1998年10月
T cell responses to 53-kDa outer membrane protein of porphyromonas gingivalis in humans with early-onset periodontitis
Human Immunology
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- 巻
- 59
- 号
- 10
- 開始ページ
- 635
- 終了ページ
- 643
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/s0198-8859(98)00064-0
- 出版者・発行元
- Elsevier BV
Patients with early-onset periodontitis (EOP) are susceptible to infection with periodontopathic bacteria, such as Porphyromonas gingivalis. Ag53, 53-kDa outer membrane protein of P. gingivalis, evokes strong humoral immune responses in EOP patients. In a first step to clarify how host immune cells recognize Ag53, we established Ag53-specific short-term T cell lines from 22 subjects including 6 EOP patients and 16 healthy donors, using overlapping peptides based on Ag53 amino acid sequences. All T cell lines from active EOP patients recognized a common region (p141-181, especially p141-161) on Ag53, while those from healthy donors showed heterogeneous specificity. p141-181 was not recognized by T cell lines established from EOP patients following therapy. A monoclonal antibody to HSA-DRB1 inhibited Ag53-induced proliferation of most of the T cell lines. Our observations suggest that, although antigen-presenting molecules are common in EOP patients and in healthy individuals, p141-161 includes a major T cell epitope(s) on Ag53 for active EOP patients but not for healthy individuals or inactive EOP patients. (C) American Society for Histocompatibility and Immunogenetics, 1998 Published by Elsevier Science Inc.
- リンク情報
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- DOI
- https://doi.org/10.1016/s0198-8859(98)00064-0
- CiNii Articles
- http://ci.nii.ac.jp/naid/30002637890
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/9757945
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000075880500005&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/s0198-8859(98)00064-0
- ISSN : 0198-8859
- CiNii Articles ID : 30002637890
- ORCIDのPut Code : 47542658
- PubMed ID : 9757945
- Web of Science ID : WOS:000075880500005