2011年1月
Structure of the inhibitor complex of old yellow enzyme from Trypanosoma cruzi
JOURNAL OF SYNCHROTRON RADIATION
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 18
- 号
- 開始ページ
- 66
- 終了ページ
- 69
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1107/S0909049510033595
- 出版者・発行元
- WILEY-BLACKWELL
Old yellow enzyme (OYE) is an NADPH oxidoreductase which contains flavin mononucleotide as prosthetic group. The X-ray structures of OYE from Trypanosoma cruzi (TcOYE) which produces prostaglandin (PG) F-2 alpha from PGH(2) have been determined in the presence or absence of menadione. The binding motif of menadione, known as one of the inhibitors for TcOYE, should accelerate the structure-based development of novel anti-chagasic drugs that inhibit PGF(2 alpha) production specifically.
- リンク情報
- ID情報
-
- DOI : 10.1107/S0909049510033595
- ISSN : 0909-0495
- Web of Science ID : WOS:000285409000017