1999年7月
MDM2 and MDMX bind and stabilize the p53-related protein p73
CURRENT BIOLOGY
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- 巻
- 9
- 号
- 15
- 開始ページ
- 829
- 終了ページ
- 832
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0960-9822(99)80367-4
- 出版者・発行元
- CURRENT BIOLOGY LTD
The p53 gene encodes one of the most important tumor suppressors in human cells and undergoes frequent mutational inactivation in cancers. MDM2, a transcriptional target of p53, binds p53 and can both inhibit p53-mediated transcription [1,2] and target p53 for proteasome-mediated proteolysis [3,4], A close relative of p53, p73, has recently been identified [5,6]. Here, we report that, like p53, p73 alpha and the alternative transcription product p73 beta also bind MDM2, Interaction between MDM2 and p53 represents a key step in the regulation of p53, as MDM2 promotes the degradation of p53. In striking contrast to p53, the half-life of p73 was found to be increased by binding to MDM2, Like MDM2, the MDM2-related protein MDMX also bound p73 and stabilized the level of p73, Moreover, the growth suppression functions of p73 and the induction of endogenous p21, a major mediator of the p53-dependent growth arrest pathway, were enhanced in the presence of MDM2, These differences between the regulation of p53 and p73 by MDM2/MDMX may highlight a physiological difference in their action.
- リンク情報
- ID情報
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- DOI : 10.1016/S0960-9822(99)80367-4
- ISSN : 0960-9822
- PubMed ID : 10469568
- Web of Science ID : WOS:000081850800024