Jan, 2011
FGF-2 Stimulates Periodontal Regeneration: results of a multi-center randomized clinical trial
Journal of Dental Research
- Volume
- 90
- Number
- 1
- First page
- 35
- Last page
- 40
- Language
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1177/0022034510384616
- Publisher
- SAGE Publications
The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 µL of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.
- Link information
-
- DOI
- https://doi.org/10.1177/0022034510384616
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21059869
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000285577500007&DestApp=WOS_CPL
- URL
- http://journals.sagepub.com/doi/pdf/10.1177/0022034510384616
- URL
- http://journals.sagepub.com/doi/full-xml/10.1177/0022034510384616
- ID information
-
- DOI : 10.1177/0022034510384616
- ISSN : 0022-0345
- eISSN : 1544-0591
- Pubmed ID : 21059869
- Web of Science ID : WOS:000285577500007