J-GLOBAL         Last updated: Jul 2, 2019 at 02:42
Gifu University
Faculty of Engineering
Ph.D.(Gifu Pharmaceutical University), Master of Pharmaceutical Sciences(Gifu Pharmaceutical University)

Research Interests


Research Areas


Academic & Professional Experience

Gifu University Faculty of Engineering, Department of Biomolecular Science, Laboratory of Molecular Biochemistry
Gifu Pharmaceutical University, Research Assistant
Gifu University, Associate Professor
- Gifu University, Professor


Graduate School, Division of Pharmaceutical Sciences, Gifu Pharmaceutical University
Faculty of Pharmaceutical Science, Gifu Pharmaceutical University


Yoshio Kusakabe, Masaaki Ishihara, Tomonobu Umeda, Daisuke Kuroda, Masayuki Nakanishi, Yukio Kitade, Hiroaki Gouda, Kazuo T. Nakamura, Nobutada Tanaka
Scientific Reports   5    Nov 2015
© 2015, Nature Publishing Group. All rights reserved. S-adenosyl-L-homocysteine hydrolase (SAH hydrolase or SAHH) is a highly conserved enzyme that catalyses the reversible hydrolysis of SAH to L-homocysteine (HCY) and adenosine (ADO). High-resolu...
Yuki Nagaya, Yoshiaki Kitamura, Yoshiaki Kitamura, Remi Nakashima, Aya Shibata, Aya Shibata, Masato Ikeda, Masato Ikeda, Masato Ikeda, Yukio Kitade, Yukio Kitade, Yukio Kitade
Nucleosides, Nucleotides and Nucleic Acids   35 64-75   Jan 2016
© 2016 Taylor & Francis Group, LLC. We developed a practical and reliable method for synthesizing an abasic deoxyribonucleoside, 1,2-dideoxy-D-ribofuranose (dRH) via elimination of nucleobase from thymidine. To synthesize oligonucleotides bearing ...
Masato Ikeda, Masato Ikeda, Masato Ikeda, Keito Horio, Tomoya Tsuzuki, Ryo Torii, Aya Shibata, Aya Shibata, Yoshiaki Kitamura, Yoshiaki Kitamura, Hiroshi Katagiri, Yukio Kitade, Yukio Kitade, Yukio Kitade
Tetrahedron Letters      Aug 2015
© 2015 Elsevier Ltd. Herein, we describe a new methodology for the solid phase submonomer synthesis (SPSS) of arylopeptoids using a reductive amination reaction as the key step instead of a nucleophilic substitution reaction, which is generally us...
Satoshi Endo, Misato Noda, Akira Ikari, Kenjiro Tatematsu, Ossama El-Kabbani, Akira Hara, Yukio Kitade, Toshiyuki Matsunaga
Journal of Biochemistry   158 425-434   Feb 2015
© The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved. The cDNAs for morphine 6-dehydrogenase (AKR1C34) and its homologous aldo-keto reductase (AKR1C35) were cloned from golden ...
Satoshi Endo, Toshiyuki Matsunaga, Akira Ikari, Ossama El-Kabbani, Akira Hara, Yukio Kitade
Archives of Biochemistry and Biophysics   569 19-25   Mar 2015
© 2015 Elsevier Inc. In rabbit tissues, hydroxysteroid dehydrogenase belonging to the aldo-keto reductase (AKR) superfamily exists in six isoforms (AKRs: 1C5 and 1C29-1C33), sharing >73% amino acid sequence identity. AKR1C33 is strictly NADPH-spec...

Books etc

Facile Preparation of Sequence-Specific 2', 5'-Oligonucleotides
Nucleic Acid Chemistry, Improved and New Synthetic Procedure, Methods and Techniques, Part4, John Wiley & Sons, Inc.   1991   

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2004    Investigator(s): Yukio KITADE
1.8-Methyladenosine-substituted 2-5A tetramers with hydroxyalkyl groups at the 5'-phosphates and the corresponding chimeras were synthesized by the phosphoramidite method with a DNA/RNA synthesizer. Incorporation of the hydroxyethyl group into 2-5...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2002    Investigator(s): Yukio KITADE
Antisense oligonucleotides have been applied extensively for the regulation of cellular and viral gene expression. They hybridize to mRNA targets through Watson-Crick base-pairing and inhibit the translation of mRNA in a sequence-specific manner. ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Yukio KITADE
The cellular enzyme S-adenosyl-L-homocysteine (SAH) hydrolase (EC has emerged as a target enzyme for the molecular design of anti-viral agents. During the course of studies on the preparation of biologically important nucleosides using th...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1994 - 1995    Investigator(s): Yukio KITADE
Reaction of purine nucleosides with diisobutylaluminum hydride (DIBAL-H) in dry tetrahydrofurane resulted in the reductive cleavage of the ribose moiety at the anomeric position to give the corresponding 9-ribitylpurines in good yeilds. Taking int...
Study on Oligoadenylates as potential antiviral agents