Papers

Peer-reviewed Lead author Corresponding author
May, 2008

Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease

Current Pharmacutical Design
  • Masato Asanuma
  • ,
  • Ikuko Miyazaki

Volume
14
Number
14
First page
1428
Last page
1434
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.2174/138161208784480153
Publisher
BENTHAM SCIENCE PUBL LTD

A number of experimental studies using parkinsonian models have revealed that nonsteroidal anti-inflammatory drugs (NSAIDs) have neuroprotective properties against dopaminergic neurotoxicity not only by their cyclooxygenase-inhibiting effect but also by other specific properties or some unknown pharmacological effects. This article reviews heterogeneous pharmacological properties of NSAIDs including inhibitory effect against nitric oxide synthesis, agonistic action for peroxisome proliferator-activated receptor or possible suppressive effects against dopamine quinone generation, and also reviews their neuroprotective effects in the experimental parkinsonian models and pathogenesis of Parkinson's disease. Several epidemiological studies recently clarified that the use of nonaspirin NSAIDs but not aspirin was associated with a lower prevalence of Parkinson's disease, in contrast with neuroprotective effects of aspirin in the experimental studies. It also discusses the discrepancy between results in the experimental parkinsonian models and epidemiological data in prevalence of Parkinson's disease on the effects of NSAIDs.

Link information
DOI
https://doi.org/10.2174/138161208784480153
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000256618300009&DestApp=WOS_CPL
ID information
  • DOI : 10.2174/138161208784480153
  • ISSN : 1381-6128
  • Web of Science ID : WOS:000256618300009

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