TAKIGAWA Masaharu

J-GLOBAL         Last updated: Dec 24, 2018 at 21:14
 
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Name
TAKIGAWA Masaharu
URL
http://www.dent.okayama-u.ac.jp/arcocs/
Affiliation
Okayama University
Section
Science of Functional Recovery and Reconstruction,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Job title
Professor
Degree
(BLANK) D.D.S., Ph.D.(Osaka University)
Other affiliation
Okayama University

Research Areas

 
 

Academic & Professional Experience

 
1994
 - 
2005
 Professor,School of Dentistry,Dental School,Okayama University
 
2005
   
 
- Professor,School of Dentistry,Dental School,Okayama University
 
2005
   
 
- Professor,Science of Functional Recovery and Reconstruction,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University
 
1991
 - 
1994
 President,1991-1994 Associate Professor, Osaka University Dental School
 
1981
 - 
1991
 Senior Assistant Professor,1981-1991 Assitant Professor, Osaka University Dental School
 
1980
 - 
1982
 Researcher,University of Wisconsin
 

Education

 
 
 - 
1977
Graduate School, Division of Dental Research, Osaka University
 
 
 - 
1973
Faculty of Dentistry, Osaka University
 

Awards & Honors

 
2015
IADR Distinguished Scientist Award (Research in Oral Biology)
 
1997
Scientific Award for the study of Bone and Joint Diseases (the Japan Rheumatism Foundation)
 
1992
Scientific Award (Japanese Society of Bone Metablism)
 

Published Papers

 
Change in cellular localization of a rheumatoid arthritis-related antigen(RA-A47)with downregulation upon stimulation by inflammatory cytokines in chondrocytes.
Hattori, T., Kubota, S., Yutani, Y., Fujisawa, T., Nakanishi, T., Takahashi, K. and *Takigawa, M.
J. Cell. Physiol.   186 268-281   2001
Regulation of Human COL2A1 Gene Expression in Chondrocytes ; indentification of C-Krox-Responsive elements and modulation by phenoytpe alteration.
Ghayor, C., Herrouin, J.H., Chadjichristos, C., Ala-Kokko, L., *Takigawa, M., Pujol, J.P. and Galera, P
Journal of Biological Chemistry   275(35) 27421-27438   2000
Identity of urinary trypsin inhibitor-binding protein to link protein.
Kobayashi, H., Hirashima, Y., Wei Sun, G., Fujie, M., Nishida, T., *Takigawa, M. and Terao, T.
J. Biol. Chem.   275(28) 21185-21190   2000
Characterization of a mouse ctgf3''-UTR segment that mediates repressive regulation of gene expression.
Kondo, S., Kubota, S., Eguchi, T., Hattori, T., Nakanishi, T., Sugawara, T. and *Takigawa, M.
Biochem. Biophys. Res. Commun.   278(1) 119-124   2000
Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24(ctgf/hcs24)gene : Similarities to retroviral RNA-protein interactions.
Kubota, S., Kondo, S., Eguchi, T., Hattori, T., Nakanishi, T., Pomerantz, R.J. and Takigawa, M.
Oncogene   19 4773-4786   2000
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Nakanishi, T., Nishida, T., Shimo, T., Kobayashi, K., Kubo, T., Tamatani, T., Tezuka, K. and *Takigawa, M.
Endocrinology   141(1) 264-273   2000
Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
Nishida, T., Nakanishi, T., Asano, M., Shimo, T. and *Takigawa, M.
J. Cell. Physiol.   184 197-206   2000
Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis : Association with the extent of skin sclerosis and the severity of pulmonary fibrosis.
Sato, S., Nagaoka, T., Hasegawa, M., Tamatani, T., Nakanishi, T., *Takigawa, M. and Takehara, K.
J. Rheumatol.   27(1) 149-154   2000
Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologous serum derived from a chondrosarcoma patient ; a shared antigen of immunoresponses in cancer and autoimmune diseases.
Fujiwara, K., Udono, H., Kunisada, T., Kawai, A., Inoue, H., *Takigawa, M., Namba, M. and Nakayama, E.
Electrophoresis   20(17), 3335-42,   1999
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of temporomandibular joint osteoarthritis patients.
Kanyama, M., Kuboki, T., Kojima, S., Fujisawa, T., Hattori, T., *Takigawa, M. and Yamashita, A.
J. Orofacial Pain   14 20-30   1999
Role and interaction of connective tissue growth factor with transforming growth factor-β in persistent fibrosis : A mouse fibrosis model.
Mori, T., Kawara, S., Shinozaki, M., Hayashi, N., Kakinuma, T., Igarashi, A., *Takigawa, M., Nakanishi, T. and Takehara, K.
J. Cell. Physiol.   181(1) 153-159   1999
Connective tissue growth factor induces the proliferation, migration and tube formation of vascular endothelial cells in vitro and angiogenesis in vivo.
Shimo, T., Nakanishi, T., Nishida, T., Asano, M., Kanyama, M., Kuboki, T., Tamatani, T., Tezuka, K., Takemura, M., Matsumura, T. and *Takigawa, M.
J. Biochem.   126(1) 137-145   1999
Immunohistochemical localization of connective tissue growth factor in the rat central nervous system.
Kondo, Y., Nakanishi, T., *Takigawa, M. and Ogawa, N.
Brain Res.   834(1-2) 146-151   1999
Involvement of cis-acting repressive element(s) in the 3''-untranslated region of human connective tissue growth factor gene.
Kubota, S., Hattori, T. Nakanishi, T. and Takigawa, M.
FEBS Lett.   450 84-88   1999
Effect of pressure loading on interleukin-8 production in chondrocytes.
Kubo, T., Arai, Y., Takahashi, K., Ishida, T., Fujisawa, T., *Takigawa, M., Imanishi, J. and Hirasawa, Y.
Pathophysiology   6 35-39   1999
Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.
Fujisawa, T., Hattori, T., Takahashi, K., Kuboki, T., Yamashita, A. and *Takigawa, M.
J. Biochem.   125 966-975   1999
Direct adenovirus-mediated gene delivery to the temporomandibular joint in guinea-pigs.
Kuboki, T., Nakanishi, T., Kanyama, M., Sonoyama, W., Fujisawa, T., Kobayashi, K., Ikeda, T., Kubo, T., Yamashita ,A. and *Takigawa, M.
Arch. Oral Biol.   44(9) 701-709   1999
Detection of specific antibodies against human cultured chondrosarcoma(HCS-2/8) and osteosarcoma (Saos-2) cells in the serum of patients with osteoarthritis of the temporomandibular joint.
Kuboki, T., Hattori, T., Mizushima, T., Kanyama, M., Fujisawa, T., Yamashita, A. and *Takigawa, M.
Arch. Oral Biol.   44(5) 403-414   1999
Cartilaginous differentiation in the joint capsule.
Yutani, Y., Yano, Y., Ohashi, H., *Takigawa, M. and Yamano, Y.
J. Bone Miner. Metab.   17(1) 7-10   1999
Adenovirus vector-mediated gene transduction to chondrocytes : In vitro evaluation of therapeutic efficacy of transforming growth factor-β1 and heat shock protein 70 gene transduction.
Arai, Y., Kubo, T., Kobayashi, K., Ikeda, T., Takahashi, K., Takigawa, M., Imanishi, J. and Hirasawa, Y.
J. Rheumatol.   24 1787-1795   1999   [Refereed]
Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line(HCS-2/8).
Nishida,T., Nakanishi,T., Shimo,T., Asano,M., Hattori,T., Tamatani,T., Tezuka,K. and Takigawa,M.
Biochem. Biophys. Res. Commun.   247 905-909   1998   [Refereed]
Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line(HCS-2/8).
Hattori,T., Fujisawa,T., Sasaki,K., Yutani,Y., Nakanishi,T., Takahashi,K. and Takigawa,M.
Biochem. Biophys. Res. Commun.   245 679-683   1998   [Refereed]
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of billiary atresia.
Tamatani, T., Kobayashi, H., Tezuka, K., Sakamoto, S., Suzuki, K., Nakanishi, T., Takigawa, M. and Miyano, T.: Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
Biochem. Biophys. Res. Commun.   251 748-752   1998   [Refereed]
Increased expression of connective tissue growth factor in the infarct zone of experimentally induced myocardial infarction in rats.
Ohnishi, H., Oka, T., Kusachi, S., Nakanishi, T., Takeda, K., Nakahama, M., Doi, M., Murakami, T., Ninomiya, Y., Takigawa, M. and Tsuji, T.
J. Mol. Cell Cardiol.   30 2411-2422   1998
Demonstration of receptors for epidermal growth factor on cultured rabbit chondrocytes and regulation of their expression by various growth and differentiation factors.
Nishida,T., Nakanishi,T., Shimo,T., Asano,M., Hattori,T., Tamatani,T., Tezuka,K. and Takigawa,M.
Biochem.Biophys.Res.Commun.   183 14-20   1998   [Refereed]
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
Tamatani, T., Kobayashi, H., Tezuka, K., Sakamoto, S., Suzuki, K., Nakanishi, T., Takigawa, M. and Miyano, T
251, 748-752,   1998   [Refereed]
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
Shimo,T., Nakanishi,T., Kimura,Y., Nishida,T., Ishizeki,K., Matsumura,T. and Takigawa,M.
J. Biochem.   124 130-140   1998   [Refereed]
Overexpression of c-erbB-3 in various stages of human squamous cell carcinoma.
Funayama,T., Nakanishi,T., Takahashi,K., Taniguchi,S., Takigawa,M. and Matsumura, T
Oncology   55 161-167   1998   [Refereed]
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes.
Sasaki, K., Hattori, T., Fujisawa, T., Takahashi, K., Inoue, H., and Takigawa, M.
J. Biochem.   123 431-439   1998   [Refereed]
Isolation and characterization of a rheumatoid arthritis-specific antigen(RA-A47)from a human chondrocytic cell line(HSC-2/8).
Hattori,T., Fujisawa,T., Sasaki,K., Yutani,Y., Nakanishi,T., Takahashi,K. and Takigawa,M.
Biochem. Biophys. Res. Commun.   245 679-683   1998   [Refereed]
Shikonin an igredient of lithospermum erythrorhizon, inhibits angionenesis in vivo and in vitro.
Hisa,T., Kimura,Y., Takada,K., Suzuki,F. and Takigawa,M.
Anticancer Res.   18 783-790   1998   [Refereed]
Stimulatory effects of 4-methylcatechol, dopamine and levodopa on the expression of metallothionein-III(GIF)mRNA in immortalized mouse brain glial cells(VR-2g).
Aoki,C., Nakanishi,T., Sogawa,N., Ishii,K., Ogawa,N., Takigawa,M. an Furuta,H.
Brain Res.   792 335-339   1998   [Refereed]
Hydrostatic pressure induces expression of interleukin 6 and tumour necrosis factor α mRNAs in a chondrocyte-like cell line.
Takahashi, K., Kubo, T., Arai, Y., Kitajima, I., Takigawa, M., Imanishi, J. and Hirasawa, Y
Ann. Rheum. Dis.   57(4) 231-236   1998   [Refereed]
Adenovirus-mediated gene delivery to the joints of guinea pigs.
Ikeda, T., Kubo, T., Arai, Y., Nakanishi, T., Kobayashi, K., Takahashi, K., Imanishi, J., Takigawa, M. and Hirasawa, Y.
J. Rheum.   25 1666-1673   1998   [Refereed]
Expression of osteopontin in Meckel''s cartilage cells during phenotypic transdifferentiation in vitro, as detected by in situ hybridization and immunocytochemical analysis.
Ishizeki, K., Nomura, S., Takigawa, M., Shioji, H. and Nawa, T
Histochem. Cell Biol.   110 457-466   1998   [Refereed]
Peripheral type benzodiazepine receptor in T lymphocyte rich preparation.
Maeda, S., Miyawaki, T., Nakanishi, T., Takigawa, M. and Shimada, M.
Life Sciences   63(16) 1423-1430   1998   [Refereed]
Hydrostatic pressure influences mRNA expression of transforming growth factor-β1 and heat shock protein 70 in chondrocyte-like cell line.
Takahashi, K., Kubo, T., Kobayashi, K., Imanishi, J., Takigawa,M., AraiY., Hirasawa, Y.
J. Orthopaedic Res.   15 150-158   1997   [Refereed]
Coordinate change between complement C1s production and chondrocyte differentiation in vitro.
Nakagawa,K.,Sakiyama,H.,Fukusawa,T.,Matsumoto,M.,Takigawa,M.,Toyoguchi, T., Moriya, H.:
Cell Tissue Res.   289 299-305   1997   [Refereed]
Chondrocytes are regulated by cellular adhesion through CD44 and hyaluronic acid pathway.
Ishida, O., Tanaka, Y., Morimoto, I., Takigawa, M., Eto, S.
J. Bone Miner. Res.   12 1657-1663   1997   [Refereed]
Cloning of a mRNA preferentially expressed in chondrocytes in differential display PCR from a human chondrocytic cell line that is identical with connective tissue growth factor(CTGF) mRNA.
Nakanishi,T.,Kimura,Y.,Tamura,T.,Ichikawa,H.,Yamaai,Y.,Sugimoto,T., Takigawa,M.
Biochem. Biophys. Res. Commun.   234 206-210   1997   [Refereed]
Molecular characterization of integrin-procollagen C-propeptide interactions.
Davis, D., Tuckwell, D.S., Calderwood, D.A., Weston, S.A., Takigawa, M. Humphries, M.J.
Eur. J. Biochem.   246 274-282   1997   [Refereed]
The basic effect of IGF on chondrocytes.
Takigawa,M.,Kimura,Y. and Takahashi,K.
Clin. Pediatr. Endocrinol.   6(suppl10) 169-174   1997   [Refereed]
A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured entothelial cells and angio-genesis induced by B16 melanoma : its relation with cartilage-derived anti-tumor factor(CATF).
Takigawa, M., Shirai, E., Enomoto, M., Pan, H.-O., Suzuki, F., Shiio, T. and Yugari, Y.:
Biochem.Int.   14 357-364   1997   [Refereed]
Novel FNR homologues identified in four representative oral facultative anaerobes : Capnocytophaga ochracea, Capnocytophaga sputigena,Haemophilus aphrophilus,and Actinobacillus actinomycetemcomitans.
Hattori,T., Takahashi,K., Nakanishi,T., Ohta,H., Fukui,K., Taniguchi,S. and Takigawa,M.
FEMS Microbiol.Lett.   137 213-220   1996   [Refereed]
Vitamin D inhibits endothelial cell migration.
Hisa,T., Taniguchi,S., Tsuruta, D., Hirachi, Y., Ishizuka, S. and Takigawa,M.
Arch. Dermatol. Res.   288 262-263   1996   [Refereed]
Specific serum antibodies against membranous proteins of a human immortal chondrocytic cell line(HCS-2/8)in rheumatoid arthritis and their relation to the natural history of the disease.
Sakawa,A., Yutani,Y., Inui,K., Shimizu, A., Yamano,Y., Kinoshita,A., Suzuki,F., Hattori,T. and Takigawa,M
J. Bone Miner. Metab.   14 146-152   1996   [Refereed]
Establishment of an in vitro cell derived from human angiosarcoma.
Hisa,T., Taniguchi,S., Kakudo,K., Ichihashi,M., Takashima,T., Kato,Y., Hayakawa,R.,Takigawa,M.
Bull Cancer   83 589-591   1996   [Refereed]
Neurotrophin-3 increases the DNA-binding activities of several transcription factors in a mouse osteoblastic cell line.
Iwata,E., Nakanishi,T., Ogawa,N., Ohyama,K., Murakami,T. and Takigawa,M.
Biochim. Biophys. Acta   1311 85-92   1996   [Refereed]
Meckel''s cartilage chondrocytes in organ culture synthesize bone-type proteins accompanying osteocytic phenotype expression.
Ishizeki,K., Takigawa,M., Nawa,T., Harada,Y. and Suzuki,F.:
Anat.Embryol.   193 61-71   1996   [Refereed]
Mouse Meckel''s cartilage chondrocytes evoke bone-like matrix and further transform into osteocyte-like cells in culture.
Ishizeki,K., Takigawa,M., Nawa,T. and Suzuki,F.
Anat.Res.   245 25-35   1996   [Refereed]
Expression of c-fos gene inhibits proteoglycan synthesis in transfected chondrocyte.
Tsuji,M., Funahashi,S., Takigawa,M., Seiki,M., Fujii,K. and Yoshida, T.
FEBS Lett.   381 222-226   1996   [Refereed]
Interleukin-1 induces Matrix degradation and release of basic fibroblast growth factor in clutured rabbit articular chondrocytes via nitric oxide production : A possible mechanism of pathological neovascularization in arthritis.
Tamura, T., Makanishi, T., Kimura, Y., Hattori, T., Sasaki, K., Norimatsu, H., Takahashi, K. and Takigawa, M.: Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: A possible mechanism of pathological neovascularization in arthritis.
Endocrinology   137(9) 3729-3737   1996
Apoptosis in normal skin.
Hisa,T., Taniguchi,s., Kobayashi,H., Shigenaga,Y., Nomura,S. and Takigawa,M.
Acta Derm. Venereol.   75 412-413   1995
Demonstration of endothelin(ET) receptors on cultured rabbit chondrocytes and stimulation of DNA synthesis and calcium influx by ET-1 via its receptors.
Kinoshita,A., Tamura,T., Aoki,C., Nakanishi,T., Sobue, S., Suzuki,F., Takahashi,K. and Takigawa,M.(
Cell Biol.Int.   19 647-654   1995   [Refereed]
Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line,HCS-2/8.
Ohba,Y., Goto,Y., Kimura,Y., Suzuki,F., Hisa,T., Takahashi,K. and Takigawa,M.
Biochim.Biophys.Acta   1245 1-8   1995   [Refereed]
Proto-oncogene expression in a human chondrosarcoma cell line : HCS-2/8.
Zhu, J., Pan, H.O., Suzuki, F. and Takigawa, M.
Jpn.J.Cancer.Res.   85 364-371   1994   [Refereed]
Histatin as a synergistic stimulator with epidermal growth factor of rabbit chondrocyte proliferation.
Murakami, Y., Nagata, H. Shizukuishi,S., Nakashima,K., Okawa,T., Takigawa,M., Tsumemitsu,A.
Biochem.Biophys.Res.Commun.   198(1) 274-280   1994   [Refereed]
Changes in parathyroid hormone receptors during chondrocyte cytodifferentiation.
Iwamoto, M., Jikko, A., Murakami, H., Shimazu A., Nakashima, K., Iwamoto, M., Takigawa, M., Baba, H., Suzuki, F. and Kato, Y.
J.Biol.Chem.   269(25) 17245-17251   1994   [Refereed]
Conformation dependence of integrin-type(]G0002[) collagen binding.
Tuckwell, D.S., Ayad, S., Grant, M.E., Takigawa, M. and Humphries, M.J.:
J.Cell.Science.   107 993-1005   1994   [Refereed]
Establishment from a human chondrosarcoma of a new immortal cell line with abilities to form proteoglycan-rich cartilage nodules and to respond to insulin in vitro and high tumorigenicity in vivo.
Takigawa, M., Pan, H-O., Kinoshita, A., Tajima, K. and Takano, Y.
Int. J. Cancer   48 717-725   1991   [Refereed]
Physiological of vitamin A in growth cartilage cells : Low concentrations of retinoic acid strongly promote the proliferation of rabbit costal growth cartilage cells in culture.
Enomoto, M., Pan, H-O., Suzuki, F. and Takigawa, M.
J.Biochem.   107 743-748   1990   [Refereed]
Effects of tumor necrosis factor α on proliferaion and expression of differentiated phenotypes in rabbit costal chondrlcytes in culture.
Enomoto, M., Pan, H.-O., Kinoshita, A., Yutani, Y., Suzuki, F. and Takigawa, M
Calcif.Tissue.Int.   47 145-151   1990   [Refereed]
A clonal human chondrosarcoma cell line produces an anti-angiogenic antitumor factor.
Takigawa, M., Pan, H-O., Enomoto, M., Kinoshita, A., Nishida, Y., Suzuki, F., Tajima, K.
Anticancer Res.   10 311-316   1990   [Refereed]
Insulin-like growth factors (]G0001[) and (]G0002[) are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human. chondrosarcoma-derived chondrocyte ce・・・
Takigawa, M., Kinoshita, A., Enomoto, M., Asada, A. and Suzuki, F.
Endocrinology   138 4390-4400   1990   [Refereed]
Insulin-like growth factors (]G0001[) and (]G0002[) are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human. chondrosarcoma-derived chondrocy...
Tumor angiogenesis and polyamines : α-Difluoromethylornithine,an irrversible inhibitor of ornithine decarboxylase,inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.
Takigawa, M., Enomoto, M., Nishida, Y., Pan, H-O., Kinoshita, A., and Suzuki, F:
Cancer Res.   50 4131-4138   1990   [Refereed]
Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases(TIMP and TIMP-2).
Takigawa, M., Nishida, Y., Suzuki, F., Kishi, J., Yamashita, K., and Hayakawa, T.
Biochem.Biophys.Res.Commun.   171 1264-1271   1990   [Refereed]
The distribution of differentiated phenotypes of chondrocytes in osteoarthritic hip.
Yutani, Y., Asada, K., Takigawa, M., Omori, K., Shimazu, A.: The distribution of differentiated phenotypes of chondrocytes in osteoarthritic hip.
Jpn.J.Rheum.Joint Surg.   8 179-186   1989   [Refereed]
Demonstration of receptors for parathyroid hormone on cultured rabbit costal chondrocytes.
Enomoto, M., Kinoshita, A., Pan, H-O., Suzuki, F., Yamamoto, I. and Takigawa, M.
Biochim.Biophys.Res.Commun.   162 1222-1229   1989   [Refereed]
Establishment from mouse growth cartilage of clonal cell lines with responsiveness to parathyroid hormone,alkaline phos-phatase avtivity,and ability to produce an endothelial cell growth factor.
Takigawa, M., Shirai, E., Enomoto, M., Kinoshita, A., Pan, H.-O., Suzuki, F. and Yugari, Y.
Calcif.Tissue.Int.   45 305-313   1989   [Refereed]
Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes.
Takigawa, M., Tajima, K., Pan, H.-O., Enomoto, M., Kinoshita, A., Suzuki, F., Takano, Y. and Mori, Y.
Cancer Res.   49 3996-4002   1989   [Refereed]
Cartilage-derived anti-tumor factor(CATF) : Partial purification and correlation of inhibitory activity against tumor growth with anti-angiogenic activity.
Takigawa, M., Shirai, E., Enomoto, M., Hiraki, Y., Suzuki, F. and Yugari, Y.
J.Bone Mineral Metab.   6 83-92   1988   [Refereed]
Hydrocortisone stimulation of proliferration and glycosaminoglycan synthesis in rabbit craniofacial chondrocytes in vitro.
Takigawa, M., Takano, T., Nakagawa, K., Sakuda, M. and Suzuki, F.
Arch.oral Biol.   33 893-899   1988   [Refereed]
Chondrocytes dedifferentiated by serial monolayer culture form cartilage nodules in nude mice.
Takigawa, M., Shirai, E., Fukuo,, K., Tajima, K., Mori, Y., and Suzuki, F.
Bone Miner.   2 449-462   1987   [Refereed]
The effect of parathyroid hormone(1-34)on cyclic AMPlevel,ornithine decarboxylase acitivity and glycosaminoglycan synthesis of chondrocytes from mandibular cartilage,nasal septal cartilage,and spheno-occipital synchondrosis in culture.
Takano, T., Takigawa, M., Shirai, E., Nakagawa, K., Sakuda, M. and Suzuki, F.
J.Dent.Res.   66 84-87   1987   [Refereed]
Enhanced responsiveness to parathyroid hormone and induction of hanctional differentiation of cultured rabbit costal chondrocytes by a pulsed electromagnetic field.
Hiraki, Y., Endo, N., Takigawa, M., Asada, A., Takahashi, H. and Suzuki, F.
Biochim.Biophys.Acta   931 94-100   1987   [Refereed]
Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetra-decanoylphorbol-13-acetate in mouse epidermis.
Takigawa, M., Simsiman, R. C. and Boutwell, R. K.
Cancer Res.   46 106-112   1986   [Refereed]
Comparison of inhibition by a tumor promoter(12-O-tetradecanoylphorbol-13-acetate)of expression on the differentiated phenotype of chondrocytes in rabbit costal chondrocytes in culture with inhibition by retinoic acid.
Fukuo, K., Takigawa, M., Tajima, K., Enomoto, M., Kumahara, Y. and Suzuki, F.
J.Biochem.   99 385-396   1986   [Refereed]
Effects of various tumor promoters on expression of cartilage phenotypes in rabbit costal chondrocytes in culture.
Takigawa, M., Tajima, K., Fukuo, K., Fujiki, H. and Suzuki, F.
J.Biochem.   101 397-404   1986   [Refereed]
Effect of synthetic analogs and fragments of bovine parathyroid hormone on adenosine 3'',5''-monophosphate level,ornithine decarboxylase activity,and glycosaminoglycan synthesis in rabbit chondrocytes in culuture : Structure-activity relations.
Takano, T., Takigawa, M., Shirai, E., Suzuki, F. and Rosenblatt, M.
Endocrinology   116 2536-2542   1985   [Refereed]
Induction of spermidine/spermine N1-acetyltransferase by paratyroid hormone in rabbit costal chondrocytes in culture.
Matsui-Yuasa, I., Otani, S., Morisawa, S., Takigawa, M. and Suzuki, F.
J.Biochem.   97 387-390   1985   [Refereed]
Differentiation and de-defferrentiation of cultured chondorocytes : Increase in monomeric size of''cartilage specific''proteoglycans by dibutyryl cyclic AMP and complete inhibition of their synthesis by retinoic acid.
22) Hiraki, Y., Yutani, Y., Fukuya, M., Takigawa, M. and Suzuki, F
Biochem.Int.   10 267-272   1985   [Refereed]
Differential effects of parathyroid hormone and somatomedin-like growth factors on the sizes of proteoglycan monomers and their synthesis in rabbit costal chondrocytes in culture.
Hiraki, Y., Yutani, Y., Takigawa, M., Kato, Y. and Suzuki, F.
Biochim.Biophys.Acta   845 445-453   1985   [Refereed]
Simulation by glucocorticoids of the differentiated phenotype of chondrocytes and the proliferation of rabbit costal chondrocytes in culture.
Takano, T., Takigawa, M. and Suzuki, F.
J.Biochem.   97 1093-1100   1985   [Refereed]
Cartilage-derived anti-tumor factor(CATF)inhibits the proliferation of endothelial cells in culture.
Takigawa, M., Shirai, E., Enomoto, M., Hiraki, Y., Fukuya, M., Suzuki, F., Shiio, T. and Yugari, Y.
Cell.Biol.Int.Rep.   9 619-625   1985   [Refereed]
Studies on chondrocytes from mandibular condylar cartilage,nasal septal cartilage,and sphenoocciptal synchondrosis in culuture.1.Morphology,growth,glycosaminoglcan synthesis and responsiveness to bovine paratyroid hormone(1-34).
Takigawa, M., Okada, M., Takano, T., Ohmae, H., Sakuda, M. and Suzuki, F.
J.Dent.Res.   63 19-22   1984   [Refereed]
Cartilage derived anti-tumor factor(CATF) : A high morecular weight in cartilage extract inhibits tumor growth.
Suzuki, F., Takigawa, M., Hiraki, Y., Kato, Y., Fukuo, K. Shiio, T. and Yugari, Y.
J.Bone Mineral Metab.   2 231-235   1984   [Refereed]
Cytoskeleton and differnetitation : effects of cytochalasin B and colchicne on expression of the differentiated phenotype of rabbit costal chondrocytes in culture.
Takigawa, M., Takano, T., Shirai, E. and Suzuki, F
Cell Differ.   14 197-204   1984   [Refereed]
The difference between the effects of single and double applications of 12-O-tetrdecanoylphorbol-13-acetae,a potent tumor promoter,on polyamine metabolism and nucleic acid synthesis in mouse epidermis.
Takigawa, M., Simsiman, R. C. and Boutwell, R. K.
Carcinogenesis   4 5-7   1983   [Refereed]
Inhibition of mouse skin tumor promotion and of tumor promoter stimulated mouse epidermal polyamine biosynthesis by α-difluoromethylornithine.
Takigawa, M., Verma, A. K., Simsiman, R. C. and Boutwell, R. K.
43 3732-3738   1983   [Refereed]
urification of 12-O-tetra-decanoylphorbol-13-acetate-induced ornithine decarboxylase from mouse epidermis.
Perrella, F.W., Takigawa, M. and Boutwell, R.K.
15 885-889   1983   [Refereed]
Inhibition of polyamine synthesis and proliferation in mouse L cells by DL-α-hydrazino-δ-aminovaleric acid,an inhibitor of ornithine decarboxylase.
Gohda, E., Takigawa, M., Inoue, H., Kato, Y., Daikuhara Y. and Takeda, Y.
J.Biochem.   94 97-106   1983   [Refereed]
Role of polyamines in expression of the differntiated phenotype of chondrocytes : Effect of DL-α-hydrazino-δ-aminovaleric acid(DL-HAVA),an inhibitor of ornithine decarboxylase,on chondrocytes treated with parathyroid hormone.
Takano, T., Takigawa, M. and Suzuki, F.
J.Biochem.   93 591-598   1983   [Refereed]
A bioassay for parathyroid hormone using rabbit costal chondrocytes in culture.
Takano, T., Takigawa, M. and Suzuki, F.
Jpn.J.Oral.Biol.   25 394-397   1983   [Refereed]
Restoration by parathyroid hormone and dibutyryl cyclic AMP expression of the differentiated phenotype of chondrocytes inhibited by a tumor promoter,12-O-tetradecanylphobol-13-acetae.
Takigawa, M., Fukuo, K., Takano, T. and Suzuki, F.
Cell Differ.   13 283-291   1983   [Refereed]
Purification of 12-O-tetra-decanoylphorbol-13-acetate-induced ornithine decarboxylase from mouse epidermis.
Perrella, F.W., Takigawa, M. and Boutwell, R.K.
Int.J.Biochem.   15 885-889   1983   [Refereed]
Polyamine biosynthesis and skin tumor promotion : Inhibition of 12-O-tetradecanoylphorbol-13-acetate promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase, α-difluoromethylornithine.
Takigawa, M., Verma, A. K., Simsiman, R. C. and Boutwell, R. K.
Biochem.Biophys.Res.Commun.   105 969-976   1982   [Refereed]
Simulation of the initial stage of endochondral ossification : In vitro sequential culture of growth-cartilage cells and bone marrow cells.
Suzuki, F., Takase, T., Takigawa, M., Uchida, A. and Shimomura, Y.
Proc.Natl.Acad.Sci.U.S.A.   78 2368-2372   1981   [Refereed]
Role of polyamines in expression of the defferentiated phenotype of chondrocytes in culture.
Takano, T., Takigawa, M. and Suzuki, F.
Med.Biol.   59 423-427   1981   [Refereed]
Restoration by cyclic AMP of the differentiated phenotype of chondrocytes from dedifferntiated cells pretreated with retinoids.
Takigawa, M., Takano, T. and Suzuki, F.
Mol.Cell.Biochem.   42 145-153   1981   [Refereed]
Changes in polyamine metabolism of rat liver after administration of D-galactosamine : Favorable effects of putrescine administration on galactosmaine-induced hepatic injury.
Daikuhara, Y., Tamada, F., Takigawa, M., Takeda, Y. and Mori, Y.
Gastroenterology   77 123-132   1980   [Refereed]

Misc

 
Novel methods for the study of cell-collagen interactions.
Biochem.Soc.Trans.   19 370S

Books etc

 
CCN in Encyclopedia of Signaling Molecules (Choi E ed),. 2nd edition
Kubota, S. and Takigawa, M. (Part:Contributor)
Springer   2018   
CCN Proteins: Methods and Protocols
Takigawa, M. (Part:Editor)
2017   
CCN Proteins in Health and Disease
Perbal, A., Takigawa, M. and Perbal, B.
2010   
Roles of CCN2/CTGF in the control of growth and regeneration. in CCN Proteins : A New Family of Cell Growth and Differentiation Regulators
Takigawa M, Nishida T and Kubota S
2005   
CCN Proteins: A New Family of Cell Growth and Differentiation Regulators
Perbal, B. and Takigawa, M (Part:Editor)
Imperial College Press   2005   
The CCN family of proteins: An overview. in CCN Proteins:A New Family and Differentiation Regulators
TAKIGAWA Masaharu
1995   
Observations on the mechanism of skin tumor promotion by phorbol esters.
Cellular Inter-actions by Environmental Tumor Promoter,Edited by H.Fugiki,E Heker.R.E.Moor,T.Sugimura and I.B.Weinstein,Japan Sci.Soc.Press VNU Science Press   
Physiological roles of connective tissue growth factor(CTGF/Hcs24) : promotion of endochondral ossification, angiogenesis and tissue remodeling.
In Tissue Engineering for Therapeutic Use   
The CCN proteins - The CCN family of proteins: an overview.
In CCN Proteins: A New Family of Cell Growth and Differentiation Regulators   
Evidence that an elevated level of ornithine decarboxylase may be essential to tumor promotion by phorbol esters.
Polyamines : Basic and Clinical Aspects(eds.K.Imahori,F.Suzuki,O.Suzuki,& U.Bachrach)VNU Science Press   
Induction of ornithine decarboxylase and spermidine/spermine N1-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture.
Polyamines : Basic and Clinical Aspects(eds.K.Imahori,F.Suzuki,O.Suzuki,& U.Bachrach)VNU Science Press   
The role of polyamines in restoration of the differentiated phenotype of chondrocytes from de-differentiated cells pretreated with retinoic acid and a tumor promoter.
Polyamines : Basic and Clinical Aspects(eds.K.Imahori,F.Suzuki,O.Suzuki,& U.Bachrach)VNU Science Press   
Retionoids as inhibitors of tumor promotion.
Retinoids : New Trends in Research and Therapy(ed.J.H.Saurat)Kargel   
Sensitization of rabbit costal chondrocytes to parathyroid hormone by pulsing electro-magnetic field stimulation.
Bioelectrical Repair and Growth(eds.E.Fukuda,S.Inoue,T.Sakou,H.Takahashi & N.Tsuyama)Nishimura Shoten   
Cytochemical and biochemical approches to masticatory system.
Mechanobiological Research on the Masticatory System(ed.K.Kubota)VEB Verlage fur Medizin und Biologie   
Polyamines and angiogenesis : Inhibition of tumor angiogenesis by the irreversible inhibitor of ornithine decarboxylase,α-difluoromethyl-ornithine.
Proccedings of 1989 International Symposium on The Biology and Chemistry of Polyamines(eds.I.D.Algranati & T.Oshima)ICSU Press   
Parathyroid hormone-responsive clonal cell lines from mouse growth cartilage.
New Action of Parathyroid Hormone(ed.Massry,S.G.)Plenum Publishing Corp.