Etsuji Okada - My portal - researchmap

Profile Information

Affiliation: Associate Professor, Graduate School of Engineering Department of Chemical Science and Engineering, Kobe University

Degree: 理学博士(神戸大学)

J-GLOBAL ID: 200901056851680253
researchmap Member ID: 1000188114

External link: http://www2.kobe-u.ac.jp/~okaetsu/cx32index.html

Research Interests

12

Research Areas

2

Education

1

- Mar, 1986

Graduate School of Science and Technology, Kobe University

Papers

46

Selective Aromatic Nucleophilic Substitution of 4-Dimethylamino-2-Methoxy-3-(Trifluoroacetyl)Quinoline with Alcohols – Dft Calculation Study

OTA NORIO, HARADA YUSUKE, KAMITORI YASUHIRO, OKADA ETSUJI

Heterocycles, 101(1), Jan, 2020 Peer-reviewed
SELECTIVE AROMATIC NUCLEOPHILIC SUBSTITUTION OF 4-(DIMETHYLAMINO)-2-METHOXY-3-(TRIFLUOROACETYL)QUINOLINE WITH THIOLS - DFT CALCULATION STUDY

OTA NORIO, HARADA YUSUKE, KAMITORI YASUHIRO, OKADA ETSUJI

Heterocycles, 99(1) 694, Jan, 2019 Peer-reviewed
Computational Study for the Aromatic Nucleophilic Substitution Reaction on 1-Dimethylamino-2,4-bis(trifluoroacetyl)naphthalene with Amines

NORIO OTA, TOMOHIRO NAKADA, TAKUMI SHINTANI, YASUHIRO KAMITORI, ETSUJI OKADA

Int. J. Org. Chem., 8 273, Aug, 2018 Peer-reviewed
COMPUTATIONAL STUDY FOR THE SELECTIVE AROMATIC NUCLEOPHILIC SUBSTITUTION ON 4-DIMETHYLAMINO- 2-METHOXY-3-TRIFLUOROACETYLQUINOLINE

NORIO OTA, SHOTA SASAKAWA, YASUHIRO KAMITORI, ETSUJI OKADA

Heterocycles, 97(1) 451, Jan, 2018 Peer-reviewed
FACILE AND CONVENIENT SYNTHESES OF FLUORINE-CONTAINING PYRIMIDO [5,4-c]QUINOLINES AND BENZO [h][1,6]NAPHTHYRIDINES BY CONDENSATION REACTION OF 2-METHOXY-3-TRIFLUOROACETYL-4-QUINOLYLAMINE WITH ALDEHYDES AND KETONES

Mizuki Hatakenaka, Etsuji Okada

HETEROCYCLES, 94(1) 102-116, 2017 Peer-reviewed
EFFICIENT SYNTHESIS OF FLUORINE-CONTAINING DIBENZO [b,h][1,6]NAPHTHYRIDINES AND THIOCHROMENO[3,2-c]-QUINOLINES USING HIGHLY CHEMOSELECTIVE NUCLEOPHILIC SUBSTITUTION REACTION OF 4-DIMETHYLAMINO-2-METHOXY-3-TRIFLUOROACETYLQUINOLINE

Etsuji Okada, Mizuki Hatakenaka, Yoshinori Takezawa, Keisuke Iwakuni

HETEROCYCLES, 95(1) 322-341, Jan, 2017 Peer-reviewed
FACILE SYNTHESES OF FLUORINE-CONTAINING 4-METHOXY-PYRAZOLO[4,3-c]QUINOLINES AND 6-METHOXY-1,4-DIAZEPINO-[6,5-c] QUINOLINES

Mizuki Hatakenaka, Satoru Adachi, Etsuji Okada

HETEROCYCLES, 92(5) 936-943, May, 2016 Peer-reviewed
UNEXPECTED HIGHLY CHEMOSELECTIVE NUCLEOPHILIC SUBSTITUTION REACTION OF 4-DIMETHYLAMINO-2-METHOXY-3-TRIFLUOROACETYLQUINOLINE WITH VARIOUS NUCLEOPHILES

Etsuji Okada, Mizuki Hatakenaka, Yoshinori Takezawa, Keisuke Iwakuni

HETEROCYCLES, 93(2) 474-481, Apr, 2016 Peer-reviewed
COMPUTATIONAL STUDY FOR 1,5-SIGMATROPIC HYDROGEN SHIFT ON TRIFLUOROMETHYLAZADIENE DERIVATIVES - THE KEY STEP IN THE SYNTHESIS OF FLUORINE-CONTAINING OXAZINES -

Norio Ota, Yasuhiro Kamitori, Takashi Okuda, Etsuji Okada

HETEROCYCLES, 93(1) 243-249, Apr, 2016 Peer-reviewed
FACILE AND CONVENIENT SYNTHESES FOR FLUORINE- CONTAINING PYRAZOLO[4,3-c]QUINOLINES, ISOXAZOLOQUINOLINES, AND 1,4-DIAZEPINO[6,5-c]QUINOLINES

Okada Etsuji, Hatakenaka Mizuki, Sakaemura Takusi

Heterocycles, 90(2) 1072, Feb, 2015 Peer-reviewed
EFFICIENT SYNTHESES OF FLUORINE-CONTAINING PYRIMIDO[5,4-c]QUINOLINES AND BENZO [h] [1,6]NAPHTHYRIDINES BY CONDENSATION REACTIONS OF 3-TRIFLUOROACETYLQUINOLIN-4-AMINE WITH ALDEHYDES AND KETONES

Etsuji Okada, Mizuki Hatakenaka, Shiro Nakano, Takushi Sakaemura, Takashi Mori, Terukazu Terauchi

HETEROCYCLES, 89(10) 2303-2317, Oct, 2014 Peer-reviewed
A FACILE AND CONVENIENT SYNTHETIC METHOD FOR FLUORINE-CONTAINING DIBENZO[b,h][1,6]NAPHTHYRIDINES, THIOCHROMENO[3,2-c]QUINOLINES, AND CHROMENO[3,2-c]QUINOLINES

Etsuji Okada, Mizuki Hatakenaka, Masayuki Kuratani, Takashi Mori, Takuro Ashida

HETEROCYCLES, 88(1) 799-806, Jan, 2014 Peer-reviewed
Incorporation of a 3.(2,2,2-Trifluoroethyl)-γ-hydroxy-γ-lactam Motif in the Side Chain of 4.Aminoquinolines. Syntheses and AntimalarialActivities

Okada Etsuji, D. Cornut, H. Lemoine, O. Kanishchev, F. Albrieux, A. H. Beavogui, A.-L. Bienvenu, S. Picot, J.-P. Bouillon, M. Me.debielle

J. Med. Chem., 56 73, Oct, 2013 Peer-reviewed
A VERSATILE METHOD FOR THE SYNTHESIS OF FLUORINE-CONTAINING CHLOROQUINE ANALOGUES STARTING FROM 7-CHLORO-4-(N,N-DIMETHYLAMINO)QUINOLINE USING NUCLEOPHILIC N-N, N-S, AND N-O EXCHANGE REACTIONS

Okada Etsuji, Hatakenaka Mizuki, T. Ashida

Heterocycles, 87(12) 2614, Oct, 2013 Peer-reviewed
Incorporation of a 3-(2,2,2-Trifluoroethyl)-gamma-hydroxy-gamma-lactam Motif in the Side Chain of 4-Aminoquinolines. Syntheses and Antimalarial Activities

Damien Cornut, Hugues Lemoine, Oleksandr Kanishchev, Etsuji Okada, Florian Albrieux, Abdoul Habib Beavogui, Anne-Lise Bienvenu, Stephane Picot, Jean-Philippe Bouillon, Maurice Medebielle

JOURNAL OF MEDICINAL CHEMISTRY, 56(1) 73-83, Jan, 2013 Peer-reviewed
Computational Study on the Acid Catalyzed Reactions of Fluorine-Containing 2,4-Dialkoxy-3,4-dihydro-2H-pyrans with Aromatic Compounds

Norio Ota, Yasuhiro Kamitori, Ryusuke Shirai, Mizuki Hatakenaka, Etsuji Okada

Appl. Sci., Vol.2・pp.129, Feb, 2012 Peer-reviewed
A FACILE AND CONVENIENT METHOD FOR THE SYNTHESIS OF 6,8-BIS(TRIFLUOROACETYL)QUINOLIN-5-AMINES

Dai Shibata, Maurice Medebielle, Mizuki Hatakenaka, Etsuji Okada

HETEROCYCLES, 84(2) 1277-1284, Jan, 2012 Peer-reviewed
Simple syntheses of 3-trifluoroacetyl-4-quinolylamines, sulfides, and ethers starting from N,N-dimethyl-4-quinolylamine

Etsuji Okada, Mizuki Hatakenaka, Takushi Sakaemura, Naofumi Shimomura, Takuro Ashida

Heterocycles, 86(2) 1177-1185, 2012 Peer-reviewed
Computational study on acid catalyzed ring-opening reaction of 2,4-diethoxy-6-trifluoromethyl-3,4-dihydro-2H-pyran with thiols

Norio Ota, Yasuhiro Kamitori, Mizuki Hatakenaka, Etsuji Okada

Heterocycles, 86(1) 705-712, 2012 Peer-reviewed
Facile and Convenient Syntheses of Fluorine-Containing Pyrido[2,3-h]-quinazolines and 1,7-Phenanthrolines by Condensation Reactions of 6,8-Bis(trifluoroacetyl)quinolin-5-amine with Carbonyl Compounds

Mamoru Hinoshita, Dai Shibata, Mizuki Hatakenaka, Etsuji Okada

SYNTHESIS-STUTTGART, No.17・pp.2754(17) 2754-2760, Sep, 2011 Peer-reviewed

More

Misc.

3

新規芳香族求核置換反応の開発と生物活性含フッ素複素環化合物の高効率的合成への応用

岡田悦治

平成12年度～平成14年度科学研究費補助金基盤研究（C)(2)研究成果報告書, 未記入, 2003
新規生物活性含フッ素複素環化合物の高効率合成法の開発

岡田悦治

(財)長瀬科学技術振興財団研究報告集, 14,149-150, 2003
フッ素系液晶材料の開発－ナフタレン骨格を有する新規含フッ素複素環化合物の簡便合成

岡田悦治

神戸大学ベンチャー・ビジネス・ラボラトリー年報, 8,112-115, 2003

Books and Other Publications

1

第５版実験化学講座１３有機化合物の合成Ⅰ 炭化水素・ハロゲン化物

網井秀樹, 伊藤健兒, 井上将彦, 井上佳久, 宇根山健治, OKADA ETSUJI, 片桐利真, 北村二雄, 佐藤哲也, 芝田育也, 瀬恒潤一郎, 園田素啓, 高田十志和, 戸部義人, 古荘義雄, 前多肇, 益山新樹, 三浦雅博, 水野一彦, 村井利昭, 森直, 保田昌秀, 山本芳彦

丸善株式会社, Feb, 2004 (ISBN: 4621073125)

Presentations

177

2-メトキシ-4-フェネチルオキシ-3-トリフルオロアセチルキノリンとヒドラジン類との位置選択的求核置換反応を利用した含フッ素ピラゾロキノリン類の簡便合成

小西満, 中尾理香, 脇野華香, 岡田悦治

日本化学会第100春季年会, Mar, 2020
新規含フッ素チアジノベンズインダゾール類の簡便合成

中尾理香, 小西満, 太田規央, 岡田悦治

日本化学会第100春季年会, Mar, 2020
7-ジメチルアノ-8,10-ビス(トリフルオロアセチル)ナフト[1,2-d][1,3]オキサジン誘導体とヒドラジン類との芳香族求核置換反応を利用した含フッ素オキサジノベンズインダゾール類の合成

中尾理香, 小西満, 岡田悦治

日本化学会第100春季年会, Mar, 2020
新規含フッ素チアジノベンズアクリジン類の簡便合成

小西満, 岡田悦治

日本化学会第100春季年会, Mar, 2020
2,4-ビス(トリフルオロアセチル)-1-ナフチルアミン類とアミン類との芳香族求核置換反応に関する計算化学的検討

小西満, 太田規央, 神鳥安啓, 岡田悦治

日本化学会第100春季年会, Mar, 2020
Computational Study for the Selective Aromatic Nucleophilic Substitution on 4-Dimethylamino-2-methoxy-3-trifluoroacetylquinoline

Y. Harada, S. Sasakawa, N. Ota, Y. Kamitori, E. Okada

27th International Society of Heterocyclic Chemistry Congress, Sep, 2019
新規7-ジメチルアミノ-4-トリフルオロメチル-2,4-ジヒドロ-1H-ナフト[1,2-d][1,3]オキサジン類の簡便合成

高山恭平, 太田規央, OKADA ETSUJI

日本化学会第99春季年会, Mar, 2019
ローソン試薬を用いる含フッ素ナフト[1,2-d][1,3]オキサジンからナフト[1,2-d][1,3]チアジンへの環変換反応

高山恭平, OKADA ETSUJI

日本化学会第99春季年会, Mar, 2019
7-ジメチルアミノ-8,10-ビス(トリフルオロアセチル)ナフト[1,2-d][1,3]チアジン誘導体の合成とアミン類との芳香族求核置換反応

住谷尚紀, 高山恭平, OKADA ETSUJI

日本化学会第99春季年会, Mar, 2019
4-ジメチルアミノ-2-メトキシ-3-トリフルオロアセチルキノリンとチオール類との選択的芳香族求核置換反応に関する計算化学的検討

原田祐輔, 太田規央, 神鳥安拝, OKADA ETSUJI

日本化学会第99春季年会, Mar, 2019
2,4-ジプロピルチオ-3-トリフルオロアセチルキノリン類とアミン類との位置選択的求核置換反応

原田祐輔, OKADA ETSUJI

日本化学会第99春季年会, Mar, 2019
1-ジアルキルアミノ-2-トリフルオロアセチルナフタレン類とローソン試薬との反応による新規含フッ素ナフトチアジン類の合成

高山恭平, OKADA ETSUJI

日本化学会第99春季年会, Mar, 2019
新規含フッ素キノリノアクリジン類の簡便合成

原田祐輔, 高山恭平, 山本一貴, OKADA ETSUJI

第48回複素環化学討論会, Sep, 2018
新規含トリフルオロメチルナフトオキサジン類の簡便合成

高山恭平, OKADA ETSUJI

第48回複素環化学討論会, Sep, 2018
新規トリフルオロアセチル化キノリノール誘導体の簡便合成

天野晶雄, OKADA ETSUJI

第48回複素環化学討論会, Sep, 2018
2,4-ジアルコキシ-3-トリフルオロアセチルキノリン類とアミン類との位置選択的求核置換反応

住谷尚紀, 天野晶雄, 木村響, OKADA ETSUJI

第48回複素環化学討論会, Sep, 2018
新規含フッ素キノリノアクリジン類の簡便合成

INOUE NARUAKI, YAMAMOTO KAZUTAKA, OKADA ETSUJI

日本化学会第98春季年会, Mar, 2018
新規トリフルオロアセチル化キノリノール誘導体の簡便合成

AMANO AKIO, OKADA ETSUJI

日本化学会第98春季年会, Mar, 2018
高度に官能基化された含フッ素3,4-ジヒドロ-2H-ピラン類の合成とチオール類との反応

MINAMOTO YUMA, AMANO AKIO, OKADA ETSUJI

日本化学会第98春季年会, Mar, 2018
9-ジメチルアミノ-8-トリフルオロアセチルオキサジノベンズアクリジン類とアニリン類との反応－新規含フッ素オキサジノナフトベンゾフェナントロリン前駆体の合成

NAKATA TOMOHIRO, INOUE NARUAKI, ADACHI TAISHI, OKADA ETSUJI

日本化学会第98春季年会, Mar, 2018

More

Teaching Experience

19

Professional Memberships

1

日本化学会

Research Projects

2

Development of Novel Aromatic Nucleophilic Substitutions and Its Applicafion to the Highly Efficient Synthesis of Biologically Active Fluorine-Containing Heterocycles

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

OKADA Etsuji
Development of New and Highly Efficient Synthetic Methods for Bioactive Fluorine-Containing Heterocyclic Compounds Utilizing Characteristics of Fluorine Atom

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1995 - 1996

OKADA Etsuji

Industrial Property Rights

1

特許4929500 新規ベンゾジアゼピン類

OKADA ETSUJI, 友田健久