MISC

1993年9月

ACTIVIN-A - SERUM LEVELS AND IMMUNOHISTOCHEMICAL BRAIN LOCALIZATION IN RATS GIVEN DIETS DEFICIENT IN L-LYSINE OR PROTEIN

PHYSIOLOGY & BEHAVIOR
  • K TORII
  • ,
  • K HANAI
  • ,
  • K OOSAWA
  • ,
  • M FUNABA
  • ,
  • A OKIYAMA
  • ,
  • M MORI
  • ,
  • T MURATA
  • ,
  • M TAKAHASHI

54
3
開始ページ
459
終了ページ
466
記述言語
英語
掲載種別
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

When a L-lysine (Lys)-deficient diet is given to rats, Lys in plasma and brain declines and rats will then select a Lys solution from among other L-amino acids (AAs). The recording of single-unit activity in the lateral hypothalamic area of these rats suggested that neural plasticity occurred, specifically responding to the deficient nutrient, Lys, centrally and during ingestion of AA. Possible neurotrophic factors in serum from rats with or without deficiency of either protein or Lys was assayed by Hydra japonica. An increase in serum inhibin and activin A was observed in rats fed a Lys-sufficient and nonprotein diet, respectively. However, serum activin A-like activity was severely suppressed under Lys deficiency. Additionally, the immunohistochemical distribution of activin A in the brain was found in the nucleus tractus solitarius, the area postrema, and the arcuate nucleus. These facts indicate that ingestion of Lys-deficient or nonprotein diet caused a change in serum levels of activin A as a possible neurotrophic factor. This release may elicit plasticity in the sensitivity of neurons to deficient AA in the nuclei that could selectively drive ingestive behavior for its particular AA (e.g., Lys) to maintain AA homeostasis.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LT51300008&DestApp=WOS_CPL
ID情報
  • ISSN : 0031-9384
  • Web of Science ID : WOS:A1993LT51300008

エクスポート
BibTeX RIS