Jul, 2005
Dopamine agonist pergolide prevents levodopa-induced quinoprotein formation in Parkinsonian striatum and shows quenching effects on dopamine-semiquinone generated in vitro
Clinical Neuropharmacology
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- Volume
- 28
- Number
- 4
- First page
- 155
- Last page
- 160
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1097/01.wnf.0000175523.33334.24
The neurotoxicity of dopamine (DA) quinones that appears in dopaminergic neuron-specific oxidative stress has recently been shown to play a role in the pathogenesis and/or progression of Parkinson disease. To clarify the effects of a DA agonist, pergolide, on the levodopa-induced elevation of quinones, the authors examined, striatal changes in quinoprotein using a hemi-parkinsonian mouse model. The level of striatal quinoprotein was significantly elevated specifically on the parkinsonian side, but not on the control side, after repeated levodopa administration. This levodopa-induced increase in striatal quinoprotein was almost completely suppressed by adjunctive administration with pergolide on the lesioned side. Furthermore, it was clarified that pergolide scavenged DA-semiquinones generated in vitro in a dose-dependent manner. These suppressive and quenching effects of pergolide against cytotoxic DA quinones may play a key role in its neuroprotective mechanism in the parkinsonian brain. Copyright © 2005 by Lippincott Williams &
Wilkins.
Wilkins.
- Link information
- ID information
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- DOI : 10.1097/01.wnf.0000175523.33334.24
- ISSN : 0362-5664
- Pubmed ID : 16062092
- SCOPUS ID : 23644452346