大久保正 (Tadashi Ohkubo) - マイポータル - researchmap

基本情報

所属: 旧所属弘前大学医学部附属病院助教授

学位: 薬学修士
薬学博士

J-GLOBAL ID: 200901003466913240
researchmap会員ID: 1000190235

研究キーワード

6

研究分野

3

MISC

30

Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin

M Tanaka, T Ohkubo, K Otani, A Suzuki, S Kaneko, K Sugawara, Y Ryokawa, T Ishizaki

CLINICAL PHARMACOLOGY & THERAPEUTICS 69(3) 108-113 2001年3月
Therapeutic spectrum of nemonapride and its relationship with plasma concentrations of the drug and prolactin

T Kondo, K Mihara, N Yasui, U Nagashima, S Ono, S Kaneko, T Ohkubo, T Osanai, K Sugawara, K Otani

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 20(4) 404-409 2000年8月
Monitoring of carbamazepine and carbamazepine 10,11-epoxide in breast milk and plasma by high-performance Liquid chromatography

R Shimoyama, T Ohkubo, K Sugawara

ANNALS OF CLINICAL BIOCHEMISTRY 37 210-215 2000年3月
Efeects of grapefruit juice on the stereoslective disposition of nicardipine in human : An evidence for dominant presystemic elimination at the gut site.

Eur. J. Clin. Pharmacol. 56 643-649 2000年
Asymmetric redox reactions in human liver stereoselective oxidation of optically active dihydrohaloperidols, dihydrobromoperidols and stereospecific reduction of haloperidol and bromoperidol

M Takeshita, M Miura, T Ohkubo, K Sugawara

ENANTIOMER 5(2) 189-195 2000年
Characteristics of interaction between barbiturate derivatives and various solvents on liquid chromatography and determination of phenobarbital in Japanese human breast milk.

J. Liq. Chromatogr. Rel. Technol. 23(4) 587-599 2000年
Monitoring of zonisamide in human breast milk and metanal plasma by solid-phase extraction HPLC method.

Biomed Chromatogr 13(5) 370-372 1999年
Determination of risperidone and 9-hydroxyrisperidone in human plasma by high-performance liquid chromatography : Application to therapeutic drug monitoring in Japanese patients with schizophrenia.

J Pharm Biomed Anal 19(3/4) 595-601 1999年
Determination of sparfloxacin in plasma by direct injection high performance liquid chromatography with column switching.

J Liq Chromatogr Rel Technol 22(3) 441-449 1999年
Effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolam

N Yasui, T Kondo, K Otani, H Furukori, S Kaneko, T Ohkubo, T Nagasaki, K Sugawara

PSYCHOPHARMACOLOGY 139(3) 269-273 1998年10月
High-performance liquid chromatographic determination of nemonapride and desmethylnemonapride in human plasma using an electrochemical detection

J Chromatogr B 714(2) 293-298 1998年
Correlation between steady-state plasma concentration of mianserin and trazodone in depressed patients.

Eur J Clin Pharmacol 53(5) 347-349 1998年
Determination of Alprazolam and α-Hydroxyalprazolam in Plasma by High-Performance Liquid Chromatography

Takako Nagasaki, Tadashi Ohkubo, Kazunobu Sugawara, Norio Yasui, Koichi Otani, Sunao Kaneko

Analytical Sciences 13(2) 245-249 1997年
Effects of genetically determined s-methenytoin 4-hydroxylation status and cigarett somoking on the single-dose pharmacokinetics of oral alprazolam.

Neuropsychopharm. 16(1) 8-14 1997年
Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test

M Tanaka, K Kato, K Sudo, H Hakusui, T Ohkubo, K Sugawara, S Kaneko, K Otani, K Chiba, T Ishizaki

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS 676(1) 87-94 1996年2月
Column switching high-performance liquid chromatography of ofloxacin in human saliva and correlation between saliva and serum level

Ther. Drug Monit. 18(5) 598-603 1996年
A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans : In vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.

Clin. Pharmacol. Ther. 59(5) 514-519 1996年
INHIBITION OF TRAZODONE METABOLISM BY THIORIDAZINE IN HUMANS

N YASUI, K OTANI, S KANEKO, T OHKUBO, T OSANAI, M ISHIDA, K MIHARA, T KONDO, K SUGAWARA, Y FUKUSHIMA

THERAPEUTIC DRUG MONITORING 17(4) 333-335 1995年8月
Trazodone treatment increases plasma prolactin concentrations in depressed patients

International Clinical Psychopharmacology 10(1) 115-117 1995年
Effects of various factors on steady state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazime

International Clinical Psychopharmacology 10(2) 143-146 1995年

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所属学協会

6

共同研究・競争的資金等の研究課題

6