Papers

Peer-reviewed
4 2017

MicroRNA expression profiling in canine prostate cancer

JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Masanori Kobayashi
  • ,
  • Akiko Saito
  • ,
  • Yoshikazu Tanaka
  • ,
  • Masaki Michishita
  • ,
  • Masato Kobayashi
  • ,
  • Mami Irimajiri
  • ,
  • Takeharu Kaneda
  • ,
  • Kazuhiko Ochiai
  • ,
  • Makoto Bonkobara
  • ,
  • Kimimasa Takahashi
  • ,
  • Tatsuya Hori
  • ,
  • Eiichi Kawakami

Volume
79
Number
4
First page
719
Last page
725
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1292/jvms.16-0279
Publisher
JAPAN SOC VET SCI

Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.

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Link information
DOI
https://doi.org/10.1292/jvms.16-0279
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28239051
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000406225100005&DestApp=WOS_CPL