSAWA Satoru, NAKANO Takayoshi, SAEKI Makio, SATO Sunao, KISHINO Mitunobu, KAGAWA Ryousuke
Therapeutic strategies against bone resorption using calcineurin signaling in osteoclast

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

SAEKI Makio, KAMISAKI Yoshinori
Investigation for apoptosis regulation system of Monad and its application on therapy of oral tumors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

KAMISAKI Yoshinori, WADA Koichiro, SAEKI Makio, NAKAHARA Hirokazu

Research Interests

Research Areas

Life sciences / Oral medicine / 歯科薬理学

Research History

Education

- 1995

Faculty of Dentistry, Osaka University
- 1995

School of Dentistry, Osaka University

Misc.

Reptinは胎仔上皮におけるDNA損傷応答を介して器官形成を制御する

目黒史也, 目黒史也, 目黒史也, 柿原嘉人, 川崎真依子, 川崎勝盛, 川崎勝盛, 丹原惇, 丹原惇, トゥラカナンスッパラック …

新潟歯学会雑誌, 50(2), 2020
日本酒によるストレス誘発性の咬筋侵害応答の軽減効果は日本酒含有エタノールの直接作用ではない

中谷暢佑, 柿原嘉人, 清水志保, 黒瀬雅之, 佐伯万騎男, 高木律男, 山村健介, 岡本圭一郎

Journal of Oral Biosciences Supplement, 2018 260-260, Sep, 2018
ROCK阻害剤の骨代謝および矯正学的歯の移動への影響

中田樹里, 柿原嘉人, 秋葉陽介, 江口香里, 丹原惇, 大倉麻里子, 加藤寛子, 泉健次, 佐伯万騎男, 齋藤功

新潟歯学会雑誌, 47(2) 120-120, Dec, 2017
ROCK阻害剤による骨形成促進メカニズムの解析

中田樹里, 柿原嘉人, 丹原惇, 佐伯万騎男, 齋藤功

日本矯正歯科学会大会プログラム・抄録集, 76回 184-184, Oct, 2017
分子シャペロンR2TPの口腔扁平上皮癌進展における作用機序の解析

木口哲郎, 柿原嘉人, 山崎学, 高木律男, 佐伯万騎男

Journal of Oral Biosciences Supplement, 2017 256-256, Sep, 2017
『酒は百薬の長』の根拠を科学的に解明するストレス誘発性の咬筋侵害受容反応に対する日本酒の影響について

岡本圭一郎, 中谷暢佑, 黒瀬雅之, 柿原嘉人, 木口哲郎, 長谷川真奈, 藤井規孝, 佐伯万騎男, 高木律男, 山村健介

Journal of Oral Biosciences Supplement, 2017 462-462, Sep, 2017
セロトニン再取り込み阻害薬は繰り返しストレスによる咬筋の侵害受容反応の増強を抑制する

中谷暢佑, 黒瀬雅之, 清水志保, 柿原嘉人, 木口哲郎, 長谷川真奈, 佐伯万騎男, 高木律男, 山村健介, 岡本圭一郎

Journal of Oral Biosciences Supplement, 2017 463-463, Sep, 2017
ROCK阻害剤の骨代謝への影響とその作用機序の解析

中田樹里, 秋葉陽介, 江口香里, 丹原惇, 齋藤功, 柿原嘉人, 佐伯万騎男

日本骨代謝学会学術集会プログラム抄録集, 35回 184-184, Jul, 2017
破骨細胞分化に影響を与える薬剤のスクリーニングとその作用機序の解析

中田樹里, 柿原嘉人, 秋葉陽介, 丹原惇, 齋藤功, 佐伯万騎男

日本骨代謝学会学術集会プログラム抄録集, 34回 207-207, Jul, 2016
リボソーム合成制御因子R2TPの口腔扁平上皮癌進展における作用機序の解析

木口哲郎, 木口哲郎, 柿原嘉人, 山崎学, 永田昌毅, 高木律男, 佐伯万騎男

日本薬理学会北部会プログラム・抄録集, 67th 64, 2016
破骨細胞の分化を誘導する小分子化合物の探索

西川実沙, 柿原嘉人, 秋葉陽介, 江草宏, 佐伯万騎男

Journal of Oral Biosciences Supplement, 2015 546-546, Sep, 2015
破骨細胞分化に影響を与える薬剤の探索

中田樹里, 柿原嘉人, 丹原惇, 齋藤功, 江草宏, 佐伯万騎男

日本骨代謝学会学術集会プログラム抄録集, 33回 196-196, Jul, 2015
破骨細胞の分化を誘導する小分子化合物の探索

西川実沙, 柿原嘉人, 秋葉陽介, 江草宏, 佐伯万騎男

Journal of Oral Biosciences Supplement (Web), 2015, 2015
破骨細胞分化に影響を与える薬剤のケミカルライブラリースクリーニング

中田樹里, 中田樹里, 柿原嘉人, 秋葉陽介, 丹原惇, 齋藤功, 江草宏, 佐伯万騎男

日本薬理学会北部会プログラム・抄録集, 66th 53, 2015
PICK1 Regulates Osteoclastogenesis by Binding to Calcineurin B

Yuya Kamano, Makio Saeki, Hiroshi Egusa, Hirofumi Yatani, Yoshinori Kamisaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 93P-93P, 2014
Monad regulates stability of Amphiregulin mRNA

Kyoko Kurioka, Makio Saeki, Yasuyuki Irie, Yoshinori Kamisaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 213P-213P, 2012
Monad binding protein-2 interacts with RPAP3 and regulates doxorubicin-induced apoptosis in U2OS cell

Mika Inoue, Kana Horiuchi, Makio Saeki, Hiroshi Egusa, Hitoshi Niwa, Yoshinori Kamisaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 58P-58P, 2010
RPAP3 promotes doxorubicin-induced apoptosis in human breast cancer T-47D cells

Kana Horiuchi, Mika Inoue, Makio Saeki, Hiroshi Egusa, Yoshiaki Yura, Yoshinori Kamisaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 113P-113P, 2010
Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains

Yuki Itsuki, Makio Saeki, Hirokazu Nakahara, Hiroshi Egusa, Yasuyuki Irie, Yutaka Terao, Shigetada Kawabata, Hirofumi Yatani, Yoshinori Kamisaki

FEBS LETTERS, 582(16) 2365-2370, Jul, 2008
Involvement of calcineurin in osteoclastogenesis mediated by RANKL

Tsutomu Iida, Hiroshi Egusa, Makio Saeki, Masanori Doi, Hirofumi Yatani, Yoshinori Kamisaki

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 154P-154P, 2008

Profile Information

Papers

Research Projects

Research Interests

Research Areas

Research History

Education

Misc.

Professional Memberships

Menu

Coauthors