2017年4月
MicroRNA expression profiling in canine prostate cancer
JOURNAL OF VETERINARY MEDICAL SCIENCE
- 巻
- 79
- 号
- 4
- 開始ページ
- 719
- 終了ページ
- 725
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1292/jvms.16-0279
- 出版者・発行元
- JAPAN SOC VET SCI
Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.
- リンク情報
-
- DOI
- https://doi.org/10.1292/jvms.16-0279
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28239051
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402193
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406225100005&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1292/jvms.16-0279
- ISSN : 0916-7250
- eISSN : 1347-7439
- PubMed ID : 28239051
- PubMed Central 記事ID : PMC5402193
- Web of Science ID : WOS:000406225100005