Misc.

2008

Management of Childhood-onset Epilepsy Evaluated with a Long-term Follow-up Study

E
  • Ohtsuka Yoko
  • ,
  • Kobayashi Katsuhiro
  • ,
  • Namba Masanori
  • ,
  • Endoh Fumika
  • ,
  • Oka Makio
  • ,
  • Yoshinaga Harumi

Volume
1
Number
1
First page
21
Last page
29
Language
English
Publishing type
DOI
10.3805/eands.1.21
Publisher
JAPAN EPILEPSY SOCIETY

Purpose: While many patients with childhood-onset epilepsy go into remission before reaching adulthood, a significant number of patients continue to suffer from refractory epilepsy. The purpose of this study was to clarify the long-term outcome of childhood-onset epilepsies.<BR>Subjects and Methods: We retrospectively studied 445 adult patients with childhood-onset epilepsies who were still being treated at the Department of Child Neurology, Okayama University Hospital.<BR>Results: Age at onset of epilepsy was < 7 years in 66% of the patients; 7 to 14 years in 30%; and 15 to 19 years in 5%. We classified the subjects into three groups: Group PE (289 patients) with partial epilepsy; Group GE (60 patients) with generalized epilepsy; Group RE (70 patients) consisting of patients with a history of West syndrome, Lennox-Gastaut syndrome, Doose syndrome and related epileptic syndromes; and 26 other unclassified cases. At follow-up, frequent seizures (≥ per month) were observed in 26%, 13% and 63% of patients in Groups PE, GE and RE, respectively. Of 168 patients in remission across these three groups, AEDs were discontinued or being reduced in 21% each, while 36% had experienced relapse of seizures, mainly caused by AED withdrawal.<BR>Discussion: This study indicated that these adult patients could be classified into two types: patients who still have frequent seizures even after reaching adulthood, and patients in remission or with rare seizures. For long-term management of these patients, an efficient system with cooperation between medical and comedical staff, and a comprehensive care system are essential.

Link information
DOI
https://doi.org/10.3805/eands.1.21
CiNii Articles
http://ci.nii.ac.jp/naid/130000061488
URL
https://jlc.jst.go.jp/DN/JALC/00315256109?from=CiNii
URL
http://search.jamas.or.jp/link/ui/2009248346
ID information
  • DOI : 10.3805/eands.1.21
  • ISSN : 1882-5567
  • CiNii Articles ID : 130000061488

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