Papers

Peer-reviewed
10 2014

Efficacy of Low-Dose Human Chorionic Gonadotropin Therapy in Dogs with Spermatogenic Dysfunction: A Preliminary Study

REPRODUCTION IN DOMESTIC ANIMALS
  • M. Kobayashi
  • ,
  • T. Hori
  • ,
  • E. Kawakami

Volume
49
Number
5
First page
E44
Last page
E47
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1111/rda.12366
Publisher
WILEY-BLACKWELL

Contents Human chorionic gonadotropin (hCG) is a glycoprotein used in the treatment of spermatogenic dysfunction. However, previous studies performed in dogs show that repeated administration of large doses of hCG produces antibodies against hCG. In this study, we examined the efficacy of low-dose injections of hCG in four male dogs with spermatogenic dysfunction and low plasma testosterone (T) levels. We administered 100IU hCG per animal, five times at 3-day intervals, and evaluated the changes in semen quality and plasma T levels. The total number of sperm in ejaculate, the percentage of progressively motile sperm and the plasma T levels had increased by 3-5weeks after the first injection of hCG in three of the four dogs, but were unchanged in the fourth dog. These findings indicate that temporary improvement of the semen quality of dogs with spermatogenic dysfunction and low plasma T levels is possible after five low-dose injections of hCG.

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Link information
DOI
https://doi.org/10.1111/rda.12366
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25130649
Scopus
https://www.scopus.com/record/display.uri?eid=2-s2.0-84908607383&origin=inward
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342132400001&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84908607383&origin=inward