2004年9月
Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis infection in mice
MICROBIAL PATHOGENESIS
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- 巻
- 37
- 号
- 3
- 開始ページ
- 119
- 終了ページ
- 124
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.micpath.2004.06.004
- 出版者・発行元
- ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Helicobacter pylori colonizes the gastric mucosa of human and causes chronic gastritis. The previous studies have demonstrated that gamma interferon (IFN-gamma) but not tumor necrosis factor-alpha (TNF-alpha) plays a critical role in pathogenesis of gastritis induced by H. pylori infection. In this study we investigated the induction of gastritis induced by H. felis infection in TNF-alpha-deficient mice, comparing with IFN-gamma-deficient mice. The scores of gastritis and epithelial changes of TNF-alpha-deficient mice and IFN-gamma-deficient mice were significantly lower than that of C57BL/6 mice. Moreover, the degrees of gastritis and epithelial changes of TNF-alpha-deficient mice were rather low compared with that of IFN-gamma-deficient mice. In spleen cell cultures stimulated with heat-killed H.fielis, IFN-gamma production by TNF-alpha-deficient mice and TNF-alpha production by IFN-gamma-deficient mice were significantly reduced compared with those in C57BL/6 mice. These results suggested that TNF-alpha is involved in pathogenesis of gastritis induced by H.fielis infection as IFN-gamma and that an interaction between TNF-alpha and IFN-gamma might be required in pathogenesis of gastritis induced by Helicobacter infection. (C) 2004 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.micpath.2004.06.004
- ISSN : 0882-4010
- Web of Science ID : WOS:000224084600002