Papers

Peer-reviewed
2 2012

Therapeutic Effect of Frequent Injections of GnRH Analogue in a Beagle with Knobbed Acrosome Abnormality of Sperm

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Eiichi Kawakami
  • ,
  • Tomoko Yagi
  • ,
  • Masanori Kobayashi
  • ,
  • Tatsuya Hori

Volume
74
Number
2
First page
201
Last page
204
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1292/jvms.11-0272
Publisher
JAPAN SOC VET SCI

A Beagle dog (3 years old) that ejaculated high percentages (mean +/- SE: 29.1 +/- 1.2%) of sperm with a knobbed acrosome abnormality and a low number of sperm and that also had a low plasma testosterone (T) level was given 10 subcutaneous injections of 1 mu g of gonadotropin-releasing hormone analogue (GnRH-A) at 3-day intervals. The plasma T level and number of sperm increased 12-14 weeks after the first injection. Although the percentages of sperm with knobbed acrosome abnormality did not change after the GnRH-A therapy, the number of sperm and percentage of actively motile sperm increased after the therapy, and a bitch gave birth to 5 healthy puppies after intravaginal artificial insemination with fresh semen collected 14 weeks after the first injection.

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Link information
DOI
https://doi.org/10.1292/jvms.11-0272
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21914975
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000301885500010&DestApp=WOS_CPL