2018年12月
CD11c-specific bio-nanocapsule enhances vaccine immunogenicity by targeting immune cells
Journal of Nanobiotechnology
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- 巻
- 16
- 号
- 1
- 開始ページ
- 59
- 終了ページ
- 59
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s12951-018-0386-6
- 出版者・発行元
- Springer Science and Business Media LLC
BACKGROUND: Various nanocarriers have been used to deliver subunit vaccines specifically to dendritic cells (DCs) for the improvement of immunogenicity. However, due to their insufficient DC priming ability, these vaccines could not elicit effective innate immunity. We have recently developed a DC-targeting bio-nanocapsule (BNC) by displaying anti-CD11c IgGs via protein A-derived IgG Fc-binding Z domain on the hepatitis B virus envelope L protein particles (α-DC-ZZ-BNC). RESULTS: After the chemical modification with antigens (Ags), the α-DC-ZZ-BNC-Ag complex could deliver Ags to DCs efficiently, leading to effective DC maturation and efficient endosomal escape of Ags, followed by Ag-specific T cell responses and IgG productions. Moreover, the α-DC-ZZ-BNC modified with Japanese encephalitis virus (JEV) envelope-derived D3 Ags could confer protection against 50-fold lethal dose of JEV injection on mice. CONCLUSION: The α-DC-ZZ-BNC-Ag platform was shown to induce humoral and cellular immunities effectively without any adjuvant.
- リンク情報
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- DOI
- https://doi.org/10.1186/s12951-018-0386-6
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/30077180
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076409
- URL
- http://link.springer.com/content/pdf/10.1186/s12951-018-0386-6.pdf
- URL
- http://link.springer.com/article/10.1186/s12951-018-0386-6/fulltext.html
- ID情報
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- DOI : 10.1186/s12951-018-0386-6
- eISSN : 1477-3155
- PubMed ID : 30077180
- PubMed Central 記事ID : PMC6076409