MISC

1999年1月

Carrier-mediated absorption of salicylic acid from hamster cheek pouch mucosa

JOURNAL OF PHARMACEUTICAL SCIENCES
  • N Utoguchi
  • ,
  • Y Watanabe
  • ,
  • Y Takase
  • ,
  • J Suzuki
  • ,
  • M Matsumoto

88
1
開始ページ
142
終了ページ
146
記述言語
英語
掲載種別
DOI
10.1021/js970412e
出版者・発行元
AMER PHARMACEUTICAL ASSN

Previously, we found that monocarboxylic acids undergo carrier-mediated transport in primary cultures of oral mucosal epithelial cells.(1) In this study, we investigated whether carrier-mediated absorption of a monocarboxylic acid from the oral mucosa occurs in vivo. Salicylic acid was administered to hamster cheek pouch. At predetermined intervals, the concentration of salicylic acid in the fluid remaining in the cheek pouch lumen and the blood salicylic acid concentration were determined. The absorption of salicylic acid was saturable at high salicylic acid concentrations. Sodium azide,a metabolic inhibitor, and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP), a protonophore, significantly inhibited the absorption of salicylic acid but not the absorption of salicylamide from the oral mucosa. Various monocarboxylic acids inhibited the absorption of salicylic acid, whereas dicarboxylic acids had no such effect. Transfer of [C-14]salicylic acid from the cheek pouch mucosa to the systemic circulation was observed, and the blood [C-14]salicylic acid concentration in the case of coadministration with propionic acid was significantly lower than that in the case of no propionic acid coadministration. These results show that monocarboxylic acids undergo carrier-mediated absorption from the hamster cheek pouch mucosa.

リンク情報
DOI
https://doi.org/10.1021/js970412e
CiNii Articles
http://ci.nii.ac.jp/naid/80010898547
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9874716
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000077960100022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1021/js970412e
  • ISSN : 0022-3549
  • CiNii Articles ID : 80010898547
  • PubMed ID : 9874716
  • Web of Science ID : WOS:000077960100022

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