論文

国際誌
2020年11月3日

Predictive biomarkers for the progression of ocular complications in chronic Stevens-Johnson syndrome and toxic Eeidermal necrolysis.

Scientific reports
  • Yamato Yoshikawa
  • ,
  • Mayumi Ueta
  • ,
  • Hiromi Nishigaki
  • ,
  • Shigeru Kinoshita
  • ,
  • Tsunehiko Ikeda
  • ,
  • Chie Sotozono

10
1
開始ページ
18922
終了ページ
18922
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-020-76064-8

This study aimed to clarify predictive biomarkers of mild and severe ocular complications of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) by examining the cytokines in tears. In 121 chronic-phase SJS/TEN eyes, cytokines in tear samples collected using Schirmer test strips were measured, and ocular sequelae severity was evaluated using an Ocular Surface Grading Score (OSGS) involving 7 components (conjunctivalization, neovascularization, opacification, keratinization, symblepharon, and upper/lower conjunctival-sac shortening), with findings categorized into grades 0-3 (maximum total OSGS: 21). Changes in cytokines between the mild and severe groups (mild: total OSGS of 10 or less, severe: total OSGS of 11 or more), and changes between SJS/TEN cases with and without each of the 7 components, were compared. In the severe group, there was significant upregulation of interleukin (IL)-8 (P < 0.01) and Granzyme B (GrzB) (P < 0.05). IL-8 was significantly upregulated in eyes with conjunctivalization, neovascularization, or opacification, GrzB was upregulated in eyes with keratinization, interferon-γ-inducible protein 10 (IP-10) was downregulated in eyes with conjunctivalization or neovascularization, and IL-1α was upregulated in eyes with opacification (all: P < 0.05). IL-8 and IP-10 was involved in conjunctivalization and neovascularization, while GrzB was involved in keratinization. IL-8 and GrzB in tears may reflect SJS/TEN-related ocular sequelae severity.

リンク情報
DOI
https://doi.org/10.1038/s41598-020-76064-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33144639
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609677
ID情報
  • DOI : 10.1038/s41598-020-76064-8
  • PubMed ID : 33144639
  • PubMed Central 記事ID : PMC7609677

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