1995年11月
High DNA-binding activity of transcription factor NF-κB in synovial membranes of patients with rheumatoid arthritis.
Biochemistry and Molecular Biology International
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- 巻
- 37
- 号
- 5
- 開始ページ
- 827
- 終了ページ
- 832
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- ACADEMIC PRESS AUST
Our objective was to clarify the DNA-binding activity of transcription factor NF-kappa B as related to cytokine induction in the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Synovial membranes were obtained during arthroplasty of the knee from 7 patients with RA and 4 patients with OA. Nuclear extracts obtained from the synovial membranes were examined by electrophoretic mobility shift assay to determine the DNA-binding activity of NF-kappa B. Markedly high DNA-binding activity of NF-kappa B was detected in the synovial membranes of RA patients, while virtually no activity was observed in those of OA patients. These results suggest that the high induction of NF-kappa B in the nuclear extracts may be relatively specific to synovial membranes in RA. NF-kappa B may regulate the production of cytokines at the site of synovial inflammation.
- リンク情報
- ID情報
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- ISSN : 1039-9712
- Web of Science ID : WOS:A1995VG87600003