2010年
Chlorination by-products of fenitrothion
WATER SCIENCE AND TECHNOLOGY
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- 巻
- 62
- 号
- 1
- 開始ページ
- 85
- 終了ページ
- 91
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2166/wst.2010.264
- 出版者・発行元
- IWA PUBLISHING
The mutagens produced through chemical reaction between chlorine and the insecticide fenitrothion were studied by using a quadrupole GC-MS. The mutagenicity and the mutagen formation potential (MFP) of the identified by-products were evaluated by the Ames assay (preincubation method) using Salmonella typhimurium TA100 without exogenous activation by S9 mix (TA100-S9). Before conducting GC/MS analyses, six compounds were presumed to be produced in chlorinated fenitrothion. These compounds were confirmed to be produced by the GC/MS analyses, but none of them were mutagenic. One of the chlorination by-products, 3-methyl-4-nitrophenol, has 19 times greater MFP than that of fenitrothion. This result suggests that a major mutagen in chlorinated fenitrothion will be produced via a chemical reaction between chlorine and 3-methyl-4-nitrophenol.
- リンク情報
- ID情報
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- DOI : 10.2166/wst.2010.264
- ISSN : 0273-1223
- PubMed ID : 20595757
- Web of Science ID : WOS:000279810700012