Risuke Mizuno

Profile Information

Affiliation: Okayama University of Science

Degree: PhD(Shinshu University)
DVM

J-GLOBAL ID: 200901094707308012
researchmap Member ID: 1000187938

External link: http://www.vet.ous.ac.jp/seminar/yakuri/

Research Areas

Research History

2018 - Present

Okayama University of Science
2015 - 2018

Faculty of Health Sciences, Tsukuba International University
2014 - 2015

Graduate School of Agricultural and Life Sciences, The University of Tokyo
2009 - 2014

Graduate School of Medicine, The University of Tokyo
2000

- 信州大学講師
1995 - 1997

ポスドク, 医学部, ニューヨーク医科大学
1995

- 信州大学助手

Education

Committee Memberships

Awards

2001

日本リンパ学会奨励賞
1996

AHA NY State Affiliate Fellowship

水野理介

Papers

Treatment with Ligilactobacillus murinus lowers blood pressure and intestinal permeability in spontaneously hypertensive rats

Masashi Mukohda, Takanori Yano, Toshiyasu Matsui, Sho Nakamura, Jiro Miyamae, Kensuke Toyama, Ryoji Mitsui, Risuke Mizuno, Hiroshi Ozaki

Scientific Reports, 13(1), Sep 14, 2023
Hypertension is linked to enhanced lymphatic contractile response via RGS16/RhoA/ROCK pathway.

Masashi Mukohda, Risuke Mizuno, Fumiyo Saito, Toshiyasu Matsui, Hiroshi Ozaki

American journal of physiology. Heart and circulatory physiology, 323(6) H1118-H1129, Dec 1, 2022
[Gut microflora and metabolic syndrome: new insight into the pathogenesis of hypertension].

Masashi Mukohda, Risuke Mizuno, Hiroshi Ozaki

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 157(5) 311-315, 2022
Streptococcal Exotoxin Streptolysin O Causes Vascular Endothelial Dysfunction Through PKCβ Activation.

Masashi Mukohda, Sho Nakamura, Kosuke Takeya, Akira Matsuda, Takanori Yano, Mihiro Seki, Risuke Mizuno, Hiroshi Ozaki

The Journal of pharmacology and experimental therapeutics, Aug 13, 2021
Streptolysin O: a novel mediator of endothelial dysfunction

Mukohda Masashi, Seki Mihiro, Nakamura Sho, Takeya Kosuke, Takanori Akira, Yano Takanori, Mizuno Risuke, Ozaki Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94 2-O-D3-2, 2021
High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese Population.

Yasuko Yoshida, Keisei Kosaki, Takehito Sugasawa, Masahiro Matsui, Masaki Yoshioka, Kai Aoki, Tomoaki Kuji, Risuke Mizuno, Makoto Kuro-O, Kunihiro Yamagata …

Nutrients, 12(11), Nov 12, 2020
A near-infrared spectroscopy (NIRS) device unveils oxygenation levels in skeletal muscle and brain of a conscious Harris’s Hawk (Parabuteo unicinctus)

Kimiaki Doi, Keisuke Hiwatashi, Makoto Yokosuka, Risuke Mizuno

Journal of Ornithology, 161(4) 1021-1024, Oct 1, 2020
Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency.

Wakako Kawarazaki, Risuke Mizuno, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Fumiko Kawakami-Mori, Shigeyoshi Oba, Takeshi Marumo, Toshiro Fujita

The Journal of clinical investigation, 130(8) 4152-4166, Aug 3, 2020 Peer-reviewed
Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hypertensive Rats.

Masashi Mukohda, Risuke Mizuno, Hiroshi Ozaki

Hypertension (Dallas, Tex. : 1979), 76(2) 598-606, Aug, 2020
加齢に伴う食塩感受性高血圧発症における腎血管性機序の検討

河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 大庭成嘉, 丸茂丈史, 藤田敏郎

日本腎臓学会誌, 62(4) 300-300, Jul, 2020
血管内皮における細胞内カルシウムセンサーSTIM1による血圧調節機構の解析

西本光宏, 水野理介, 藤田敏郎, 一色政志

日本高血圧学会総会プログラム・抄録集, 42回 222-222, Oct, 2019
Stromal interaction molecule 1 modulates blood pressure via NO production in vascular endothelial cells.

Mitsuhiro Nishimoto, Risuke Mizuno, Toshiro Fujita, Masashi Isshiki

Hypertension research : official journal of the Japanese Society of Hypertension, 41(7) 506-514, Jul, 2018 Peer-reviewed
Examiner's finger-mounted near-infrared spectroscopy is feasible to analyze cerebral and skeletal muscle oxygenation in conscious Chihuahuas

Keisuke Hiwatashi, Kimiaki Doi, Risuke Mizuno, Makoto Yokosuka

JOURNAL OF BIOMEDICAL OPTICS, 22(2) 26006, Feb, 2017 Peer-reviewed
STIM1は血管内皮細胞においてNO産生を介して血圧調節に関与する

西本光宏, 一色政志, 水野理介, 丸茂丈史, 河原崎和歌子, 鮎澤信宏, 上田浩平, 広浜大五郎, 藤田敏郎

日本内分泌学会雑誌, 92(3) 891-891, Jan, 2017 Peer-reviewed
Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice

Shoma Mikawa, Shohei Yamamoto, Md Shafiqul Islam, Noriyuki Kaji, Takahisa Murata, Risuke Mizuno, Hiroshi Ozaki, Masatoshi Hori

JOURNAL OF VETERINARY MEDICAL SCIENCE, 77(10) 1195-1199, Oct, 2015 Peer-reviewed
A High-Salt Diet Differentially Modulates Mechanical Activity of Afferent and Efferent Collecting Lymphatics in Murine Iliac Lymph Nodes

Risuke Mizuno, Masashi Isshiki, Nobuyuki Ono, Mitsuhiro Nishimoto, Toshiro Fujita

LYMPHATIC RESEARCH AND BIOLOGY, 13(2) 85-92, Jun, 2015 Peer-reviewed
A High Salt Diet Alters Pressure-Induced Mechanical Activity of the Rat Lymphatics with Enhancement of Myogenic Characteristics

Risuke Mizuno, Masashi Isshiki, Nobuyuki Ono, Mitsuhiro Nishimoto, Toshiro Fujita

LYMPHATIC RESEARCH AND BIOLOGY, 13(1) 2-9, Mar, 2015 Peer-reviewed
FRET-based sensor analysis reveals caveolae are spatially distinct Ca2+ stores in endothelial cells.

Masashi Isshiki, Mitsuhiro Nishimoto, Risuke Mizuno, Toshiro Fujita

Cell calcium, 54(6) 395-403, Dec, 2013 Peer-reviewed
High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice

Asuka Shiota, Yutaka Taketani, Yoichi Maekawa, Koji Yasutomo, Masataka Sata, Tohru Sakai, Risuke Mizuno, Masashi Isshiki, Hironori Yamamoto, Eiji Takeda

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 49(2) 109-114, Sep, 2011 Peer-reviewed
Head-down tilt posture elicits transient lymphocyte mobilization from the iliac, but not mesenteric, lymph nodes of rats

Shigeru Suzuki, Risuke Mizuno, Fumitaka Ikomi, Toshio Ohhashi

JOURNAL OF APPLIED PHYSIOLOGY, 105(5) 1595-1601, Nov, 2008 Peer-reviewed

Misc.

Lymphatic Contraction Was Enhanced In Spontaneously Hypertensive Rats.

Masashi Mukohda, Toshiyasu Matsui, Hiroshi Ozaki, Risuke Mizuno

HYPERTENSION, 76, Sep, 2020
Bacterial toxin, streptolysin O caused vascular endothelial dysfunction: Relationship between dysbiosis and hypertension

Mukohda Masashi, Nakamura Sho, Takeya Kosuke, Matsuda Akira, Yano Takanori, Mizuno Risuke, Ozaki Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 2-O-061, 2020
Thoracic duct function was impaired in spontaneously hypertensive rat

Mukohda Masashi, Mizuno Risuke, Ozaki Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 2-YIA-25, 2019
Feasibility of measuring urine glucose concentrations by a digital meter in dogs and cats

K. Hiwatashi, K. Doi, R. Mizuno, M. Yokosuka

Journal of Pet Animal Nutrition, 21(2) 102-105, 2018
A FRET-based Sensor Detects Caveolae as Spatially Distinct Ca2+Stores in Endothelial Cells

Masashi Isshiki, Risuke Mizuno, Mitsuhiro Nishimoto, Toshiro Fujita

CIRCULATION, 126(21), Nov, 2012
High Salt Inhibits Lymphatic Transport Function Through Regulation Of Na plus -K plus -ATPase Activity

Risuke Mizuno, Masashi Isshiki, Mitsuhiro Nishimoto, Toshiro Fujita

CIRCULATION, 126(21), Nov, 2012
Roles of reactive oxygen species (ROS) in the regulation of pump activity of isolated rat lymph vessels

Mizuno Risuke, Ono Nobuyuki, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2008 190-190, 2008
Current topics of the lymphatic functions: pump activity and permeability of lymph vessels

Mizuno Risuke, Ikomi Fumitaka, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2007 6-6, 2007
Accumulation of colloidal particles in rabbit popliteal lymph nodes in vivo

Ikomi Fumitaka, Nagai Takashi, Suzuki Shigeru, Mizuno Risuke, Kawai Yoshiko, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2006 131-131, 2006
Effects of trypsin on effective permeability of 77KDa dextran in isolated lymph vessels

Mizuno Risuke, Ono Nobuyuki, Kawai Yoshiko, Ikomi Fumitaka, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2006 132-132, 2006
Uptake of micro- and nano-particles from interstitial space into lymphatic system

Suzuki Shigeru, Ikomi Fumitaka, Nagai Takashi, Mizuno Risuke, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2006 132-132, 2006
Development of in vitro assay system for evaluating macromolecular permeability through cultured rat lymphatic endothelial cells

Kawai Yoshiko, Mizuno Risuke, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2006 133-133, 2006
Effect of Nitric Oxide and Prostaglandin of Microcirculation in Rat Sciatic Nerves

SAKAI Noriko, MIZUNO Risuke, ONO Nobuyuki, KATO Hiroyuki, OOHASHI Toshio

16(2) 97-98, Dec 1, 2005
リンパ行性癌転移とリンパ管の生理学 (特集リンパ管新生の分子機構と病態)

伊古美文隆, 水野理介, 河合佳子

細胞, 37(5) 18-21, May, 2005
Culture of rat lymphatic endothelial cells isolated from afferent and efferent lymph vessels and their biological properties

Y Kawai, R Mizuno, F Ikomi, T Ohhashi

FASEB JOURNAL, 19(4) A168-A168, Mar, 2005
IIB-10 大腸癌におけるリンパ管新生とその臨床病理学的意義(腫瘍,一般演題発表,第46回日本組織細胞化学会総会・学術集会)

大町俊哉, 河合佳子, 水野理介, 野見山哲生, 大橋俊夫, 中山淳

日本組織細胞化学会総会プログラムおよび抄録集, (46) 99-99, 2005
High oxygen tension constricts rat sciatic nervous arterioles in vivo

Sakai Noriko, Mizuno Risuke, Ono Nobuyuki, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2005 S94-S94, 2005
Culture of rat lymphatic endothelial cells isolated from lymph vessels their biological properties

Kawai Yoshiko, Mizuno Risuke, Ikomi Fumitaka, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2005 S92-S92, 2005
Lymph dynamics and passage of lymphocytes in isolated lymph nodes of rats

Mizuno Risuke, Kawai Yoshiko, Sakai Noriko, Ono Nobuyuki, Ikomi Fumitaka, Ohhashi Toshio

Proceedings of Annual Meeting of the Physiological Society of Japan, 2005 S94-S94, 2005
Development for Investigation of Microcirculation in Rat Sciatic Nerves

WADA Noriko, MIZUNO Risuke, ONO Nobuyuki, HORIUCHI Hiroshi, KATO Hiroyuki, OOHASHI Toshio

15(2) 87-88, Dec 1, 2004

Professional Memberships

Research Projects

腎臓排出リンパ管の局所RASは食塩感受性高血圧症の病態に関連する

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

水野理介, 向田昌司
Lymphatic vessels acquires inflammatory abilities

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Ozaki Hiroshi
Development of new treatment for reproductive disorders with myosin phosphatase inhibitory factor

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Hori Masatoshi
Lymphatic system facilitates amyloid beta clearance for dementia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Risuke Mizuno
Developmental research for treatment of salt-sensitive hypertension by regulation of lymphatic Na+ pump

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Mizuno Risuke
Development of a new treatment for salt-sensitive hypertension by improvement of the lymphatic system

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

MIZUNO Risuke
Improvement of peripheral microcirculation by a new gas transmitter delivery

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MIZUNO Risuke, ISSHIKI Masashi
Imaging of intracellular dynamics of Ca^<2+>-influx-associated molecules and its physiological significance in endothelial cells.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

ISSHIKI Masashi, MIZUNO Risuke
組織間隙からセンチネルリンパ節への特異的な薬物集積システムの開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, 2007 - 2010

伊古美文隆, 水野理介, 河合佳子, 保坂佳代子
Basic and clinical research for evaluating micro-environmental changes in sentinel lymph node produced by micro-metastasis of carcinoma cell.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2007 - 2009

OHHASHI Toshio, KAWAI Yoshiko, NAGAI Takashi, IKOMI Fumitaka, MIZUNO Risuke, HOSAKA Kayoko
リンパ管壁への薬物伝達システムによるリンパ管機能再生に関する開発的研究

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, 2008 - 2008

水野理介
Developmental study for hybrid artificial lymph vessels:its potential role of permeability

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2007

MIZUNO Risuke, IKOMI Fumitaka, KAWAI Yoshiko, SUGIHARA Nobuhiro
Basic research of lymphangiogenesis for new treatment of lymph edema

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2007

KAWAI Yoshiko, IKOMI Fumitaka, MIZUNO Risuke
前哨リンパ節(SLN)への癌転移因子解明のリンパ学的研究

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2005 - 2006

大橋俊夫, 伊古美文隆, 水野理介, 河合佳子
Development of drug delivery system (DDS) target for the lymphatic system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2005

IKOMI Fumitaka, MIZUNO Risuke
前哨リンパ節への癌転移因子解明のリンパ生理学的研究

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2003 - 2004

大橋俊夫, 伊古美文隆, 水野理介, 河合佳子
人工リンパ管開発のための培養リンパ管細胞を用いた基礎的研究

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2003 - 2004

水野理介
癌のリンパ行性転移モデルを利用した組織間隙・リンパ循環間の連繋機能の評価研究

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2001 - 2002

水野理介
Physiome and pathophysiome research projects for studying cooperative functions of interstitial space and lymphatic system.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)., Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

OHHASHI Toshio, MIZUNO Risuke, IKOMI Fumitaka
DEVELOPMENT OF A NEW EXPERIMENTAL APPARATUS FOR STUDYING OF MECHANICAL ACTIVITY OF ISOLATED ARTERIOLES.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1995 - 1996

OHHASHI Toshio, MIZUNO Risuke, YOKOYAMA Shin, IKOMI Fumitaka, WANG Hijie

Profile Information

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Professional Memberships

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