TAKASHIBA Shogo

Last updated: Nov 22, 2018 at 16:06

Name	TAKASHIBA Shogo
Affiliation	Okayama University
Degree	D.D.S.(Okayama University), Ph.D.(Okayama University)

Research Interests

Endodontology(30) , Periodontology(105) , Dentistry(51) , Periodontal Science (Periodontology & Endodontology)(1)

Research Areas

Dentistry / Conservative dentistry /
Dentistry / Periodontal dentistry /

Academic & Professional Experience

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Apr 2005

Today

Professor, Okayama University (Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Periodontal Science)

Apr 2002

Mar 2005

Professor, Okayama University (Graduate School of Medicine and Dentistry, Periodontal Science)

Apr 2001

Mar 2002

Associate Professor, Okayama University (Graduate School of Medicine and Dentistry, Periodontal Science)

Nov 1995

Mar 2001

Associate Professor, Okayama University (Dental School, Periodontology & Endodontology)

Dec 1994

Nov 1995

Assistant Professor, Okayama University (Dental School, Periodontology & Endodontology)

Education

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Apr 1986

Mar 1990

Periodontology and Endodontology, Graduate School of Dentistry, Okayama University

1990

Graduate School, Division of Dental Research, Okayama University

Apr 1980

Feb 1986

Dentistry, Dental School, Okayama University

1986

Faculty of Dentistry, Okayama University

Awards & Honors

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1997

Hatton Awards Nominee Division Travel Award

Published Papers

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Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study.

Kudo C, Shin WS, Sasaki N, Harai K, Kato K, Seino H, Goke E, Fujino T, Kuribayashi N, Pearce YO, Taira M, Matsushima R, Minabe M, Takashiba S, Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums.

Odontology 106(3) 316-327 Jul 2018 [Refereed]

HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket.

Aoyagi H, Yamashiro K, Hirata-Yoshihara C, Ideguchi H, Yamasaki M, Kawamura M, Yamamoto T, Kochi S, Wake H, Nishibori M, Takashiba S

Journal of cellular biochemistry 119(7) 5481-5490 Jul 2018 [Refereed]

Correction to: Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study.

Odontology 106(3) 349 Jul 2018 [Refereed]

Molecular imaging assessment of periodontitis lesions in an experimental mouse model.

Ideguchi H, Yamashiro K, Yamamoto T, Shimoe M, Hongo S, Kochi S, Yoshihara-Hirata C, Aoyagi H, Kawamura M, Takashiba S

Clinical oral investigations Jun 2018 [Refereed]

Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model.

Yoshihara-Hirata C, Yamashiro K, Yamamoto T, Aoyagi H, Ideguchi H, Kawamura M, Suzuki R, Ono M, Wake H, Nishibori M, Takashiba S

Infection and immunity 86(5) May 2018 [Refereed]

Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells.

Senoo K, Yamashiro K, Yamamoto T, Myokai F, Kawamura M, Takashiba S

Odontology 106(2) 135-144 Apr 2018 [Refereed]

Correction to: Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells.

Senoo K, Yamashiro K, Yamamoto T, Myokai F, Kawamura M, Takashiba S

Odontology 106(2) 223 Apr 2018 [Refereed]

Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics.

Yamamoto T, Ugawa Y, Kawamura M, Yamashiro K, Kochi S, Ideguchi H, Takashiba S

Journal of cell communication and signaling 12(1) 369-378 Mar 2018 [Refereed]

The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study.

Kobayashi T, Kido JI, Ishihara Y, Omori K, Ito S, Matsuura T, Bando T, Wada J, Murasawa A, Nakazono K, Mitani A, Takashiba S, Nagata T, Yoshie H

Journal of periodontology 89(3) 315-324 Mar 2018 [Refereed]

Effects of Lectins on initial attachment of cariogenic Streptococcus mutans.

Ito T, Yoshida Y, Shiota Y, Ito Y, Yamamoto T, Takashiba S

Glycoconjugate journal 35(1) 41-51 Feb 2018 [Refereed]

Effects of Mechanical Stress on Periodontal Ligament

Fujita Ayano, Morimatsu Masatoshi, Nishiyama Masayoshi, Takashiba Shogo, Naruse Keiji

BIOPHYSICAL JOURNAL 114(3) 143A Feb 2018 [Refereed]

IS1598 (IsPg4) distributed to abscess-forming strains of Porphyromonas gingivalis may enhance virulence through upregulation of nrdD-like gene expression.

Sonoi N, Maeda H, Murauchi T, Yamamoto T, Omori K, Kokeguchi S, Naruishi K, Takashiba S

The new microbiologica 41(1) 52-60 Jan 2018 [Refereed]

Histological and immunohistochemical features of gingival enlargement in a patient with AML.

Sonoi N, Soga Y, Maeda H, Ichimura K, Yoshino T, Aoyama K, Fujii N, Maeda Y, Tanimoto M, Logan R, Raber-Durlacher J, Takashiba S

Odontology / the Society of the Nippon Dental University 100(2) 254-257 Jul 2012 [Refereed]

Involvement of an Skp-Like Protein, PGN_0300, in the Type IX Secretion System of Porphyromonas gingivalis.

Taguchi Y, Sato K, Yukitake H, Inoue T, Nakayama M, Naito M, Kondo Y, Kano K, Hoshino T, Nakayama K, Takashiba S, Ohara N

Infection and immunity 84(1) 230-240 Jan 2016 [Refereed]

With regard to our manuscripts on the commercial saliva substitute, Oralbalance®--its formula has been changed.

Sugiura Y, Soga Y, Tanimoto I, Kokeguchi S, Morishige-Nishide S, Itami-Kono K, Takahashi K, Fujii N, Ishimaru F, Tanimoto M, Yamabe K, Tsutani S, Nishimura F, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 22(12) 3121-3122 Dec 2014 [Refereed]

Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.

Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, Mitsudo K, Ibaragi S, Sasaki A, Maeda H, Takashiba S, Suga S

Bioorganic & medicinal chemistry 22(19) 5338-5344 Oct 2014 [Refereed]

Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation.

Soga Y, Maeda Y, Ishimaru F, Tanimoto M, Maeda H, Nishimura F, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 19(7) 995-1000 Jul 2011 [Refereed]

Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation.

Ebinuma T, Soga Y, Sato T, Matsunaga K, Kudo C, Maeda H, Maeda Y, Tanimoto M, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 22(6) 1679-1683 Jun 2014 [Refereed]

Specific in situ visualization of plasma cells producing antibodies against Porphyromonas gingivalis in gingival radicular cyst: application of the enzyme-labeled antigen method.

Tsuge S, Mizutani Y, Matsuoka K, Sawasaki T, Endo Y, Naruishi K, Maeda H, Takashiba S, Shiogama K, Inada K, Tsutsumi Y

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 59(7) 673-689 Jul 2011 [Refereed]

Effect of Porphyromonas gingivalis outer membrane vesicles on gingipain-mediated detachment of cultured oral epithelial cells and immune responses.

Nakao R, Takashiba S, Kosono S, Yoshida M, Watanabe H, Ohnishi M, Senpuku H

Microbes and infection 16(1) 6-16 Jan 2014 [Refereed]

Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.

Hirai K, Maeda H, Omori K, Yamamoto T, Kokeguchi S, Takashiba S

Pathogens and disease 68(1) 12-19 Jun 2013 [Refereed]

Cytokine expression in human dermal fibroblasts stimulated with eosinophil cationic protein measured by protein array.

Sato T, Soga Y, Yamaguchi T, Meguro M, Maeda H, Tada J, Otani T, Seno M, Takashiba S

Asian Pacific journal of allergy and immunology 31(4) 271-276 Dec 2013 [Refereed]

Antibiotic sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation.

Soga Y, Maeda Y, Tanimoto M, Ebinuma T, Maeda H, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 21 367-368 Feb 2013 [Refereed]

Prognosis of periodontitis recurrence after intensive periodontal treatment using examination of serum IgG antibody titer against periodontal bacteria.

Sugi N, Naruishi K, Kudo C, Hisaeda-Kako A, Kono T, Maeda H, Takashiba S

Journal of clinical laboratory analysis 25(1) 25-32 2011 [Refereed]

Assessment of the plasma/serum IgG test to screen for periodontitis.

Kudo C, Naruishi K, Maeda H, Abiko Y, Hino T, Iwata M, Mitsuhashi C, Murakami S, Nagasawa T, Nagata T, Yoneda S, Nomura Y, Noguchi T, Numabe Y, Ogata Y, Sato T, Shimauchi H, Yamazaki K, Yoshimura A, Takashiba S

Journal of dental research 91(12) 1190-1195 Dec 2012 [Refereed]

Outer membrane vesicles of Porphyromonas gingivalis elicit a mucosal immune response.

Nakao R, Hasegawa H, Ochiai K, Takashiba S, Ainai A, Ohnishi M, Watanabe H, Senpuku H

PloS one 6(10) e26163 Oct 2011 [Refereed]

Smad2 decelerates re-epithelialization during gingival wound healing.

Tomikawa K, Yamamoto T, Shiomi N, Shimoe M, Hongo S, Yamashiro K, Yamaguchi T, Maeda H, Takashiba S

Journal of dental research 91(8) 764-770 Aug 2012 [Refereed]

Influence of resin coating materials on Porphyromonas gingivalis attachment.

Kumada A, Matsuka Y, Mine A, Ono M, Uehara J, Sonoi N, Ito T, Takashiba S, Kuboki T

Dental materials journal 31(1) 86-91 Feb 2012 [Refereed]

Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease.

Takahashi T, Muro S, Tanabe N, Terada K, Kiyokawa H, Sato S, Hoshino Y, Ogawa E, Uno K, Naruishi K, Takashiba S, Mishima M

PloS one 7 e40570 2012 [Refereed]

Progress of oral care and reduction of oral mucositis--a pilot study in a hematopoietic stem cell transplantation ward.

Soga Y, Sugiura Y, Takahashi K, Nishimoto H, Maeda Y, Tanimoto M, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 19(2) 303-307 Feb 2010 [Refereed]

Chronic periodontitis with multiple risk factor syndrome: a case report.

Shimoe M, Yamamoto T, Iwamoto Y, Shiomi N, Maeda H, Nishimura F, Takashiba S

Journal of the International Academy of Periodontology 13 40-47 Jul 2011 [Refereed]

Discovery of a patient with strongly suspected bullous pemphigoid in a ward by oral health care providers.

Kanda N, Soga Y, Meguro M, Tanabe A, Yagi Y, Himuro Y, Fujiwara Y, Takashiba S, Kobayashi N

International journal of dental hygiene 9 159-162 May 2011 [Refereed]

Immune responses to porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model.

Naruishi K, Omori K, Maeda H, Sonoi N, Funakoshi K, Hirai K, Ishii M, Kubo K, Kobayashi H, Tomiyama T, Yamamoto D, Tanimoto I, Kunimatsu K, Takashiba S

Journal of biological regulators and homeostatic agents 25 195-202 Apr 2011 [Refereed]

FGF-2 stimulates periodontal regeneration: results of a multi-center randomized clinical trial.

Kitamura M, Akamatsu M, Machigashira M, Hara Y, Sakagami R, Hirofuji T, Hamachi T, Maeda K, Yokota M, Kido J, Nagata T, Kurihara H, Takashiba S, Sibutani T, Fukuda M, Noguchi T, Yamazaki K, Yoshie H, Ioroi K, Arai T, Nakagawa T, Ito K, Oda S, Izumi Y, Ogata Y, Yamada S, Shimauchi H, Kunimatsu K, Kawanami M, Fujii T, Furuichi Y, Furuuchi T, Sasano T, Imai E, Omae M, Yamada S, Watanuki M, Murakami S

Journal of dental research 90 35-40 Jan 2011 [Refereed]

Clinical and immunological assessment of periodontal disease in Japanese leprosy patients.

Ohyama H, Hongyo H, Shimizu N, Shimizu Y, Nishimura F, Nakagawa M, Arai H, Kato-Kogoe N, Terada N, Nagai A, Takashiba S, Kurihara H, Nomura Y, Murayama Y

Japanese journal of infectious diseases 63 427-432 Nov 2010 [Refereed]

Rapid detection of mecA and spa by the loop-mediated isothermal amplification (LAMP) method.

Koide Y, Maeda H, Yamabe K, Naruishi K, Yamamoto T, Kokeguchi S, Takashiba S

Letters in applied microbiology 50(4) 386-392 Apr 2010 [Refereed]

Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT.

Yamabe K, Maeda H, Kokeguchi S, Soga Y, Meguro M, Naruishi K, Asakawa S, Takashiba S

Molecular oral microbiology 25 112-122 Apr 2010 [Refereed]

Highly expressed genes in a rough-colony-forming phenotype of Aggregatibacter actinomycetemcomitans: implication of a mip-like gene for the invasion of host tissue.

Maeda T, Maeda H, Yamabe K, Mineshiba J, Tanimoto I, Yamamoto T, Naruishi K, Kokeguchi S, Takashiba S

FEMS immunology and medical microbiology 58(2) 226-236 Mar 2010 [Refereed]

Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation.

Sugiura Y, Soga Y, Yamabe K, Tsutani S, Tanimoto I, Maeda H, Kokeguchi S, Fujii N, Ishimaru F, Tanimoto M, Nishimura F, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 18 395-398 Mar 2010 [Refereed]

Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen.

Takahashi K, Soga Y, Murayama Y, Udagawa M, Nishimoto H, Sugiura Y, Maeda Y, Tanimoto M, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 18 115-119 Jan 2010 [Refereed]

Genetic risk factors for periodontitis in a Japanese population.

Kobayashi T, Nagata T, Murakami S, Takashiba S, Kurihara H, Izumi Y, Numabe Y, Watanabe H, Kataoka M, Nagai A, Hayashi J, Ohyama H, Okamatsu Y, Inagaki Y, Tai H, Yoshie H

Journal of dental research 88 1137-1141 Dec 2009 [Refereed]

Porphyromonas gingivalis fimbriae-dependent interleukin-6 autocrine regulation by increase of gp130 in endothelial cells.

Ho YS, Lai MT, Liu SJ, Lin CT, Naruishi K, Takashiba S, Chou HH

Journal of periodontal research 44 550-556 Aug 2009 [Refereed]

Febrile neutropenia and periodontitis: lessons from a case periodontal treatment in the intervals between chemotherapy cycles for leukemia reduced febrile neutropenia.

Soga Y, Yamasuji Y, Kudo C, Matsuura-Yoshimoto K, Yamabe K, Sugiura Y, Maeda Y, Ishimaru F, Tanimoto M, Nishimura F, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 17 581-587 May 2009 [Refereed]

Appearance of multidrug-resistant opportunistic bacteria on the gingiva during leukemia treatment.

Soga Y, Saito T, Nishimura F, Ishimaru F, Mineshiba J, Mineshiba F, Takaya H, Sato H, Kudo C, Kokeguchi S, Fujii N, Tanimoto M, Takashiba S

Journal of periodontology 79(1) 181-186 Jan 2008 [Refereed]

Antibacterial effect of bactericide immobilized in resin matrix.

Namba N, Yoshida Y, Nagaoka N, Takashima S, Matsuura-Yoshimoto K, Maeda H, Van Meerbeek B, Suzuki K, Takashiba S

Dental materials : official publication of the Academy of Dental Materials 25 424-430 Apr 2009 [Refereed]

Assessment of chromosome 19 for genetic association in severe chronic periodontitis.

Tabeta K, Shimada Y, Tai H, Ishihara Y, Noguchi T, Soga Y, Takashiba S, Suzuki G, Kobayashi T, Oka A, Kobayashi T, Yamazaki K, Inoko H, Yoshie H

Journal of periodontology 80 663-671 Apr 2009 [Refereed]

Macrophage-adipocyte interaction: marked interleukin-6 production by lipopolysaccharide.

Yamashita A, Soga Y, Iwamoto Y, Yoshizawa S, Iwata H, Kokeguchi S, Takashiba S, Nishimura F

Obesity (Silver Spring, Md.) 15(11) 2549-2552 Nov 2007 [Refereed]

Human leukocyte histocompatibility antigen class II-induced cytokines from human gingival fibroblasts promote proliferation of human umbilical vein endothelial cells: potential association with enhanced angiogenesis in chronic periodontal inflammation.

Okada Y, Meguro M, Ohyama H, Yoshizawa S, Takeuchi-Hatanaka K, Kato N, Matsushita S, Takashiba S, Nishimura F

Journal of periodontal research 44(1) 103-109 Feb 2009 [Refereed]

IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.

Yamaguchi T, Naruishi K, Arai H, Nishimura F, Takashiba S

Journal of cellular physiology 217(2) 423-432 Nov 2008 [Refereed]

Evaluation of xerostomia in hematopoietic cell transplantation by a simple capacitance method device.

Sugiura Y, Soga Y, Nishide S, Kono K, Takahashi K, Fujii N, Ishimaru F, Tanimoto M, Nishimura F, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 16 1197-1200 Oct 2008 [Refereed]

Distribution of Archaea in Japanese patients with periodontitis and humoral immune response to the components.

Yamabe K, Maeda H, Kokeguchi S, Tanimoto I, Sonoi N, Asakawa S, Takashiba S

FEMS microbiology letters 287(1) 69-75 Oct 2008 [Refereed]

Rapid and simple detection of eight major periodontal pathogens by the loop-mediated isothermal amplification method.

Miyagawa J, Maeda H, Murauchi T, Kokeguchi S, Yamabe K, Tanimoto I, Nishimura F, Fukui K, Takashiba S

FEMS immunology and medical microbiology 53 314-321 Aug 2008 [Refereed]

Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial.

Kitamura M, Nakashima K, Kowashi Y, Fujii T, Shimauchi H, Sasano T, Furuuchi T, Fukuda M, Noguchi T, Shibutani T, Iwayama Y, Takashiba S, Kurihara H, Ninomiya M, Kido J, Nagata T, Hamachi T, Maeda K, Hara Y, Izumi Y, Hirofuji T, Imai E, Omae M, Watanuki M, Murakami S

PloS one 3 e2611 Jul 2008 [Refereed]

Antimicrobial effects of the saliva substitute, Oralbalance, against microorganisms from oral mucosa in the hematopoietic cell transplantation period.

Sugiura Y, Soga Y, Tanimoto I, Kokeguchi S, Nishide S, Kono K, Takahashi K, Fujii N, Ishimaru F, Tanimoto M, Yamabe K, Tsutani S, Nishimura F, Takashiba S

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 16 421-424 Apr 2008 [Refereed]

Cloning and characterization of lipopolysaccharide-induced tumor necrosis factor alpha factor promoter.

Shiomi N, Myokai F, Naruishi K, Oyaizu K, Senoo K, Yamaguchi T, Amar S, Takashiba S

FEMS immunology and medical microbiology 47(3) 360-368 Aug 2006 [Refereed]

Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population.

Takeuchi-Hatanaka K, Ohyama H, Nishimura F, Kato-Kogoe N, Soga Y, Matsushita S, Nakasho K, Yamanegi K, Yamada N, Terada N, Takashiba S

Journal of clinical periodontology 35 317-323 Apr 2008 [Refereed]

Anti-inflammatory effect of linear polarized infrared irradiation on interleukin-1beta-induced chemokine production in MH7A rheumatoid synovial cells.

Shibata Y, Ogura N, Yamashiro K, Takashiba S, Kondoh T, Miyazawa K, Matsui M, Abiko Y

Lasers in medical science 20(3-4) 109-113 Dec 2005 [Refereed]

Focal adhesion kinase mediates human leukocyte histocompatibility antigen class II-induced signaling in gingival fibroblasts.

Yoshizawa S, Meguro M, Ohyama H, Takeuchi-Hatanaka K, Matsushita S, Takashiba S, Nishimura F

Journal of periodontal research 42 572-579 Dec 2007 [Refereed]

Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells.

Mineshiba J, Myokai F, Mineshiba F, Matsuura K, Nishimura F, Takashiba S

FEMS immunology and medical microbiology 45(1) 37-44 Jul 2005 [Refereed]

cAMP-response element binding protein (CREB) regulates cyclosporine-A-mediated down-regulation of cathepsin B and L synthesis.

Omori K, Naruishi K, Yamaguchi T, Li SA, Yamaguchi-Morimoto M, Matsuura K, Arai H, Takei K, Takashiba S

Cell and tissue research 330 75-82 Oct 2007 [Refereed]

Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease.

Yamazaki K, Honda T, Domon H, Okui T, Kajita K, Amanuma R, Kudoh C, Takashiba S, Kokeguchi S, Nishimura F, Kodama M, Aizawa Y, Oda H

Clinical and experimental immunology 149 445-452 Sep 2007 [Refereed]

Periodontal treatment in severe aplastic anemia.

Oyaizu K, Mineshiba F, Mineshiba J, Takaya H, Nishimura F, Tanimoto I, Arai H, Takashiba S

Journal of periodontology 76(7) 1211-1216 Jul 2005 [Refereed]

Gene profiles during root canal treatment in experimental rat periapical lesions.

Martinez ZR, Naruishi K, Yamashiro K, Myokai F, Yamada T, Matsuura K, Namba N, Arai H, Sasaki J, Abiko Y, Takashiba S

Journal of endodontics 33 936-943 Aug 2007 [Refereed]

Oligonucleotide array analysis of cyclic tension-responsive genes in human periodontal ligament fibroblasts.

Yamashiro K, Myokai F, Hiratsuka K, Yamamoto T, Senoo K, Arai H, Nishimura F, Abiko Y, Takashiba S

The international journal of biochemistry & cell biology 39 910-921 2007 [Refereed]

High glucose up-regulates lipopolysaccharide-stimulated inflammatory cytokine production via c-jun N-terminal kinase in the monocytic cell line THP-1.

Iwata H, Soga Y, Meguro M, Yoshizawa S, Okada Y, Iwamoto Y, Yamashita A, Takashiba S, Nishimura F

Journal of endotoxin research 13 227-234 2007 [Refereed]

Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts.

Yamaguchi M, Naruishi K, Yamada-Naruishi H, Omori K, Nishimura F, Takashiba S

Journal of periodontal research 39(5) 320-326 Oct 2004 [Refereed]

Regression of pustulosis palmaris et plantaris by periodontal treatment in a subject with severe periodontitis.

Akazawa H, Nishimura F, Maeda H, Takashiba S, Mine A, Maekawa K, Kuboki T

International journal of dermatology 45 1420-1422 Dec 2006 [Refereed]

Thiazolidinedione (pioglitazone) blocks P-gingivalis- and F-nucleatum, but not E-coli, lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) production in adipocytes

Yamaguchi M, Nishimura F, Naruishi H, Soga Y, Kokeguchi S, Takashiba S

Journal of Dental Research 84(3) 240-244 2005 [Refereed]

Periodontal treatment in severe aplastic anemia

Oyaizu K, Mineshiba F, Mineshiba J, Takaya H, Nishimura F, Tanimoto I, Arai H, Takashiba S

Journal of Periodontology 76(7) 1211-1216 2005 [Refereed]

Isolation and expression of FIP-2 in wounded pulp of the rat

Oyama M, Myokai F, Ohira T, Shiomi N, Yamashiro K, Arai H, Nishimura F, Takashiba S

Journal of Dental Research 84(9) 842-847 2005 [Refereed]

alpha 2 integrin+807 polymorphism in drug-induced gingival overgrowth

Ogino M, Kido J, Bando M, Hayashi N, Wada C, Nagata T, Nishimura F, Soga Y, Takashiba S, Kubota T, Itagaki M, Shimada Y, Tai H, Yoshie H, Yamazaki N, Shinohara Y, Kataoka M

Journal of Dental Research 84(12) 1183-1186 2005 [Refereed]

Gene polymorphisms in periodontal health and disease.

Takashiba S, Naruishi K

Periodontology 2000 40 94-106 2006 [Refereed]

Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth.

Ogino M, Kido J, Bando M, Hayashi N, Wada C, Nagata T, Nishimura F, Soga Y, Takashiba S, Kubota T, Itagaki M, Shimada Y, Tai H, Yoshie H, Yamazaki N, Shinohara Y, Kataoka M

Journal of dental research 84 1183-1186 Dec 2005 [Refereed]

Isolation and expression of FIP-2 in wounded pulp of the rat.

Oyama M, Myokai F, Ohira T, Shiomi N, Yamashiro K, Arai H, Nishimura F, Takashiba S

Journal of dental research 84 842-847 Sep 2005 [Refereed]

Identification of genes differentially regulated in rat alveolar bone wound healing by subtractive hybridization

Ohira T, Myokai F, Shiomi N, Yamashiro K, Yamamoto T, Murayama Y, Arai H, Nishimura F, Takashiba S

Journal of Dental Research 83(7) 546-551 2004 [Refereed]

Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria.

Maeda H, Fujimoto C, Haruki Y, Maeda T, Kokeguchi S, Petelin M, Arai H, Tanimoto I, Nishimura F, Takashiba S

FEMS immunology and medical microbiology 39(1) 81-86 Oct 2003 [Refereed]

Role of helper T cells in the humoral immune responses against 53-kDa outer membrane protein from Porphyromonas gingivalis.

Kato N, Ohyama H, Nishimura F, Matsushita S, Takashiba S, Murayama Y

Oral microbiology and immunology 20 112-117 Apr 2005 [Refereed]

Thiazolidinedione (pioglitazone) blocks P. gingivalis- and F. nucleatum, but not E. coli, lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) production in adipocytes.

Yamaguchi M, Nishimura F, Naruishi H, Soga Y, Kokeguchi S, Takashiba S

Journal of dental research 84 240-244 Mar 2005 [Refereed]

C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect.

Naruishi K, Nishimura F, Yamada-Naruishi H, Omori K, Yamaguchi M, Takashiba S

Transplantation 76(9) 1380-1382 Nov 2003 [Refereed]

Detection of periodontal pathogen Porphyromonas gingivalis by loop-mediated isothermal amplification method.

Maeda H, Kokeguchi S, Fujimoto C, Tanimoto I, Yoshizumi W, Nishimura F, Takashiba S

FEMS immunology and medical microbiology 43 233-239 Feb 2005 [Refereed]

Unique genes induced by mechanical stress in periodontal ligament cells.

Myokai F, Oyama M, Nishimura F, Ohira T, Yamamoto T, Arai H, Takashiba S, Murayama Y

Journal of periodontal research 38(3) 255-261 Jun 2003 [Refereed]

Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese.

Soga Y, Nishimura F, Ohyama H, Maeda H, Takashiba S, Murayama Y

Journal of clinical periodontology 30(6) 524-531 Jun 2003 [Refereed]

Identification of genes differentially regulated in rat alveolar bone wound healing by subtractive hybridization.

Ohira T, Myokai F, Shiomi N, Yamashiro K, Yamamoto T, Murayama Y, Arai H, Nishimura F, Takashiba S

Journal of dental research 83 546-551 Jul 2004 [Refereed]

Ligation of IFN-gamma-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun N-terminal kinase (JNK) pathway.

Meguro M, Nishimura F, Ohyama H, Takashiba S, Murayama Y, Matsushita S

Cytokine 22(5) 107-115 Jun 2003 [Refereed]

High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts.

Omori K, Naruishi K, Nishimura F, Yamada-Naruishi H, Takashiba S

The Journal of biological chemistry 279(8) 6643-6649 Feb 2004 [Refereed]

Antibacterial activity of synthetic human B defensin-2 against periodontal bacteria.

Mineshiba F, Takashiba S, Mineshiba J, Matsuura K, Kokeguchi S, Murayama Y

Journal of the International Academy of Periodontology 5(2) 35-40 Apr 2003 [Refereed]

Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice.

Petelin M, Naruishi K, Shiomi N, Mineshiba J, Arai H, Nishimura F, Takashiba S, Murayama Y

Experimental and molecular pathology 76 76-81 Feb 2004 [Refereed]

CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects.

Soga Y, Nishimura F, Ohtsuka Y, Araki H, Iwamoto Y, Naruishi H, Shiomi N, Kobayashi Y, Takashiba S, Shimizu K, Gomita Y, Oka E

Life sciences 74(7) 827-834 Jan 2004 [Refereed]

Application of denaturing gradient gel electrophoresis (DGGE) to the analysis of microbial communities of subgingival plaque.

Fujimoto C, Maeda H, Kokeguchi S, Takashiba S, Nishimura F, Arai H, Fukui K, Murayama Y

Journal of periodontal research 38 440-445 Aug 2003 [Refereed]

Gene profiling in human periodontal ligament fibroblasts by subtractive hybridization.

Yamamoto T, Myokai F, Nishimura F, Ohira T, Shiomi N, Yamashiro K, Arai H, Murayama Y, Takashiba S

Journal of dental research 82 641-645 Aug 2003 [Refereed]

Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis.

Iwamoto Y, Nishimura F, Soga Y, Takeuchi K, Kurihara M, Takashiba S, Murayama Y

Journal of periodontology 74 1231-1236 Aug 2003 [Refereed]

Perspective of cytokine regulation for periodontal treatment: fibroblast biology.

Takashiba S, Naruishi K, Murayama Y

Journal of periodontology 74 103-110 Jan 2003 [Refereed]

Unique genes induced by mechanical stress in periodontal ligament cells

Myokai F, Oyama M, Nishimura F, Ohira T, Yamamoto T, Arai H, Takashiba S, Murayama Y

Journal of Periodontal Research 38(3) 255-261 2003 [Refereed]

Tumor necrosis factor-alpha gene (TNF-alpha)-1031/-863,-857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese

Soga Y, Nishimura F, Ohyama H, Maeda H, Takashiba S, Murayama Y

Journal of Clinical Periodontology 30(6) 524-531 2003 [Refereed]

Impairment of gingival fibroblast adherence by IL-6/sIL-6R

Naruishi K, Takashiba S, Nishimura F, Chou HH, Arai H, Yamada H, Murayama Y

Journal of Dental Research 80(5) 1421-1424 2001 [Refereed]

Characterization of two genes encoding ferritin-like protein in Actinobacillus actinomycetemcomitans.

Hirosue M, Kokeguchi S, Maeda H, Nishimura F, Takashiba S, Murayama Y

Microbiology and immunology 45(10) 721-727 2001 [Refereed]

Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation.

Ohyama H, Nishimura F, Meguro M, Takashiba S, Murayama Y, Matsushita S

Cytokine 17 175-181 Feb 2002 [Refereed]

T cell responses to major membrane protein II (MMP II) of Mycobacterium leprae are restricted by HLA-DR molecules in patients with leprosy.

Ohyama H, Matsushita S, Nishimura F, Kato N, Hatano K, Takashiba S, Murayama Y

Vaccine 20 475-482 Nov 2001 [Refereed]

Subgingival microflora and antibody responses against periodontal bacteria of young Japanese patients with type 1 diabetes mellitus.

Takahashi K, Nishimura F, Kurihara M, Iwamoto Y, Takashiba S, Miyata T, Murayama Y

Journal of the International Academy of Periodontology 3 104-111 Oct 2001 [Refereed]

Impairment of gingival fibroblast adherence by IL-6/sIL-6R.

Naruishi K, Takashiba S, Nishimura F, Chou HH, Arai H, Yamada H, Murayama Y

Journal of dental research 80 1421-1424 May 2001 [Refereed]

Misc

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Site-level progression of periodontal disease during a follow-up period

Yoshiaki Nomura, Toshiya Morozumi, Taneaki Nakagawa, Tsutomu Sugaya, Masamitsu Kawanami, Fumihiko Suzuki, Keiso Takahashi, Yuzo Abe, Soh Sato, Asako Makino-Oi, Atsushi Saito, Satomi Takano, Masato Minabe, Masato Minabe, Yohei Nakayama, Yorimasa Ogata, Hiroaki Kobayashi, Yuichi Izumi, Naoyuki Sugano, Koichi Ito, Satoshi Sekino, Yukihiro Numabe, Chie Fukaya, Nobuo Yoshinari, Mitsuo Fukuda, Toshihide Noguchi, Tomoo Kono, Makoto Umeda, Osamu Fujise, Fusanori Nishimura, Atsutoshi Yoshimura, Yoshitaka Hara, Toshiaki Nakamura, Kazuyuki Noguchi, Erika Kakuta, Nobuhiro Hanada, Shogo Takashiba, Yasuharu Amitani, Hiromasa Yoshie

PLoS ONE 12(12) e0188670-e0188670 Dec 2017

© 2017 Nomura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...

Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells

Shinsuke Kochi, Keisuke Yamashiro, Shoichi Hongo, Tadashi Yamamoto, Yuki Ugawa, Masayuki Shimoe, Mari Kawamura, Chiaki Hirata-Yoshihara, Hidetaka Ideguchi, Hiroshi Maeda, Shogo Takashiba

Molecular and Cellular Biochemistry 436(1-2) 39-48 Dec 2017

© 2017, Springer Science+Business Media New York. Gingival epithelial cells form a physiological barrier against bacterial invasion. Excessive bacterial invasion destroys the attachment between the tooth surface and the epithelium, resulting in pe...

Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT<inf>2A</inf>and 5-HT<inf>2B</inf>receptors in chondrocytes

Ayaka Hori, Ayaka Hori, Takashi Nishida, Shogo Takashiba, Satoshi Kubota, Satoshi Kubota, Masaharu Takigawa

PLoS ONE 12(11) e0188014-e0188014 Nov 2017

© 2017 Hori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr...

Rho-kinase regulates extracellular matrix-mediated osteogenic differentiation of periodontal ligament cells

Yuki Ugawa, Tadashi Yamamoto, Mari Kawamura, Keisuke Yamashiro, Masayuki Shimoe, Kazuya Tomikawa, Shoichi Hongo, Hiroshi Maeda, Shogo Takashiba

Cell Biology International 41(6) 651-658 Jun 2017

© 2017 International Federation for Cell Biology The periodontal ligament (PDL) cells contain heterogeneous mesenchymal cell populations, which have the ability to differentiate into cells that produce adjacent mineralized tissues and abundant ext...

Assessing the progression of chronic periodontitis using subgingival pathogen levels: A 24-month prospective multicenter cohort study

E. Kakuta, Y. Nomura, T. Morozumi, T. Nakagawa, T. Nakamura, K. Noguchi, A. Yoshimura, Y. Hara, O. Fujise, F. Nishimura, T. Kono, M. Umeda, M. Fukuda, T. Noguchi, N. Yoshinari, C. Fukaya, S. Sekino, Y. Numabe, N. Sugano, K. Ito, H. Kobayashi, Y. Izumi, H. Takai, Y. Ogata, S. Takano, M. Minabe, M. Minabe, A. Makino-Oi, A. Saito, Y. Abe, S. Sato, F. Suzuki, K. Takahashi, T. Sugaya, M. Kawanami, N. Hanada, S. Takashiba, H. Yoshie

BMC Oral Health 16(17) 46 Jan 2017

© 2017 The Author(s). Background: The diagnosis of the progression of periodontitis presently depends on the use of clinical symptoms (such as attachment loss) and radiographic imaging. The aim of the multicenter study described here was to evalua...

Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study

T. Morozumi, T. Nakagawa, Y. Nomura, T. Sugaya, M. Kawanami, F. Suzuki, K. Takahashi, Y. Abe, S. Sato, A. Makino-Oi, A. Saito, S. Takano, M. Minabe, M. Minabe, Y. Nakayama, Y. Ogata, H. Kobayashi, Y. Izumi, N. Sugano, K. Ito, K. Ito, S. Sekino, Y. Numabe, C. Fukaya, N. Yoshinari, M. Fukuda, T. Noguchi, T. Kono, M. Umeda, O. Fujise, F. Nishimura, A. Yoshimura, Y. Hara, T. Nakamura, K. Noguchi, E. Kakuta, E. Kakuta, N. Hanada, S. Takashiba, H. Yoshie

Journal of Periodontal Research 51(6) 768-778 Dec 2016

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background and Objective: A diagnosis of periodontitis progression is presently limited to clinical parameters such as attachment loss and radiographic imaging. The aim of this m...

Smad2 overexpression enhances adhesion of gingival epithelial cells

Shoichi Hongo, Tadashi Yamamoto, Keisuke Yamashiro, Masayuki Shimoe, Kazuya Tomikawa, Yuki Ugawa, Shinsuke Kochi, Hidetaka Ideguchi, Hiroshi Maeda, Hiroshi Maeda, Shogo Takashiba

Archives of Oral Biology 71 46-53 Nov 2016

© 2016 Elsevier Ltd Objective Gingival epithelial cells play an important role in preventing the initiation of periodontitis, by their hemidesmosomal adhesion to the tooth root surface. Adhesion requires integrin-extracellular matrix (ECM) interac...

The potential of positron emission tomography/computerized tomography (PET/CT) scanning as a detector of high-risk patients with oral infection during preoperative staging

Keisuke Yamashiro, Keisuke Yamashiro, Makoto Nakano, Koichi Sawaki, Fumihiko Okazaki, Yasuhisa Hirata, Shogo Takashiba

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 122(2) 242-249 Aug 2016

© 2016 Elsevier Inc. Objective It is sometimes difficult to determine during the preoperative period whether patients have oral infections; these patients need treatment to prevent oral infection–related complications from arising during medical t...

Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: A randomized double-blind clinical trial

K. Takeuchi-Hatanaka, T. Yasuda, K. Naruishi, K. Naruishi, K. Katsuragi-Fuke, K. Katsuragi-Fuke, J. Inubushi, H. Ootsuki, H. Ootsuki, H. Maeda, H. Maeda, S. Takashiba

Journal of Periodontal Research 51(3) 321-331 Jun 2016

© 2016 John Wiley & Sons A/S. Background and Objective: The biochemical effects of an over-the-counter (OTC) medication were studied, which consists of a single-tuft brush containing cetylpyridinium chloride as a bactericidal agent, dipotassium ...

Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects

Masahiro Kitamura, Motoki Akamatsu, Masamitsu Kawanami, Yasushi Furuichi, Takeo Fujii, Mari Mori, Kazushi Kunimatsu, Hidetoshi Shimauchi, Yorimasa Ogata, Matsuo Yamamoto, Taneaki Nakagawa, Shuichi Sato, Koichi Ito, Takefumi Ogasawara, Yuichi Izumi, Kazuhiro Gomi, Kazuhisa Yamazaki, Hiromasa Yoshie, Mitsuo Fukuda, Toshihide Noguchi, Shogo Takashiba, Hidemi Kurihara, Toshihiko Nagata, Takafumi Hamachi, Katsumasa Maeda, Makoto Yokota, Ryuji Sakagami, Yoshitaka Hara, Kazuyuki Noguchi, Toshi Furuuchi, Takashi Sasano, Enyu Imai, Masatoshi Ohmae, Hayuru Koizumi, Mitsuru Watanuki, Shinya Murakami

Journal of Bone and Mineral Research 31(4) 806-814 Apr 2016

© 2016 American Society for Bone and Mineral Research. We investigated the efficacy, safety, and clinical significance of trafermin, a recombinant human fibroblast growth factor (rhFGF)-2, for periodontal regeneration in intrabony defects in Phase...

Synthetic terrein inhibits progression of head and neck cancer by suppressing angiogenin production

Akane Shibata, Soichiro Ibaragi, Hiroki Mandai, Toki Tsumura, Koji Kishimoto, Tatsuo Okui, Nur Mohammad Monsur Hassan, Tsuyoshi Shimo, Kazuhiro Omori, Guo Fu Hu, Shogo Takashiba, Seiji Suga, Akira Sasaki

Anticancer Research 36(5) 2161-2168 Jan 2016

Background/Aim: Head and neck cancers are the fifth most common cancer type worldwide, affecting more than half a million patients annually. Development of effective therapeutic drugs is, therefore, required for this type of disease. This study as...

Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study

Chieko Kudo, Wee Soo Shin, Masato Minabe, Masato Minabe, Kazuo Harai, Kazuo Harai, Kai Kato, Hiroaki Seino, Eiji Goke, Nobuhiro Sasaki, Takemasa Fujino, Nobuichi Kuribayashi, Youko Onuki Pearce, Masato Taira, Hiroshi Maeda, Shogo Takashiba

Odontology 103(3) 314-321 Sep 2015

© 2014, The Society of The Nippon Dental University. It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of “chronic inflammation”. Several reports have indicated that periodontal infection is related to a...

Cut-off values of Functional Independence Measure scores for discharge destination

Koji Naruishi, Koji Naruishi, Koji Naruishi, Akiko Kunita, Toshihiko Nagata, Shogo Takashiba, Shogo Takashiba, Seiji Adachi

Geriatrics and Gerontology International 15(5) 670-671 May 2015

Group A. Consensus paper. Plaque control--home remedies practiced in developing countries

Sebastian Ciancio, Dagmar E.lse Slot, Thomas Van Dyke, Foud Al Bayaty, Nawarat W.ara Aswapati, Vinayak Joshi, Kaye Kendall, Keung Leung, Nisha Patel, Shaili Pradhan, Cyanthi Senevirante, Shogo Takashiba, Priya Vidhale

Journal of the International Academy of Periodontology 17(1) 17-20 Jan 2015

Identification of transactivation-responsive DNA-binding protein 43 (TARDBP43; TDP-43) as a novel factor for TNF-α expression upon lipopolysaccharide stimulation in human monocytes

H. Murata, T. Hattori, H. Maeda, S. Takashiba, M. Takigawa, J. Kido, T. Nagata

Journal of Periodontal Research 50(4) 452-460 Jan 2015

© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Background and Objective: Tumor necrosis factor alpha (TNF-α) is a major cytokine implicated in various inflammatory diseases. The nature of the nuclear factors associated with ...

Interdisciplinary orthodontic treatment for a patient with generalized aggressive periodontitis: Assessment of IgG antibodies to identify type of periodontitis and correct timing of treatment

Yoshihito Ishihara, Kazuya Tomikawa, Toru Deguchi, Tadashi Honjo, Koji Suzuki, Takayuki Kono, Takuo Kuboki, Hiroshi Kamioka, Shogo Takashiba, Takashi Yamashiro

American Journal of Orthodontics and Dentofacial Orthopedics 147(6) 766-780 Jan 2015

© 2015 American Association of Orthodontists. Aggressive periodontitis is a great challenge to clinicians when providing orthodontic treatment because of the potential for progression of periodontal disease. In this article, we report the successf...

Predictors of improved functional outcome in elderly inpatients after rehabilitation: A retrospective study

Koji Naruishi, Koji Naruishi, Akiko Kunita, Katsuyuki Kubo, Katsuyuki Kubo, Toshihiko Nagata, Shogo Takashiba, Shogo Takashiba, Seiji Adachi

Clinical Interventions in Aging 9 2133-2141 Dec 2014

© 2014 Naruishi et al. Purpose: The number of elderly inpatients has been steadily increasing worldwide. However, the ability to predict the degree of improvement of functional capacity after comprehensive examination of elderly inpatients is stil...

Osteogenic differentiation regulated by Rho-kinase in periodontal ligament cells

Tadashi Yamamoto, Yuki Ugawa, Keisuke Yamashiro, Masayuki Shimoe, Kazuya Tomikawa, Kazuya Tomikawa, Shoichi Hongo, Shinsuke Kochi, Hidetaka Ideguchi, Hiroshi Maeda, Shogo Takashiba

Differentiation 88(2-3) 33-41 Sep 2014

© 2014 International Society of Differentiation. The periodontal ligament is a multifunctional soft connective tissue, which functions not only as a cushion supporting the teeth against occlusal force, but is also a source of osteogenic cells that...

Overexpression of Smad2 inhibits proliferation of gingival epithelial cells

M. Shimoe, T. Yamamoto, N. Shiomi, K. Tomikawa, K. Tomikawa, S. Hongo, K. Yamashiro, T. Yamaguchi, H. Maeda, S. Takashiba

Journal of Periodontal Research 49 290-298 Jan 2014

Background and Objective: Spatiotemporal inhibition of apical migration and proliferation of gingival epithelium are significant factors involved in periodontal regeneration. Transforming growth factor β (TGF-β) is important in multiple aspects of...

Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report

Chieko Kudo, Hiroshi Wakabayashi, Masayuki Shimoe, Hiroya Kobayashi, Hiroya Kobayashi, Takashi Ito, Toshinori Ohkawa, Toshinori Ohkawa, Arisa Isoshima-Nakamura, Junji Mineshiba, Junji Mineshiba, Norie Yoshioka, Kumiko Nawachi, Hiroshi Maeda, Toshihiko Matsuo, Hirofumi Makino, Shogo Takashiba

Clinical Case Reports 2(6) 274-289 Jan 2014

© 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. We report a case of Behçet's disease which was aggravated by psychological stress and oral infection. The control of oral infection under medical and dental collaborat...

Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report

Kazuhiro Omori, Yoshihisa Hanayama, Koji Naruishi, Koji Naruishi, Kentaro Akiyama, Hiroshi Maeda, Fumio Otsuka, Shogo Takashiba

Clinical Case Reports 2(6) 286-295 Jan 2014

© 2014 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. It has been suggested that vitamin C deficiency/scurvy is associated with gingival inflammatory changes; however, the disorder is very infrequently encountered in the ...

Medical microbiological approach to Archaea in oral infectious diseases

Hiroshi Maeda, Kimito Hirai, Junji Mineshiba, Tadashi Yamamoto, Susumu Kokeguchi, Shogo Takashiba

Japanese Dental Science Review 49(2) 72-78 May 2013

Recent advances in molecular biological techniques have yielded large amounts of information regarding the oral microflora. The microbiological communities were shown to be more diverse than previously thought and to include a number of previously...

Anti-bacterial Measures Targeted at Exposed Tooth Root and Denture Surface : Development of Drug-Delivery System of Anti-microbes and Materials Preventive for Biofilm

TAKASHIBA Shogo, TERASHITA Masamichi, MATSUO Takashi, TERANAKA Toshio, TANAKA Takahiro, HATANAKA Kazu, NAMBA Naoko

日本歯科医学会誌 = Journal of the Japanese Association for Dental Science : JJDS (32) 54-58 Mar 2013

Basic Research to Clinical Dentistry : Potentiality of plasma IgG antibody titer test against to periodontal pathogens

OMORI Kazuhiro, KUDO Chieko, NARUISHI Koji, MAEDA Hiroshi, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 55(1) 9-14 Mar 2013

15-year Clinical Course of a Patient with Generalized Aggressive Periodontitis Followed with Regular examination of the serum titers of IgG antibodies against periodontal bacteria

TOMIKAWA Kazuya, IWAMOTO Yoshihiro, OHE Hyogo, ARAI Hideo, YAMAMOTO Tadashi, MAEDA Hiroshi, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 54(2) 193-202 Jun 2012

For the treatment of patients with aggressive periodontitis, a thorough control of the infection is required to reduce the disease activity. Detection of periodontal pathogens by a polymerase chain reaction-based method or measurement of the serum...

A Foreword

TAKASHIBA Syogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 54(1) 3-4 Mar 2012

Long-term Benefits of Regenerative Therapy Using FGF-2

KITAMURA Masahiro, FURUICHI Yasushi, FUJII Takeo, KAWANAMI Masamitsu, KUNIMATSU Kazushi, SHIMAUCHI Hidetoshi, YAMADA Satoru, OGATA Yorimasa, IZUMI Yuichi, ITO Koichi, NAKAGAWA Taneaki, ARAI Takashi, YAMAZAKI Kazuhisa, YOSHIE Hiromasa, NOGUCHI Toshihide, SIBUTANI Toshiaki, TAKASHIBA Syogo, KURIHARA Hidemi, NAGATA Toshihiko, YOKOTA Makoto, MAEDA Katsumasa, HIROFUJI Takao, SAKAGAMI Ryuji, HARA Yoshitaka, NOGUCHI Kazuyuki, OGASAWARA Takefumi, MURAKAMI Shinya

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 54(1) 38-45 Mar 2012

Basic fibroblast growth factor (FGF-2) is one of the major candidates as a periodontal tissue regenerating agent. A series of animal studies and clinical trials have demonstrated its efficacy and safety. In the present study, we surveyed the eight...

Establishment of Examination for Judgment of Effects of Prevention and Treatment for Periodontal Treatment According to Clinical Database

TAKASHIBA Shogo, YAMADA Satoru, ITO Koichi, TAKATA Takashi, SHIMAUCHI Hidetoshi, NAGATA Yoshihiko, YOSHIE Hiromasa, KURIHARA Hidemi

日本歯科医学会誌 = Journal of the Japanese Association for Dental Science : JJDS 30(30) 70-74 Mar 2011

Drug delivery by sensing its concentration

YOSHIDA Y, NAMBA N, NAGAOKA N, NAKAMURA M, TAKASHIBA S, SUZUKI K

The journal of the Japanese Society for Dental Materials and Devices 29(5) Sep 2010

Carrier materials with sensor for drug concentration hold great promise as smart delivery systems for drugs which have strong side effects, such as anticancer agents and bactericides. However, any carriers sensing drug concentration have not been ...

Clinical and microbiological effect of newly developed OTC periodontal ointment-containing applicator with brush on the SPT phase

INUBUSHI Junya, HATANAKA Kazu, YASUDA Takako, NARUISHI Koji, OOTSUKI Hidehiko, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 52(3) 225-238 Sep 2010

It is important for maintaining improved periodontal tissue health during supportive periodontal therapy (SPT) to restrain infection caused by periodontopathic bacteria by the patients' own self control in addition to periodic professional interve...

A Novel Real-Time DNA Detection System for Loop-Mediated Isothermal Amplification Method

KAKUGAWA Koji, YAMADA Kenji, MAEDA Hiroshi, TAKASHIBA Shougo

IEEJ Transactions on Electronics, Information and Systems 130(5) 807-812 May 2010

We developed a novel real-time DNA detection system for loop-mediated isothermal amplification (LAMP) method. Our prototype was composed of a thermostatic chamber, a hole slide glass, LED and a web camera. The reaction mixture was injected into th...

A novel real-time DNA detection system for loop-mediated isothermal amplification method

Koji Kakugawa, Kenji Yamada, Hiroshi Maeda, Shougo Takashiba

IEEJ Transactions on Electronics, Information and Systems 130 Jan 2010

Bactericide delivery system containing the phosphorylated polysaccharide as carrier material

YOSHIDA Y, NAMBA N, NAGAOKA N, NAKAMURA M, TAKASHIBA S, SUZUKI K

Journal of the Japanese Society for Dental Materials and Devices 28(5) Sep 2009

To effectively exploit the properties of antibacterial agents, we synthesized phosphorylated polysaccharides as the carrier for bactericide delivery to surface of apatitic substrates. It was indicated that 0.01% phosphorylated pullulan and 0.01% c...

Proposal of Prosthetic Treatment for Patients with Periodontal Disease

ISHIBASHI Kanji, YOSHIE Hiromasa, KAWANAMI Masamitsu, IKEDA Masahiko, YAMAMORI Tetsuo, SAKAGAMI Ryuji, IKEDA Yasuhiro, TSUNODA Masatake, YASUDA Noboru, TAKASHIBA Shogo, WATANABE Fumihiko, MINABE Masato, ITOH Sozo, WATANABE Hisashi, YAMADA Satoru, HIRAI Toshihiro

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 51(2) 191-212 Jun 2009

歯周病は中年期以降の日本人の約8割が罹患する炎症性疾患であり，口腔内の健康のみにとどまらず，全身の健康状態にもさまざまな影響を及ぼすことが知られている。歯周治療の基本は炎症のコントロールであり，この目的で，歯と歯周組織に付着した細菌性プラークと細菌由来物質を徹底して機械的に除去することが必要である。歯科医師・歯科衛生士が行うスケーリング・ルートプレーニングと，患者自らが行うブラッシングなどの日々の口腔ケアがこれに相当する。<BR>　中等度以上に進行した歯周病患者の治療においては，炎症のコン...

Effect of Polygonum tinctoriumextract against gingival inflammation

HATANAKA Kazu, FUKE Kyoko, SENO Kyoko, TOMIYAMA Takashi, IWAKI Kanso, KUNIKATA Toshio, MASAKI Naoya, FUKUDA Shigeharu, MAEDA Hiroshi, ARAI Hideo, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 50(3) 167-175 Sep 2008

An indigo dye plant, Polygonum tinctorium has been shown to have anti-inflammatory and antibacterial effects against pathogens causing periodontitis. In this study, the effect of Polygonum tinctorium extract on gingival inflammation ...

A role of the nrdD-like gene related to abscess-forming ability of Porphyromonas gingivalis

SONOI Norihiro, MAEDA Hiroshi, NARUISHI Koji, KOKEGUCHI Susumu, HASSAN Wael Amgad, SAWADA Koichi, KOIDE Yasushi, YAMABE Kokoro, TANIMOTO Ichiro, ARAI Hideo, TAKASHIBA Shogo

日本歯科保存学雑誌 51 May 2008

Bactericide delivery system for preventing dental caries and periodontal disease

NAMBA Naoko, YOSHIDA Yasuhiro, MATSUURA Kaori, ITO Takashi, MAEDA Hiroshi, ARAI Hideo, SUZUKI Kazuomi, TAKASHIBA Shogo

日本歯科保存学雑誌 51 May 2008

Pathophysiology of Periapical Lesions during Root Canal Treatment based on Microarray Analysis in Experimental Rat Periapical Lesions

TOMIYAMA Takashi, NARUISHI Koji, ARIAS MARTINEZ Zulema Rosalia, YAMASHIRO Keisuke, MAEDA Hiroshi, ARAI Hideo, TAKASHIBA Shogo

日本歯科保存学雑誌 51 May 2008

P-6 Antibacterial effect of CPC immobilized in the resin matrix

NAMBA N., YOSHIDA Y., NAGAOKA N., SUZUKI K., TAKASHIBA S.

Journal of the Japanese Society for Dental Materials and Devices 27(2) Mar 2008

Examination of α2 Integrin Polymorphism in Drug-induced Gingival Overgrowth : α2 Integrin+1648 G/A Polymorphism

MIHARA-WADA Chie, SOGA Yoshihiko, TAKASHIBA Shogo, NAGATA Toshihiko, KIDO Jun-ichi, BANDO Mika, KATAOKA Masatoshi, KUBOTA Takehiko, ITAGAKI Manami, SHIMADA Yasuko, TAI Hideaki, YOSHIE Hiromasa, NISHIMURA Fusanori

The Japanese Journal of Conservative Dentistry 51(4) 464-471 2008

Drug-induced gingival overgrowth is a side effect observed in patients taking calcium channel blockers, anti-epileptic drugs or immunosuppressant drugs. Some reports had showed different mechanisms for the incidence of gingival overgrowth, and we ...

Changes in the Oral Bacterial Microflora of Patients Receiving Bone Marrow Transplantation

HASSAN Wael, TANIMOTO Ichiro, MAEDA Hiroshi, SUGIURA Yuko, SOGA Yoshihiko, KOKEGUCHI Susumu, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 Oct 2007

A Case of Acute Periapical Periodontitis Which is Difficult to Find Infection Route

IWAMOTO Yoshihiro, ARAI Hideo, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 Oct 2007

Practice Training of Conservative Dentistry on Postgraduate Clinical Training Course at Okayama University Hospital

KONO Takayuki, YAMAJI Kozo, YOSHIYAMA Masahiro, ARAI Hideo, TAKASHIBA Shogo, TORII Yasuhiro

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 Oct 2007

Effect of Polygonum tinctorium extract against gingival inflammation

HATANAKA Kazu, FUKE Kyoko, MATSUURA Kaori, SENOO Kyoko, TOMIYAMA Takashi, KANDA Noriko, UENISHI Yumi, IWAKI Kanso, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 Oct 2007

A survey of periodontal basic training for dental students

SUZUKI Joichiro, NAKASHIMA Keisuke, KUNIMATSU Kazushi, TAKASHIBA Shogo, HARA Yoshitaka, IZUMI Yuichi, YOKOTA Makoto, KAMOI Kyuichi, ODA Shigeru, FUKUDA Mitsuo, KAWANAMI Masamitsu, NOGUCHI Toshihide

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 49(2) 162-174 Jun 2007

In clinical dentistry, dental students have to master not only their knowledge of dentistry, but also their dental skills and communication skills with patients. The purpose of this study was to collect basic data on periodontal basic training at ...

Effects of HLA-II-induced CXC chemokines in human gingival fibroblasts on the proliferation of HUVEC cells

OKADA Yuka, NISHIMURA Fusanori, MEGURO Michio, YOSHIZAWA Sayuri, HATANAKA TAKEUCHI Kazu, ARAI Hideo, OHYAMA Hideki, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 May 2007

Effects of FIP-2 Isolated from Rat Wounded Pulp on Inflammatory Regulators and Cell Death

SENOO Kyoko, YAMAMOTO Tadashi, MYOKAI Fumio, YAMASHIRO Keisuke, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 May 2007

Utility of various gargle watched from a sterilization effect for oral bacteria

MATSUURA Kaori, MAEDA Hiroshi, KAIGAI Atsuko, SONOI Norihiro, NAMBA Naoko, TANIMOTO Ichiro, ARAI Hideo, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 May 2007

Gene Profiles during Root Canal Treatment in Experimental Periapical Lesions

MARTINEZ Zulema Rosalia Arias, NARUISHI Koji, YAMASHIRO Keisuke, MATSUURA Kaori, NAMBA Naoko, MAEDA Hiroshi, ARAI Hideo, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 50 May 2007

Classification System for Periodontal Diseases by The Japanese Society of Periodontology (2006)

SHIMAUCHI Hidetoshi, TAKASHIBA Shogo, NISHIHARA Tatsuji, KAWASE Toshio, TAKATA Takashi, HARA Yoshitaka, YAMAZAKI Kazuhisa, YAMAMOTO Matsuo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 49(1) 3-12 Mar 2007

A Clinical Case of Chronic Periodontitis with the Multiple Risk Factor Syndrome

SHIMOE Masayuki, IWAMOTO Yoshihiro, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 49(1) 61-70 Mar 2007

Multiple risk factor clustering syndrome (diabetes, dyslipidemia, hypertension, and obesity) is characterized by an increased risk of ischemic heart events, such as myocardial infarction. In this case report, we describe the clinical course of a p...

Evaluation of Platelet-Rich Plasma (PRP) Combined with Autogenous Bone Graft for Periodontal Regeneration Therapy of Periodontal Intrabony Defects in Humans

TOMIYAMA Takashi, IWAMOTO Yoshihiro, YOSHIZUMI Wakako, SHIMIZU Akemi, KONO Takayuki, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 49(1) 71-72 Mar 2007

Recent studies have suggested that the use of platelet-rich plasma (PRP) combined with bone graft materials may be effective in the treatment of periodontal intrabony defects in humans. However, no clinical studies of periodontal regeneration ther...

Practice Training of Conservative Dentistry on Postgraduate Clinical Training Course at Okayama University Hospital of Medicine and Dentistry

KONO Takayuki, YAMAJI Kozo, YOSHIYAMA Masahiro, ARAI Hideo, TAKASHIBA Shogo, TORII Yasuhiro

The Japanese Journal of Conservative Dentistry 50(6) 731-739 2007

We have developed and applied a new electronic portfolio system to educate 65 dental residents for postgraduate clinical training in Okayama University Hospital of Medicine and Dentistry since the 2006 academic year. The purpose of this study was ...

Detection of mecA and spa Genes by Loop-mediated Isothermal Amplification Method

KOIDE Yasushi, MAEDA Hiroshi, MURAUCHI Toshimitsu, TANIMOTO Ichiro, KOKEGUCHI Susumu, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 Oct 2006

Involvement of FAK in HLA-II-induced signaling associated with cytokine production in gingival fibroblasts

YOSHIZAWA Sayuri, NISHIMURA Fusanori, MEGURO Michio, TAKEUCHI HATANAKA Kazu, OHYAMA Hideki, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 Oct 2006

Evaluation of E-learning System for Clinical Education of Periodontology & Endodontology

ARAI Hideo, TANIMOTO Ichiro, IWAMOTO Yoshihiro, KOIDE Yasushi, TOMIKAWA Kazuya, TOMIYAMA Takashi, SHIMOE Masayuki, SONOI Norihiro, NARUISHI Koji, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 Oct 2006

A study on the signal transduction molecules activated in LPS-stimulated monocyte under hyperglycemia

IWATA Hirotaka, NISHIMURA Fusanori, SOGA Yoshihiko, MEGURO Michio, YOSHIZAWA Sayuri, OKADA Yuka, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 Apr 2006

A study for possible markers linking between atherosclerosis and periodontitis in coronary atherosclerotic patients (II)

HONDA Tomoyuki, DOMON Hisanori, AMANUMA Ryoko, OKUI Takafumi, KAJITA Keiko, NAKAJIMA Takako, KUDO Chieko, NISHIMURA Fusanori, TAKASHIBA Shogo, YAMAZAKI Kazuhisa

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 Apr 2006

Human Gingival Fibroblasts Produce GRO (growth-related oncogene) by Stimulation via HLA-DR Molecules

MEGURO Michio, NISHIMURA Fusanori, OHYAMA Hideki, YOSHIZAWA Sayuri, HATANAKA TAKEUCHI Kazu, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 Apr 2006

Clinical Usefulness of Fingertip-Plasma IgG Titer Examination as Laboratory Test on Periodontal Bacteria

KUDO Chieko, HISAEDA Aya, SUGIYAMA Yasuhei, TOYAMA Hiroshi, WATANABE Hiromi, MAEHATA Eisuke, TAKEDA Kenji, EGUCHI Toru, AOI Rie, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯周病学会会誌 48 Mar 2006

Gingival Overgrowth-inducing Drugs Supress DAPK(death-associated protein kinase)Activity

OKADA Yuka, NISHIMURA Fusanori, MEGURO Michio, YOSHIZAWA Sayuri, IWATA Hirotaka, TAKASHIBA Shogo

日本歯周病学会会誌 48 Mar 2006

Caveolin-1 Mediates IL-6/sIL-6R-induced Cathepsin-B, -L Activation in Human Gingival Fibroblasts

YAMAGUCHI Tomoko, NARUISHI Koji, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯周病学会会誌 48 Mar 2006

Microarray Analysis of Gene Expression Profiles Induced by High Glucose in Human Gingival Fibroblasts

YAMASHIRO Keisuke, NARUISHI Koji, YAMASHITA Akiko, SENOO Kyoko, YAMAGUCHI Tomoko, MYOKAI Fumio, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯周病学会会誌 48 Mar 2006

A Study on the Relationships between the Severity of Periodontitis and Serum IgG Antibody Titer against Porphyromonas gingivalis among Patients with Hematologic Malignancies

SOGA Yoshihiko, TOYAMA Yuu, SONOI Norihiro, IWATA Hirotaka, OKADA Yuka, TOMIYAMA Takashi, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo, IWAMOTO Yoshihiro, TANIMOTO Ichiro, ASADA Kaoru, YOKOI Aya, MEGURO Michio, KUDO Chieko, YOSHIZAWA Sayuri, YAMABE Kokoro

The Japanese Journal of Conservative Dentistry 49(6) 731-738 2006

Infection is a critical issue in immuno-compromised patients such as with hematologic malignancies. Oral infection is no exception. Among various oral infectious diseases, periodontitis is one of the most common diseases. However, currently, very ...

The Effect of Vitamins C and E Supplementation in Non-smokers in Periodontal Maintenance

NAGATA Hideki, SHIZUKUISHI Satoshi, SAHO Teruyuki, NOZAKI Takenori, MURAKAMI Shinya, TAKEUCHI-HATANAKA Kazu, KATSURAGI-FUKE Kyoko, TAKASHIBA Shogo, TAKEMURA Akane

The Japanese Journal of Conservative Dentistry 49(5) 683-692 2006

The purpose of this randomized controlled trial was to investigate the efficacy of dietary supplementation with anotioxidative vitamins, vitamin (C(VC) and E(VE), for preventing progression of periodontal disease in nonsmokers. A total of 42 patie...

Subgingival microflora and antibody responses against periodontal bacteria of young Japanese patients with type 1 diabetes mellitus.

K. Takahashi, F. Nishimura, M. Kurihara, Y. Iwamoto, S. Takashiba, T. Miyata, Y. Murayama

Journal of the International Academy of Periodontology 3(4) 104-111 Jan 2001

Periodontal disease is a complication of patients with type 1 diabetes mellitus (T1DM), although the mechanisms responsible for this relationship remain unclear. The aim of this study was to examine oral manifestations and the prevalence of period...

Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth.

H. Yamada, F. Nishimura, K. Furuno, K. Naruishi, Y. Kobayashi, S. Takashiba, Y. Murayama

Journal of the International Academy of Periodontology 3 42-47 Jan 2001

Epileptic patients taking phenytoin with gingival-overgrowth and those without gingival-overgrowth were compared for daily drug dose, plasma total phenytoin concentration, plasma free-phenytoin concentration and serum IgG antibody titre against 13...

Erratum: Identification by subtractive hybridization of a novel insertion sequence specific for virulent strains of Porphyromonas gingivalis (Infection and Immunity (1999) 67:11 (5621-5625))

K. Sawada, S. Kokeguchi, H. Hongyo, S. Sawada, M. Miyamoto, H. Maeda, F. Nishimura, S. Takashiba, Y. Murayama

Infection and Immunity 68 5470 Jan 2000

Development of 16S rDNA-based PCR assay for detecting Centipeda periodontii and Selenomonas sputigena

S. Sawada, S. Kokeguchi, S. Takashiba, Y. Murayama, Y. Murayama

Letters in Applied Microbiology 30 423-426 Jan 2000

S. SAWADA, S. KOKEGUCHI, S. TAKASHIBA AND Y. MURAYAMA. 2000. To detect oral motile bacteria directly from dental plaque, specific PCR primers for Centipeda periodontii and Selenomonas sputigena were designed based on the sequence analysis of their...

IL-12 production from monocytes induced by stimulus via HLA Class II molecules in humans with leprosy

H. Ohyama, S. Matsushita, K. Hatano, N. Kato, F. Nishimura, S. Takashiba, Y. Murayama

International Journal of Leprosy and Other Mycobacterial Diseases 67 493 Dec 1999

The objective of this study was to assess whether the difference in cellular immune responses against Mycobacterium leprae among clinical forms would be controlled by the balance between IL-12 from monocytes produced by stimulus via HLA class II m...

Identification of periodontal bacteria using DNA probes based on bacterial 16S ribosomal RNA gene-colony hybridization method-

Satoko Sawada, Susumu Kokeguchi, Manabu Miyamoto, Koichi Sawada, Chiyo Fujimoto, Tetsuji Wataki, Masaru Hirosue, Akemi Shimizu, Hsin-Hua Chou, Hidemi Kurihara, Hideo Arai, Shogo Takashiba, Yoji Murayama

Journal of the Japanese Society of Periodontology 40(4) 475-485 Dec 1998

A new method to detect periodontal bacteria was developed by adapting colony hybridization using DNA probes. The synthetic oligonucleotides complementary to species-specific sequence in the 16S ribosomal RNA (rRNA) gene were designed for the detec...

Study on sgk Expression in Cultured Human Periodontal Ligament Fibroblasts Stimulated with Hyper Osmotic Stress

MYOKAI Fumio, SENOO Kyoko, YAMASHIRO Keisuke, YAMAMOTO Tadashi, OYAIZU Kosuke, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 48(6) 939-945 Dec 2005

Serum IgG Titer against Periodontal Bacteria as a Diagnostic Marker of Periodontitis Recurrence

SUGI N., KATSURAGI K., OKADA Y., MURATA H., SONOI N., YAMASHITA A., KUDO C., HISAEDA A., SUGIYAMA Y., TOYAMA Y., KONO T., ARAI H., NISHIMURA F., TAKASHIBA S.

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 48 Oct 2005

Identification of periodontitis candidate genes by association study using microsatellite polymorphisms : full length analysis of chromosome 19

TAI Hideaki, SHIMADA Yasuko, KOBAYASHI Tetsuo, TABETA Koichi, YAMAZAKI Kazunisa, ISHIHARA Yuichi, NOGUCHI Toshihide, SOGA Yoshihiko, TAKASHIBA Shogo, KOBAYASHI Terukazu, OKA Akira, INOKO Hidetoshi, YOSHIE Hiromasa

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 48 Oct 2005

Clinical evaluation of a calcium phosphate cement implanted in human alveolar bone defects

SHINOHARA Hiroyuki, KIDO Jun-ichi, NISHIKAWA Seiji, NISHIMURA Yasuyoshi, ISHIDA Hiroshi, WAKANO Yoichi, NAGATA Toshihiko, NAKAGAWA Masatsugu, KONO Takayuki, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo, KURIHARA Hidemi, MURAYAMA Yoji

The Japanese Journal of Conservative Dentistry 40(4) 975-984 Aug 1997

Factors Affecting Prognosis of Teeth Treated by Root Separation and Resection for Furcation Involvement

TOYAMA Yu, IWAMOTO Yoshihiro, SHIMOE Masayuki, TOMIYAMA Takashi, NANBA Naoko, YAMAGUCHI Tomoko, YAMASHITA Akiko, KANDA Noriko, TOMIKAWA Kazuya, NAITO Hitomi, KONO Takayuki, NAKAGAWA Masatsugu, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 48 Oct 2005

Periodontal therapy by local delivery of minocycline Clinical Study of periodontal therapy by LS-007

Keiji KURIMOTO, Osamu ISOSHIMA, Yuka NAORA, Takashi ANADA, Yoshitomo KOBAYASHI, Mitsuharu KOBAYASHI, Hideo ARAI, Shogo TAKASHIBA, Hideki NANBA, Masayuki YOKOYAMA, Yuka MITSUDA, Yumi MIZUSHIMA, Yoshio NOMURA, Yoji MURAYAMA, Masatoshi UEDA, Yoshihiro TERANISHI, Kazuyuki FUJIWARA, Akiko HASHIZUME, Shinpei KAMAYA, Yoko HOSOYAMA, Kenji UEBA, Kazuyuki ONISHI, Takeo SHIRAI, Satoshi OHASHI, Hirosuke HIGASHI, Yoshifumi KIOKA, Shigeyoshi MINAMIBAYASHI, Mayumi TANAKA, Takuya KITAMURA, Kazuto MAKIGUSA, Akira YAMAOKA, Ryoji URAGUCHI, Satsuki HAGIWARA, Mitsuo FUKUDA, Sigeru ODA, Cherng-Jong LIN, Wataru TAKEFUTA, Toyotsune MERA, Daizou MINEGISHI, Makoto UMEDA, Hiroshi NAKAMOTO, Hirofumi INATOMI, Narongsak Laosrisin, Toshihide NOGUCHI, Isao ISHIKAWA

Journal of the Japanese Society of Periodontology 30(1) 191-205 Mar 1988

Our previous studies have been performed to establish methods for local delivery of Minocycline hydrochloride (MINO: Lederle Japan, LTD, Tokyo) in a therapy for periodontal disease. This study was done clinically to evaluate the effectiveness, saf...

Expression of two FIP-2 mRNA forms in rat dental pulp and its regulation by alternative use of promoters

MYOKAI Fumio, OYAMA Masataka, YAMASHIRO Keisuke, SENOO Kyoko, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 47 Oct 2004

Exhaustive Gene Expression Analysis in Cultured Human Periodontal Ligament Fibroblasts by Mechanical Stress

YAMASHIRO Keisuke, MYOKAI Fumio, SENOO Kyoko, YAMAMOTO Tadashi, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 47 Oct 2004

Detection of periodontal pathogens by loop-mediated isothermal amplification method

MIYAGAWA Junko, MAEDA Hiroshi, MURAUCHI Toshimitsui, FUJIMOTO Chiyo, KOKEGUCHI Susumu, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 47 Oct 2004

A study on relief of oral mucositis during the hematopoietic cell transplantation : Influences of the mouth moisturizing on the mucosal pain and infection

SUGIURA Yuko, SOGA Yoshihiko, MEGURO Michio, KUDO Chieko, YAMABE Kokoro, TSUTANI Soichiro, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯周病学会会誌 46 Sep 2004

The Clinical Trials for Periodontal Regeneration by KCB-1D (FGF-2) in the 2 or 3-wall intrabony defects (Part 1) : Evaluation of Efficacy

MURAKAMI Shinya, NAKAJIMA Keisuke, KOWASHI Yusuke, FUJII Takeo, SHIMAUCHI Hidetoshi, SASANO Takashi, FUKUDA Mitsuo, NOGUCHI Toshihide, SHIBUTANI Toshiaki, IWAYAMA Yukio, TAKASHIBA Shogo, KURIHARA Hidemi, KIDO Jun-ichi, NAGATA Toshihiko, HAMACHI Takafumi, MAEDA Katsumasa, HARA Yoshitaka, IZUMI Yuichi, HIROFUJI Takao, KITAMURA Masahiro

日本歯周病学会会誌 46 Sep 2004

Study on Expression of the Gene Isolated form Cultured Human Periodontal Ligament Fibroblasts Stimulated with Mechanical Stress

SENOO Kyoko, MYOKAI Fumio, YAMASHIRO Keisuke, ARAI Hideo, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯周病学会会誌 46 Sep 2004

The effect of periodontal treatment on the clinical course of pustulosis palmaris et plantarisin patient with severe periodontitis-a case report

AKAZAWA Hiroshi, NISHIMURA Fusanori, MAEDA Hiroshi, FUJIMOTO Chiyo, MURAUCHI Toshimitsu, KUDO Chieko, ARAI Hideo, KOKEGUCHI Susumu, TAKASHIBA Shogo

日本歯周病学会会誌 46 Sep 2004

Thiazolidinediones reduces adipocyte mass and markedly suppresses LPS-induced IL-6 production

YAMAGUCHI Mayumi, NISHIMURA Fusanori, NARUISHI Hisa, SOGA Yoshihiko, KOKEGUCHI Susumu, TAKASHIBA Shogo

日本歯周病学会会誌 46 Sep 2004

The Clinical Trials for Periodontal Regeneration by KCB-1D (FGF-2) in the 2 or 3-wall intrabony defects (Part 2) : Evaluation of Safety

KITAMURA Masahiro, NAKAJIMA Keisuke, KOWASHI Yusuke, FUJII Takeo, SHIMAUCHI Hidetoshi, FUKUDA Mitsuo, NOGUCHI Toshihide, SHIBUTANI Toshiaki, IWAYAMA Yukio, TAKASHIBA Shogo, KURIHARA Hidemi, KIDO Jun-ichi, NAGATA Toshihiko, HAMACHI Takafumi, MAEDA Katsumasa, HARA Yoshitaka, IZUMI Yuichi, HIROFUJI Takao, MURAKAMI Shinya

日本歯周病学会会誌 46 Sep 2004

The 18-year Course in the Treatment for a Aggressive Periodontitis Patient : Consideration from Serum Antibody against Periodontopathic Bacteria

ARAI Hideo, SUGI Noriko, KONO Takayuki, GOTO Hiroyuki, HONGYO Hiroshi, SAWADA Koichi, MYOKAI Fumio, TAKASHIBA Shogo

日本歯周病学会会誌 46 Sep 2004

Clinical, microbiological and immunological studies on a patient with rapidly progressive periodontitis

MYOKAI Fumio, FUJITA Naoko, NAGAI Atsushi, ISOSHIMA Osamu, GOTO Hiroyuki, HONGYO Hiroshi, CHIHARA Toshihiro, SHIMIZU Naoko, TANIMOTO Ichiro, OHYAMA Hideki, SATO Nobuhiko, TAKASHIBA Shogo, KOBAYASHI Yoshitomo, MIYAMOTO Manabu, KURIHARA Hidemi, MURAYAMA Yoji

The Japanese Journal of Conservative Dentistry 38(1) 180-188 Feb 1995

Two genotypes of high-molecular-weight fimbriae-like protein in A. actinomycetemcomitans

SHIMIZU Akemi, MAEDA Hiroshi, KOKEGUCHI Susumu, FUJIMOTO Chiyo, MURAUCHI Toshimitsu, NISHIMURA Fusanori, FUKUI Kazuhiro, TAKASHIBA Shogo

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 47 May 2004

A Case of Periodontal Treatment in a Patient with Severe Aplastic Anemia

OYAIZU K., MINESHIBA F., MINESHIBA J., TAKAYA H., KONO T., CHIHARA T., ARAI H., NISHIMURA F., TAKASHIBA S.

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 47 May 2004

Microarray Analysis of Gene Expression Changes in Cultured Human Periodontal Ligament Fibroblasts by Mechanical Stress

YAMASHIRO Keisuke, HIRATSUKA Koichi, MYOKAI Fumio, SENOO Kyoko, TAKASHIBA Shogo, ABIKO Yoshimitsu

日本歯周病学会会誌 46 Apr 2004

A study to characterize molecules associated with HLA-DR molecules on human fibroblasts

YOSHIZAWA Sayuri, NISIMURA Fusanori, MEGURO Michio, TAKEUCHI Kazu, OHYAMA Hideki, TAKASHIBA Shogo

日本歯周病学会会誌 46 Apr 2004

A Case of Intentional Replantation for a Tooth with Infected Periodontal Ligament and Cementum

YAMASAKI Taishi, KONO Takayuki, SHIMIZU Akemi, MYOKAI Fumio, ARAI Hideo, NISHIMURA Fusanori, MURAYAMA Yoji, TAKASHIBA Shogo

日本歯科保存学雑誌 47(1) 31-36 Feb 2004

Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice

Experimental and Molecular Pathology 2004

Periodontitis and Systemic Disease : On the Basis of Periodontitis Pathogenesis

MURAYAMA Yoji, NISHIMURA Fusanori, IWAMOTO Yoshihiro, TAKASHIBA Shogo

Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 45,4,325-348(4) 325-348 Dec 2003

Scientific advances in periodontal disease are defining a new paradigm for dentistry and medicine. Strong evidence indicates that periodontitis enhances the risk of systemic disease.<BR>Periodontal disease is infectious and caused predominantly by...

Characterization of insertion sequence 1598 specific to Porphyromonas gingivalis (Pg) abscpss forming strains

MURAUCHI Toshimitsui, MAEDA Hiroshi, KOKEGUCHI Susumu, MAEDA Takemasa, SAWADA Koichi, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯科保存学雑誌 46 Oct 2003

A study on the rapid detection of CYP2C9*3 associated with low metabolic ability for phenytoin and wafarine

SOGA Yoshihiko, NISHIMURA Fuminori, SHIOMI Nobuyuki, YAMAGUCHI Mayumi, TAKASHIBA Shogo

日本歯科保存学雑誌 46 Oct 2003

Characteristic Antibody Response to Periodontal Bacteria in Recurrence of Periodontal Disease during Supportive Periodontal Treatment

SUGI Noriko, MYOKAI Fumio, KONO Takayuki, ARAI Hideo, CHIHARA Toshihiro, SHIMIZU Akemi, NISHIMURA Fusanori, TAKASHIBA Shogo

日本歯周病学会会誌 45 Sep 2003

High glucose enhances IL-6 induced VEGF expression via activation of gp130 mediated p44/42 MAPK-C/EBP signaling in human gingival fibroblasts

OMORI Kazuhiro, NARUISHI Koji, NISHIMURA Fusanori, YAMADA NARUISHI Hisa, YAMAGUCHI Mayumi, ARAI Hideo, TAKASHIBA Shogo

日本歯周病学会会誌 45 Sep 2003

Detection of Variation in HLA-DQB1 genes in patients with periodontal disease

OHYAMA Hideki, TAKASHIBA Shogo, MIYAMOTO Manabu, TAKAHASHI Keiso, KONO Takayuki, NAGAI Atsushi, KURIHARA Hidemi, MURAYAMA Yoji

Journal of the Japanese Society of Periodontology 35(3) 536-542 Sep 1993

Variation in the DQB 1 locus of the HLA gene, Which is involved in immune responsiveness, has been reported in some patients with early-onset periodontitis (EOF). The purpose of this study was to examine the distribution of subjects with gene vari...