小原一男 (Kazuo Obara) - マイポータル - researchmap

基本情報

所属: 静岡県立大学薬学部薬学科薬理学教室講師

J-GLOBAL ID: 200901038398497835
researchmap会員ID: 1000192150

研究キーワード

4

研究分野

3

委員歴

3

MISC

76

Kazuo Obara, Ayako Mitate, Kayo Nozawa, Makiko Watanabe, Yoshihiko Ito and Koichi Nakayama: Interactive role of protein phosphatase 2A and protein kinase Cα in the stretch-induced triphosphorylation of myosin light chain in canine cerebral artery

Kazuo Obara, Ayako Mitate, Kayo Nozawa, Makiko Watanabe, Yoshihiko Ito, Koichi Nakayama

J. Vasc. Res. 47(2) 115-127 2010年
Interactive Role of Protein Phosphatase 2A and Protein Kinase C alpha in the Stretch-Induced Triphosphorylation of Myosin Light Chain in Canine Cerebral Artery

Kazuo Obara, Ayako Mitate, Kayo Nozawa, Makiko Watanabe, Yoshihiko Ito, Koichi Nakayama

JOURNAL OF VASCULAR RESEARCH 47(2) 115-127 2010年
The relaxant effect of okadaic acid on canine basilar artery involves activation of PKCα and phosphorylation of the myosin light chain at Thr-9

Kazuo Obara, Yoshihiko Ito, Hiroki Shimada, Koichi Nakayama

Eur. J. Pharmacol. 598(1-3) 87-93 2008年11月
The relaxant effect of okadaic acid on canine basilar artery involves activation of PKC alpha and phosphorylation of the myosin light chain at Thr-9

Kazuo Obara, Yoshihiko Ito, Hiroki Shimada, Koichi Nakayama

EUROPEAN JOURNAL OF PHARMACOLOGY 598(1-3) 87-93 2008年11月
プロテインキナーゼCによるミオシン軽鎖リン酸化の制御

小原一男

血管医学 9 239-245 2008年
Stretch-induced triphosphorylation of myosin light chain and myogenic tone in canine basilar artery

K Obara, M Uchino, M Koide, A Yamanaka, K Nakayama

EUROPEAN JOURNAL OF PHARMACOLOGY 534(1-3) 141-151 2006年3月
Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice

Y Ito, K Obara, R Ikeda, M Ishii, Y Tanabe, T Ishikawa, K Nakayama

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 451(6) 803-813 2006年3月
脳血管平滑筋のメカノトランスダクションーミオシン軽鎖の多重リン酸化とERK活性化—

中山貢一, 小原一男

血管 29 57-65 2006年
Involvement of novel protein kinase C isoforms in carbachol-stimulated insulin secretion from rat pancreatic islets

T Ishikawa, E Iwasaki, K Kanatani, F Sugino, Y Kaneko, K Obara, K Nakayama

LIFE SCIENCES 77(4) 462-469 2005年6月
Ionic mechanism for contractile response to hyposmotic challenge in canine basilar arteries

S Yano, T Ishikawa, H Tsuda, K Obara, K Nakayama

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 288(3) C702-C709 2005年3月
Interactive role of protein kinase C-ｴ with Rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.

J. Vasc. Res. 42: 67-76 2005年
Interactive role of protein kinase C-delta with Rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model

K Obara, S Nishizawa, M Koide, K Nozawa, A Mitate, T Ishikawa, K Nakayama

JOURNAL OF VASCULAR RESEARCH 42(1) 67-76 2005年
Differential interplay between protein kinase C and Rho-kinase in the endothelin-1-induced and pressure-induced contractions of rat posterior cerebral artery.

J. Cardiovasc. Pharmacol. 44: S265-S267 2004年
クモ膜下出血後の脳血管攣縮発生のメカニズム-細胞内signal transductionと血管平滑筋の形質転換-

脳卒中 26: 538-543 2004年
Differential interplay between protein kinase C and Rho-kinase in the endothelin-1-induced and pressure-induced contractions of rat posterior cerebral artery.

J. Cardiovasc. Pharmacol. 44: S265-S267 2004年
Evidence for protein kinase C-mediated activation of Rho-kinase in a porcine model of coronary artery spasm

T Kandabashi, H Shimokawa, K Miyata, Kunihiro, I, Y Eto, K Morishige, Y Matsumoto, K Obara, K Nakayama, S Takahashi …

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 23(12) 2209-2214 2003年12月
Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain

S Nishizawa, K Obara, M Koide, K Nakayama, S Ohta, T Yokoyama

JOURNAL OF VASCULAR RESEARCH 40(2) 169-178 2003年3月
血管収縮の分子機構

冠疾患誌 9: 77-81 2003年
Interactive role of tyrosine kinase, protein kinase C, and Rho/Rho kinase systems in the mechanotransduction of vascular smooth muscles

K Nakayama, K Obara, Y Tanabe, M Saito, T Ishikawa, S Nishizawa

BIORHEOLOGY 40(1-3) 307-314 2003年
20-Hydroxyeicosatetraenoic acid potentiates stetch-indused contraction of canine basilar artery via PKCα-mediated inhibition of K_Ca channel

British journal of Phaemacology 137(8) 1362-1370 2002年12月

もっとみる

書籍等出版物

12

Mechanosensitivity in Cells and Tissues. Mechanosensitivity of the Heart

Springer 2009年
Mechanosensitivity in Cells and Tissues. Mechanosensitivity of the Heart

Springer 2009年
Interactive role of protein kinase C isoforms and Rho kinase in vasospasm after experimental subarachnoid hemorrhage.

Cerebral Vasospasm- Advances in Research and Treatment- 2004年
Protein kinase C isoforms, Rho kinase, and Myosin light chain phosphorylation as mechanisms of cerebral vasospasm after subarachnoid hemorrhage.

Cerebral Vasospasm-Advances in Research and Treatment- 2004年
Interactive role of protein kinase C isoforms and Rho kinase in vasospasm after experimental subarachnoid hemorrhage.

Cerebral Vasospasm- Advances in Research and Treatment- 2004年
Protein kinase C isoforms, Rho kinase, and Myosin light chain phosphorylation as mechanisms of cerebral vasospasm after subarachnoid hemorrhage.

Cerebral Vasospasm-Advances in Research and Treatment- 2004年
20-Hydroxyeicosa- tetraenoic acid potentiated contractile activation of canine basilar artery in response to stretch via protein kinase Ca-mediated inhibition of calcium-activated potassium channel.

Molecular and Cellular Aspects of Muscle Contraction 2003年
20-Hydroxyeicosa- tetraenoic acid potentiated contractile activation of canine basilar artery in response to stretch via protein kinase Ca-mediated inhibition of calcium-activated potassium channel.

Molecular and Cellular Aspects of Muscle Contraction 2003年
カリクリンAはモルモット結腸紐平滑筋細胞の電位依存性外向き電流を調節する

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle 1992年
モルモット結腸紐平滑筋細胞におけるカルシウムおよびカリウムチャネルのタンパク質のリン酸化による調節について

Excitation-contraction coupling in skeletal, cardiac, and smooth Muscle 1992年
Calyculin A Modulates Voltage-Dependent Outward Current in Guinea-pig Taenia Coli Smooth Muscle Cells

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle 1992年
Calcium and Potassium Channel Regulation by Protein Phosphorylation in Smooth Muscle Cells of Guinea Pig Taenia Coli

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle 1992年

所属学協会

6

共同研究・競争的資金等の研究課題

8

骨格筋における機械的刺激誘発性糖取込み機構の解明

2000年
Study on Mechanical Stimulation-induced Glucose Uptake in Skeletal Muscle

2000年
血管平滑筋の伸展誘発性収縮に関する研究

1994年
Study on Stretch-Induced Contraction of Vascular Smooth Muscles

1994年
線維芽細胞の収性性に関する研究

1992年
Study on Contractility of fibroblast

1992年
平滑筋収縮調節機構に関する研究

1977年
Study on Modulation of Smooth Muscle Contraction

1977年