論文

査読有り
1999年7月

MDM2 and MDMX bind and stabilize the p53-related protein p73

CURRENT BIOLOGY
  • WM Ongkeko
  • ,
  • XQ Wang
  • ,
  • WY Siu
  • ,
  • AWS Lau
  • ,
  • K Yamashita
  • ,
  • AL Harris
  • ,
  • LS Cox
  • ,
  • RYC Poon

9
15
開始ページ
829
終了ページ
832
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0960-9822(99)80367-4
出版者・発行元
CURRENT BIOLOGY LTD

The p53 gene encodes one of the most important tumor suppressors in human cells and undergoes frequent mutational inactivation in cancers. MDM2, a transcriptional target of p53, binds p53 and can both inhibit p53-mediated transcription [1,2] and target p53 for proteasome-mediated proteolysis [3,4], A close relative of p53, p73, has recently been identified [5,6]. Here, we report that, like p53, p73 alpha and the alternative transcription product p73 beta also bind MDM2, Interaction between MDM2 and p53 represents a key step in the regulation of p53, as MDM2 promotes the degradation of p53. In striking contrast to p53, the half-life of p73 was found to be increased by binding to MDM2, Like MDM2, the MDM2-related protein MDMX also bound p73 and stabilized the level of p73, Moreover, the growth suppression functions of p73 and the induction of endogenous p21, a major mediator of the p53-dependent growth arrest pathway, were enhanced in the presence of MDM2, These differences between the regulation of p53 and p73 by MDM2/MDMX may highlight a physiological difference in their action.

リンク情報
DOI
https://doi.org/10.1016/S0960-9822(99)80367-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10469568
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000081850800024&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0960-9822(99)80367-4
  • ISSN : 0960-9822
  • PubMed ID : 10469568
  • Web of Science ID : WOS:000081850800024

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