論文

査読有り
2001年4月

High Plasma Estradiol-17β Levels in Dogs with Benign Prostatic Hyperplasia and Azoospermia

Journal of Veterinary Medical Science
  • Eiichi Kawakami
  • ,
  • Eri Amemiya
  • ,
  • Kenji Namikawa
  • ,
  • Chikako Kashiwagi
  • ,
  • Tatsuya Hori
  • ,
  • Toshihiko Tsutsui

63
4
開始ページ
407
終了ページ
412
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1292/jvms.63.407

The semen quality of 22 dogs (4 to 7 years old) with benign prostatic hyperplasia (BPH) was examined at the hospital of our university, and 4 of the 22 BPH dogs were diagnosed as azoospermic. The mean peripheral plasma estradiol-17β (E2) level (17.3 pg/ ml) of the 18 BPH dogs with spermatogenic function was higher than that of 5 normal male dogs and their mean T level (1.7 ng/ml) was lower. The mean E2 level (27.3 pg/ml) of the 4 BPH dogs with azoospermia was significantly higher than the value in the BPH dogs with spermatogenic function (P<0.01), and the mean T level (1.1 ng/ml) was significantly lower (P<0.05). Five normal male dogs were given 10 intramuscular injections of estradiol benzoate (E2B) 5 μg/kg, at 3-day intervals to investigate the relationship between high plasma E2 levels and the cause of the BPH and azoospermia. Their testes and prostates were measured and biopsied both before and 30 days after the start of E2B injections. At 30 days after the start of the E2B injections, the mean peripheral plasma T levels had decreased by half, and the mean testicular volume had decreased to 88% of original volume. The numbers of spermatocytes, spermatids, and spermatozoa in the seminiferous tubules of all of the dogs were significantly lower (P<0.05, 0.01). In addition, the mean prostatic volume increased to 130%, the mean height of the glandular epithelium decreased, and the glandular lumen became increased in diameter. These findings indicate that both BPH and serious spermatogenic dysfunction may be simultaneously induced by protracted high plasma E2 levels in dogs.

リンク情報
DOI
https://doi.org/10.1292/jvms.63.407
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11346175
Scopus
https://www.scopus.com/record/display.uri?eid=2-s2.0-0035316115&origin=inward
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035316115&origin=inward