J-GLOBAL         Last updated: Nov 9, 2018 at 18:07
Showa University
School of Medicine, Second Department of Pharmacology
Ph.D.(Showa University)

Research Areas



Takahito Hirai, Yuki Nishimura, Norimitsu Kurata, Hokuto Namba, Mariko Iwase, Yurika Gomi, Hiromichi Tsuchiya, Tomoyuki Yamakawa, Yuji Kiuchi
In Vivo   32 33-40   Jan 2018
Background/Aim: Benifuuki tea has recently been used as an alternative therapy for pollinosis, and it may be consumed with pharmaceutical drugs. This study aimed to examine cytochrome P450 (CYP)-mediated food-drug interactions with Benifuuki tea i...
Mariko Iwase, Yuki Nishimura, Norimitsu Kurata, Hokuto Namba, Takahito Hirai, Yuji Kiuchi
Biological and Pharmaceutical Bulletin   40 1654-1660   Jan 2017
© 2017 The Pharmaceutical Society of Japan. OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports concerning their drug interactions are insuffic...
Hokuto Namba, Yuki Nishimura, Norimitsu Kurata, Mariko Iwase, Takahito Hirai, Yuji Kiuchi
Biological and Pharmaceutical Bulletin   40 1361-1365   Jan 2017
© 2017 The Pharmaceutical Society of Japan. There have been few reports concerning to the drug-drug interactions (DDIs) with OTC drugs although an increase in the use of OTC drugs in recent years. This current study was conducted to clarify the DD...
Momoko Kawakami, Momoko Kawakami, Sachiko Takenoshita-Nakaya, Sachiko Takenoshita-Nakaya, Yuko Takeba, Yuki Nishimura, Masayuki Oda, Minoru Watanabe, Yuki Ohta, Shinjiro Kobayashi, Takehito Ohtsubo, Shinichi Kobayashi, Naoki Uchida, Naoki Uchida, Naoki Matsumoto
Biological and Pharmaceutical Bulletin   40 1344-1351   Jan 2017
© 2017 The Pharmaceutical Society of Japan. CYP2D6 plays an important role in the metabolism of many drugs such as opioids and antidepressants. Polymorphisms of the CYP2D6 gene are widely observed in the Japanese population, and can affect the fir...
Keisuke Kondo, Takehiko Sambe, Naoki Uchida, Mariko Iwase, Yuki Nishimura, Atsuhumi Manabe, Kakei Ryu, Shinichi Kobayashi, Yoko Inada, Miyuki Ikeda
Journal of the Showa Medical Association   75 665-674   Dec 2015
Dental anesthesia with the intravenous (IV) administration of midazolam (MDZ) has been widely used because of the ease of administration and long-standing clinical experience. However, no detailed reports have investigated the optimal dose necessa...

Research Grants & Projects

Study on Drug Metabolism
polymorphic drug metabolism